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  • 1
    Electronic Resource
    Electronic Resource
    Multiple detector triple coincidence spectrometer for (e,3e) electron impact double-ionization measurements (1995)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 66 (1995), S. 3137-3143 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: An (e,3e) spectrometer for the study of double ionization of magnesium by electron impact is described. With the spectrometer the angular and energy distributions of the ejected electrons can be measured over a range of incident-electron energies. The spectrometer incorporates two ejected-electron electrostatic energy analyzers and a tandem electrostatic analyzer for the scattered electrons. Up to eight detectors can be placed at the focal planes of each of the ejected analyzers. This increases the data rate by a factor of 64 over arrangements with two ejected-electron detectors. In order to reduce noise and establish the energy of the final state of the doubly charged residual magnesium ion, triple-coincidence electronics are used with a preprocessing circuit to reduce dead time. The first double-ionization study with the instrument was the ejection of a 2p inner valence electron by a 3.5 keV incident electron accompanied by the subsequent filling of the 2p hole and the emission of a 35 eV Auger electron. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1145542
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  • 2
    Electronic Resource
    Electronic Resource
    Synthesis and Characterization of Novel Thermally Stable Polypyrazoles (1995)
    s.l. : American Chemical Society
    Macromolecules 28 (1995), S. 444-453 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00106a007
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  • 3
    Electronic Resource
    Electronic Resource
    Synthesis of New Aromatic Polyenaminonitriles with Improved Processability and Thermal Stability (1995)
    s.l. : American Chemical Society
    Macromolecules 28 (1995), S. 854-859 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00108a008
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  • 4
    Electronic Resource
    Electronic Resource
    9,10-Bis{2-[4-(N,N-diphenylamino)phenyl]ethynyl}anthracene (1997)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 53 (1997), S. 241-243 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270196012620
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  • 5
    Electronic Resource
    Electronic Resource
    DNA repair by recycling reverse transcripts (1997)
    [s.l.] : Nature Publishing Group
    Nature 386 (1997), S. 32-32 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Haber and Moore reply-We do not yet know how a specific segment of Tyl can be captured at the sites of double-strand breaks, and the suggestion by Lauermann provides one plausible explanation of the source of the putative cDNA segment. But we feel that the details of the events that we ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/386032a0
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  • 6
    Electronic Resource
    Electronic Resource
    Development of an alternative light source to lasers for photodynamic therapy: 2. Comparative in vivo tumour response characteristics (1995)
    Springer
    Lasers in medical science 10 (1995), S. 121-126 
    Details
    ISSN: 1435-604X
    Keywords: Photodynamic therapy ; Haematoporphyrin derivative ; In vivo ; Laser ; Light source ; Murine tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract The performance of a low cost, table-top/portable light source was tested against an argon ion pumped dye laser for in vivo photodynamic therapy (PDT). The prototype delivers up to 1 W via a 4 mm flexible lightguide within a 30 nm bandwidth centred at any wavelength from 300 nm to 1200 nm at fluence rates of up to 8 W cm−2. An in situ bioassay using regrowth delay of tumour T50/80 was used to quantify the relative efficacy of the prototype with a laser. The tumours were sensitized with haematoporphyrin derivative (HpD) and externally irradiated. There was no significant difference in the response of the tumour to treatment between the two light sources (p = 0.69). Mean growth delays ranged from 2 days (light dose 10 J cm−2) to 20 days (light dose 100 J cm−2). The estimate for the difference in means (laser minus prototype growth delay) was only 0.66 days and was not statistically significant. This in vivo study demonstrates that the prototype is equivalent to a laser in PDT effect. The device has low capital/running cost, is simple to use and is one of the most powerful, spectrally efficient non-laser PDT sources available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02150849
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  • 7
    Electronic Resource
    Electronic Resource
    Acute and Chronic Toxicity of Azinphos-Methyl to Two Estuarine Species, Mysidopsis bahia and Cyprinodon variegatus (1997)
    Springer
    Archives of environmental contamination and toxicology 32 (1997), S. 436-441 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract. The acute and chronic toxicity of azinphos-methyl (Guthion) was evaluated for two estuarine species in the laboratory. Mysids (Mysidopsis bahia) and sheepshead minnows (Cyprinodon variegatus) were selected as the representative invertebrate and vertebrate estuarine test species, respectively. The toxicological endpoints determined for each species included the 96-h LC50, the no-observed-effect concentration (NOEC), the maximum acceptable toxicant concentration (MATC), and the acute-to-chronic ratio. The 96-h LC50 value derived for sheepshead minnows (2.0 μg/L) was seven times higher than the 96-h LC50 value (0.29 μg/L) derived for mysids. The MATCs were 0.024 μg/L and 0.24 μg/L for the mysid and the sheepshead minnow, respectively. The estimated acute-to-chronic ratios were 12 for mysids and 8.3 for sheepshead minnows.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002449900210
