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  • 1995-1999  (4)
  • 1999  (1)
  • 1995  (3)
Material
Years
  • 1995-1999  (4)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 132 (1995), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Pachydermoperiostosis is a rare osteo-cutaneous disease characterized by hypertrophy of bones and surrounding soft tissues. The cutaneous manifestations include coarsening of facial features, cutisverticis gyrata, digital clubbing, hyperhidrosis and scborrhoea.The pathogenetic mechanism of the disease is still debated, and proposed aetiological factors include genetic influences, anomalies in fibroblast activity, or alteration in peripheral blood flow.We studied a patient with the incomplete form of Pachydermoperiostosis. assessing epidermal growth factor receptor (EGF-R) and sex hormone steroid receptors (SR) in the affected skin, and also evaluating the urinary excretion of EGF.The results showed high levels of nuclear steroid receptors, increased cytosolic oestrogen receptors, and no detectable progesterone and androgen cytosolic receptors. EGF-R was also undetectable, and the urinary excretion of EGF was elevated. These findings suggest that the increased tissue sensitivity to circulating sex-steroids could induce enhanced tissue EGF/transforming growth factor α (TGF-α) production and utilization. The SR-EGF-R system could therefore be involved in determining hypertrophy of the affected tissues.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Homologous recombination targeting vectors in which the BDNF (Fig. la) and NT4 coding regions (Fig. \b) were disrupted and partially deleted were used to generate mice with these mutations at their endogenous BDNF and NT4 loci, respectively (Fig. \c,d). In agreement ...
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The CD4/CD8 ratio has long been used for the follow-up and monitor of many infectious diseases. Following the demonstration in 1983 that the CD4/CD8 ratio in the mouse is under genetic control, it was subsequently shown to be controlled by a major locus in man. To define the mode of inheritance of the CD4/CD8 ratio, we addressed the absolute number of CD4 and CD8 cells in a large unselected control sample and in members of 70 nuclear families. Pedigrees of nuclear families were analyzed by complex segregation analysis. Data was adjusted prior to this analysis to remove the effects of relevant covariates. The non-genetic-transmission and the multifactorial model could be easily rejected for both CD4 and CD8 cells. Among the different inheritance models, involving both a major gene and a multifactorial (MFT) component, a major autosomal recessive gene with a residual MFT effect controlling the high number of CD4 and a major autosomal recessive gene with a residual MFT effect controlling the high number of CD8 cells were the significantly best-fitting ones. Our findings have some practical implications. Among all, the knowledge of the CD4+ cell number and the proportion between CD4+ and CD8+ T cells could be a useful parameter in predicting human immunodeficiency virus infection outcome.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Plasma chemistry and plasma processing 16 (1995), S. S99 
    ISSN: 1572-8986
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Notes: Abstract D.C. plasma jets temperature and velocity distributions as well as the arc root fluctuations at the anode were studied for Ar-H2 (25 vol%) plasma forming gases. The parameters were the arc current up to 700 A, the total gas flow rate up to 100 slm, and the nozzle diameter which was varied from 6 to 10 mm. The trajectories of partially stabilized zirconia particles into the jet were studied by a 2D laser imaging technique and two fast (100 ns) two color pyrometers. The results have revealed the difficulty to inject small particles into the plasma flow since most were found to by-pass the jet rather than penetrate it. The results also show the broad trajectory distribution within the jet and the influence of the arc root fluctuations on the mean particle trajectory distribution within the jet. Beside the measurements of the particle surface temperature and velocity distributions in flight, the particle flattening and the cooling of the resulting splats were studied statistically for single particles all over the spray cone. Such studies have emphasized the drastic influence of the substrates or previously deposited layers temperature on the contact between them and the splats. At 200–300°C this contact is excellent (cooling rates of the order of 100 K/μs for 1 μm thick splats) and it results in a columnar growth within the splats and the layered splats of a bead (up to 500 layered splats). This growth can be observed through passes provided the bead surface temperature has not cooled too much (a few tens of K) before the next bead covers it. A/C values up to 60 MPa were achieved with PSZ coatings. The effect of impact velocity of the particles, of substrate preheating temperature, of relative movments torch to substrate, of substrate oxidation on A/C values and splat formation were also studied.
    Type of Medium: Electronic Resource
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