ISSN:
1440-1681
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
1. Endothelium-dependent relaxation by a-adrenoceptor agonists was examined in the thoracic aorta from normoten-sive Wistar-Kyoto (WKY) rats and stroke-prone spontaneously hypertensive rats (SHRSP).2. In ring preparations from both strains, noradrenaline-induced contraction was increased by L-nitro arginine (L-NNA), a NO synthesis inhibitor.3. L-NNA increased the contraction induced by phenyl-ephrine, an α1-adrenoceptor agonist. UK-14304 and clonidine, α2-adrenoceptor agonists, did not contract the preparations with intact endothelium. However, these agents contracted preparations when NO synthesis was inhibited.4. In a precontracted preparation, clonidine and UK-14304 induced relaxations. The relaxations in SHRSP aorta were smaller than those in WKY aorta.5. These results indicate that a-agonists release NO from endothelium in WKY and SHRSP aorta. The mechanism related to NO release by α2-adrenoceptor agonist is impaired in SHRSP aorta.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1440-1681.1995.tb02856.x
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