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  • 8
    Electronic Resource
    Electronic Resource
    Demonstration of peripheral fucose units in N-linked glycans of human immunodeficiency virus type 1 gp 120: effects on glycoprotein conformation (1997)
    Springer
    Archives of virology 142 (1997), S. 2465-2481 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary.  Fucosylated N-linked glycans are important constituents of membrane glycoproteins, owing to their significance as biologically active ligands for several selectins and their role in modulating protein conformation of viral glycoproteins. The human immunodeficiency virus type 1 (HIV-1) glycoprotein contains more than 30 different glycan structures but so far fucose was found associated solely with the innermost GlcNAc of N-linked glycans. In the present report we determined whether fucose units also were linked to the distal GlcNAc via α(1–3) or α(1–4) linkages in N-linked glycans of gp 120. [3H]-fucose labelled gp 120 was subjected to endoglycosidase F digestion, releasing diantennary complex type N-linked glycans, but leaving the inner polypeptide-bound carbohydrates, GlcNAc and possibly associated fucose units, intact. Gel filtration of the digested material revealed that [3H]-fucose label was released from gp 120 by this treatment, indicating presence of peripheral fucose units. Furthermore, [3H]-focuse label was also released by treatment of the labelled gp 120 with an α-L-fucosidase specifically removing fucose in α(1–3) and α(1–4) linkages. Altogether the results indicated presence of fucose units linked to peripheral GlcNAc of gp 120 N-linked glycans. We have earlier shown that other peripheral carbohydrate determinants, i.e. β(1–4)-galactose on N-linked glycans, maintain a correct antigenic conformation of gp 120. Using a coupled ELISA system, where changes in antigenic behaviour of a viral glycoprotein were correlated to stepwise elimination of peripheral monosaccharides from N-linked glycans, we found that treatment of gp 120 with a pan-specific α-fucosidase as well as an enzyme specific for α(1–3)- or α(1–4)-linked fucose disclosed a hidden linear epitope situated in the gp 120 C2 region. The effects of the general fucosidase on epitope exposure was more prominent than those obtained with the enzyme with narrow specificity, suggesting that peripheral and inner fucose units co-operate in the maintenance of gp 120 conformation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007050050255
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  • 9
    Electronic Resource
    Electronic Resource
    First trimester of pregnancy laparoscopic procedures (1997)
    Springer
    Surgical endoscopy and other interventional techniques 11 (1997), S. 1216-1217 
    Details
    ISSN: 1432-2218
    Keywords: Key words: Laparoscopy — Pregnancy — Appendectomy — Cholecystectomy — Twins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Laparoscopic procedures are being performed during pregnancy with increasing frequency; however, few first-trimester operations have been published. Two first-trimester procedures are here reported, both performed with uneventful recoveries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004649900573
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  • 10
    Electronic Resource
    Electronic Resource
    Colonic Sulfide in Pathogenesis and Treatment of Ulcerative Colitis (1997)
    Springer
    Digestive diseases and sciences 42 (1997), S. 1571-1579 
    Details
    ISSN: 1573-2568
    Keywords: HYDROGEN SULFIDE ; BUTYRATE OXIDATION ; AMINO SALICYLIC ACID ; ULCERATIVE COLITIS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A role for colonic sulfide in the pathogenesisand treatment of ulcerative colitis (UC) has emergedbased on biochemical, microbiological, nutritional,toxicological, epidemiological, and therapeuticevidence. Metabolism of isolated colonic epithelial cellshas indicated that the bacterial short-chain fatty acidn-butyrate maintains the epithelial barrier and thatsulfides can inhibit oxidation of n-butyrate analogous to that observed in active UC. Sulfurfor fermentation in the colon is essential forn-butyrate formation and sulfidogenesis aids disposal ofcolonic hydrogen produced by bacteria. The numbers of sulfate-reducing bacteria and sulfidogenesisis greater in UC than control cases. Sulfide is mainlydetoxified by methylation in colonic epithelial cellsand circulating red blood cells. The enzyme activity of sulfide methylation is higher in red bloodcells of UC patients than control cases. Patients withUC ingest more protein and thereby sulfur amino acidsthan control subjects. Removing foods rich in sulfur amino acids (milk, eggs, cheese) has proventherapeutic benefits in UC. 5-Amino salicylic acidreduces fermentative production of hydrogen sulfide bycolonic bacteria, and aminoglycosides, which inhibit sulfate-reducing bacteria, are of therapeuticbenefit in active UC. Methyl-donating agents are acategory of drugs of potential therapeutic use in UC. Acorrelation between sulfide production and mucosal immune responses in UC needs to be undertaken.Control of sulfidogenesis and sulfide detoxification maybe important in the disease process of UC, althoughwhether their roles is in an initiating or promoting capacity has yet to be determined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018851723920
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