ISSN:
0951-4198
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Physics
Notes:
Negative-ion fast-atom bombardment mass spectra of free and conjugated bile acids are dominated by [M — H]- pseudomolecularions. Collision-induced dissociations of these pseudomolecular ions give charge-remote fragmentation patterns which are useful for structural identification. Taurine (2-aminoethanesulrtionic acid)-conjugated bile acids have a high cross-section for charge-remote fragmentation, and give the most informative and intense spectra among the naturally occurring bile acids. In the present study, collision-induced dissociation spectra of bile acids derivatized with different aliphatic and aromatic aminosulphonates, and with 2-amlnoethyl hydrogen sulphate have been compared. All show charge-remote fragmentation patterns. Determination of the intensities of the fragment ions shows that the highest sensitivity is usually obtained with aromatic aininosulpho-nate derivatives.
Additional Material:
9 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/rcm.1290070314
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