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  • 1
    Electronic Resource
    Electronic Resource
    Five new experimental stations at the SRS Daresbury from a 6 T superconducting wiggler magnet : Proceedings of the 5th international conference on synchrotron radiation instrumentation (1995)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 66 (1995), S. 1633-1635 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Daresbury Laboratory is currently completing the construction and commissioning of five new experimental research stations utilizing high flux hard x-ray radiation from a 6 T superconducting wiggler magnet. The broad areas of science covered by the new stations and the novel features are presented. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1145867
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  • 2
    Electronic Resource
    Electronic Resource
    Synthesis, Structure and Properties of Five-Coordinate Copper(II) Complexes of Pentadentate Ligands with Pyridyl Pendant Arms (1995)
    s.l. : American Chemical Society
    Inorganic chemistry 34 (1995), S. 254-261 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00105a041
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  • 3
    Electronic Resource
    Electronic Resource
    Barbados Low Dose Aspirin Study in Pregnancy (BLASP): a randomised trial for the prevention of pre-eclampsia and its complications (1998)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 105 (1998), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To determine whether prophylactic, low dose controlled-release aspirin improves outcome for pregnant women and their babies in Barbados.Design Randomised placebo-controlled trial.Setting The Queen Elizabeth Hospital, Barbados.Population All women attending antenatal clinics between 12 and 32 weeks of gestation were eligible, if without specific contraindications to aspirin and unlikely to deliver immediately.Methods Randomisation was computer-generated in the antenatal clinic; 1822 women were allocated to receive 75 mg controlled-release aspirin and 1825 matching placebo.Main outcome measures Proteinuric pre-eclampsia, other pregnancy-induced hypertension, pregnancy duration, birthweight, stillbirths and neonatal deaths, major neonatal events.Results All but three women from each group were followed up successfully. Forty-four percent were primigravid, and 8% had previous obstetric complications. There were no significant differences between the allocated treatment groups in the incidence of proteinuric pre-eclampsia (40 [2.2%] of those allocated aspirin, compared with 46 [2.5%] allocated placebo), of preterm delivery (255 [14.0%] vs 270 [14.8%]), of birthweight 〈 1500 g (32 [1.7%] vs 33 [1.8%]) or of stillbirth and neonatal death (44 [2.4%] vs 38 [2.1%]). Aspirin was not associated with excess risk of maternal orfetal bleeding.Conclusions The results of this study in Barbados do not support the routine use of low dose aspirin for prevention of pre-eclampsia or its complications, confirming results of previous large trials in other settings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1998.tb10088.x
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  • 4
    Electronic Resource
    Electronic Resource
    Synthetic chemical diversity: solid phase synthesis of libraries of C2 symmetric inhibitors of HIV protease containing diamino diol and diamino alcohol cores (1995)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 38 (1995), S. 2995-3002 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00016a001
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  • 5
    Electronic Resource
    Electronic Resource
    ELECTROPHYSIOLOGICAL PROPERTIES OF THE RAT MIDDLE CEREBRAL ARTERY AT DIFFERENT LEVELS OF PASSIVE WALL TENSION (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 22 (1995), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Simultaneous measurements of intracellular membrane potential and myogenic tone of proximal segments of the rat middle cerebral artery, mounted in a small vessel myograph, were made at two levels of passive wall tension.2. At low levels of passive tension (less than 0.25mN/mm) vessels had a resting membrane potential of approximately -65mV. Addition of KCl (5–60 mmol/L), BaCl2 (0.01–3 mmol/L) or tetraethylammonium (TEA; 0.1–3 mmol/L) resulted in a concentration-dependent depolarization, to approximately—40 mV, generally associated with a contractile response. After the application of high levels of passive tension (to approximately 2mN/mm maximum) the resting membrane potential of the smooth muscle cells was—40 to—45 mV. This more positive membrane potential was generally associated with an increase in myogenic tone of the vessel. Under these conditions, addition of 5–20 mmol/L KCl resulted in a strong hyperpolarization of the cell along with a concomitant decrease in myogenic tone of the artery. The hyperpolarization and vasorelaxation induced by KCl (5–20 mmol/L) were blocked by BaCl2 (0.5–1 mmol/L).3. While the addition of ryanodine (10 μmol/L) to vessels under low tension had no effect, when added to a vessel under high tension, this agent caused a rhythmic oscillation in membrane potential. This oscillation was augmented by BaCl2 (1mmol/L) and inhibited by nifedipine (10nmol/L) and 4-aminopyridine (1 mmol/L).4. This study suggests that the electrophysiological and mechanical properties of the isolated rat middle cerebral artery depend on the passive resting conditions under which the vessel is studied. The depolarization of membrane potential observed with increased passive tension appears to result from the closure of an inward rectifying K+ channel. These results indicate that the inward rectifying K+ channel plays an important role in regulating vascular reactivity due to its functional dependence on the mechanical status of the blood vessel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1995.tb01926.x
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  • 6
    Electronic Resource
    Electronic Resource
    KATP CHANNEL BLOCKING ACTIONS OF QUATERNARY IONS PLAY NO ROLE IN THEIR ANTIPROLIFERATIVE ACTION ON MOUSE LEUKAEMIA AND RAT VASCULAR SMOOTH MUSCLE CELLS IN VITRO (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 25 (1998), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The aim of the present study was to investigate the possibility that, in the two cell lines examined, alterations in cell growth caused by lipophilic quaternary ions may involve KATP channels. We examined the effect of tetraphenylphosphonium (TPP), tetraphenylboron (TPB), rhodamine 123, dequalinium chloride (DECA) and the non-quaternary ion cisplatin on the proliferation of L1210 mouse leukaemia cells and rat smooth muscle cells in vitro. The KATP channel opener levcromakalim (LKM) and the Katp channel antagonist glibenclamide were also tested.2. From growth-inhibition studies, the rank order of potency (based on pIC50 values) using L1210 leukaemia cells was: DECA (6.61) 〉 cisplatin (6.09) = rhodamine 123 (6.01) 〉 TPP (5.61) 〉 TPB (4.25). Levcromakalim and glibenclamide were found to be inactive at the maximum concentrations used (100 μmol/L). A different rank order of potency was obtained in rat aortic smooth muscle cells: cisplatin (6.33) 〉 DECA (5.67) 〉 TPP (4.96) 〉 rhodamine 123 (4.1). Tetraphenylboron (30μmol/L), LKM (100 μmol/L) and glibenclamide (100 μmol/L) were found to be inactive.3. When the negatively charged TPB (30 μmol/L) was combined with some of the active agents, the potency of the active agents was increased. Thus, in L1210 cells, rhodamine 123, DECA and TPP were all more potent at inhibiting cell growth in the presence of TPB. Tetraphenylboron had no effect on cisplatin in this cell line. In rat smooth muscle cells, TPB (30 μ mol/L) potentiated the effect of rhodamine 123 but had no effect on the actions of cisplatin, DECA or TPP.4. In functional studies, rhodamine 123 was a weak antagonist of the vasorelaxant responses to the KATP channel opener LKM in the porcine right circumflex artery in vitro. The pKB value obtained for rhodamine 123 at 100 μmol/L was 4.95. Dequalinium chloride was inactive.5. We found no correlation between the actions of the compounds tested to antagonize KATP channels and their ability to inhibit cell proliferation. In addition, compounds known to regulate KATP channel activity failed to influence proliferative rates. These results suggest that KATP channels are not involved in the antiproliferative action of TPP and other quaternary ions in the two cell lines studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1998.tb02172.x
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  • 7
    Electronic Resource
    Electronic Resource
    Spatial organization of olfactory receptor neurons on the antenna of the cabbage looper moth (1998)
    Springer
    Journal of comparative physiology 183 (1998), S. 433-442 
    Details
    ISSN: 1432-1351
    Keywords: Key words Electrophysiology ; Noctuidae ; Pheromone ; Single-cell ; Sensilla trichodea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Electrophysiological responses to stimulation with behaviorally relevant compounds were recorded from receptor neurons within specialized classes of sensilla on the antennae of male cabbage looper moths. Receptor neurons were found that specifically respond to stimulation with Z-7,12:AC, Z-7,14:AC, Z-9,14:AC, and Z-7,12:OH. Specialized receptor neurons were not found for the three remaining pheromone blend components, 12:AC, Z-5,12:AC, or 11,12:AC. However, a new class of sensillum containing a pair of neurons insensitive to all of the cabbage looper pheromone components was encountered. In addition, spatial patterns of distribution along the flagellum for identified classes of sensilla are described. Sensilla containing Z-7,12:AC-sensitive neurons are preferentially located on the proximal half of the antennal flagellum. In addition to this distribution along the length of the antenna, a pattern across individual flagellar subsegments is described. Sensilla containing neurons sensitive to Z-9,14:AC were found exclusively on the lateral margins of individual flagellar subsegments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003590050269
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  • 8
    Electronic Resource
    Electronic Resource
    Electrophysiological responses of receptor neurons in mosquito maxillary palp sensilla to carbon dioxide (1995)
    Springer
    Journal of comparative physiology 177 (1995), S. 389-396 
    Details
    ISSN: 1432-1351
    Keywords: Mosquito ; Electrophysiology ; Host-seeking behavior ; Carbon dioxide ; Sensilla basiconica
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Sensilla basiconica on the maxillary palps of female Aedes aegypti contain a receptor neuron which produces a phasic-tonic pattern of action potential response to low concentrations (150–300 ppm) of carbon dioxide (CO2), a stimulus known to be involved with host seeking behavior. These receptor neurons respond reliably to small increments in CO2 concentration (e.g., 50 ppm). We were particularly interested in evaluating the possibility that the sensitivity to step increases in CO2 concentration could be modulated by alterations in the background levels of CO2, over a range which might be encountered during host-seeking behavior. We report here that the response (impulses/s) to a single pulse of a given concentration of CO2 appears to be independent of the background level of CO2, unless that level is equal to or greater than the concentration of the stimulus pulse. Females of other mosquito species, including: Anopheles stephensi, Culex quinquefasciatus, Culiseta melanura, and Aedes taeniorhynchus, also possess sensilla with receptor neurons that respond with comparable sensitivity to CO2 stimulation. However, there is much interspecific variation in both the external morphology of the maxillary palp and the distribution of sensilla along the palp. Male Ae. aegypti have morphologically similar sensilla which also contain a receptor neuron that responds to CO2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00187475
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  • 9
    Electronic Resource
    Electronic Resource
    Low molecular-weight factor from Plesiastrea versipora (Scleractinia) that modifies release and glycerol metabolism of isolated symbiotic algae (1998)
    Springer
    Marine biology 130 (1998), S. 553-557 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract When symbiotic dinoflagellate algae (Symbiodinium sp., isolated from the coral Plesiastrea versipora) were incubated with NaH14CO3 in the light in seawater, they released 22.69±9.16 nmol carbon/106 algae. Release of photosynthetically fixed carbon was stimulated more than six-fold for algae incubated in host-tissue homogenate (148.54±97.03 nmol C/106 algae) and more than four-fold (102.00±49.16 nmol C/106 algae) for algae incubated in a low molecular weight fraction (≤1 000 M r ) prepared from host homogenate. Soluble released 14C-labelled products, as determined by chromatography and autoradiography, were the same when algae were incubated in either host homogenate or the low molecular weight fraction. After 4 h incubation in the light (300 mol photons m−2 s−1),␣intracellular␣glycerol increased in algae incubated with the low molecular weight fraction (an increase of 0.39 to␣0.67 nmol glycerol/106 algae) compared with little or no increase in algae incubated in seawater (0 to 0.12 nmol glycerol/106 algae). Partial inhibition of triglyceride synthesis (up to 51%) was also observed when algae were incubated in the low molecular weight fraction. All these effects are the same as those observed when algae were incubated in host homogenate. These data indicate that the “host release-factor” activity of P.␣versipora is a compound of low molecular weight.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002270050276
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  • 10
    Electronic Resource
    Electronic Resource
    The Effect of Orography on Evaporation (1998)
    Springer
    Boundary layer meteorology 86 (1998), S. 487-504 
    Details
    ISSN: 1573-1472
    Keywords: Orography ; Planetary boundary layer ; Atmospheric feedback ; Surface resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The effect of orography on the spatial variability of surface evaporation is studied numerically for two hill heights and two prescribed forms of surface resistance. A numerical model of the planetary boundary layer carrying scalars of temperature and specific humidity, and with a surface energy balance scheme, is employed. It is found that the difference in mean evaporation between model runs with hills and analogous runs for flat terrain may be explained primarily by an increase in surface area and adiabatic cooling at the hill surface.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1000795206459
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