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  • 1995-1999  (8)
  • 1960-1964
  • 1935-1939
  • 1998  (4)
  • 1996  (4)
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  • 1995-1999  (8)
  • 1960-1964
  • 1935-1939
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  • 1
    Electronic Resource
    Electronic Resource
    Fetal pathology in intrauterine death due to parvovirus B19 infection (1996)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 103 (1996), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To study the pathological features of fetuses dying because of parvovirus B19 infection, with particular reference to the presence of hydrops; to assess the usefulness of immunochemistry as a screening method for the detection of parvovirus infection at post-mortem examination.Design Review of clinical, sonographic, serological and pathological data; immunohistochemical staining of post-mortem tissue.Sample Cases of intrauterine fetal death occurring during the 18-month period January 1993 to June 1994 inclusive, referred for post-mortem examination to the Pathology Department, Royal Victoria Infirmary, Newcastle upon Tyne.Results Eleven cases of fetal death due to parvovirus infection were identified. Seven fetuses were less than 18-week size. Three fetuses showed conspicuous hydropic change. One of the 11 cases was detected for the first time by retrospective immunochemical screening. Of cases originating from the Newcastle district, parvovirus infection was responsible for about 10YO of all non-malformed fetal deaths occurring between 10 and 24 weeks of gestation referred for pathological examination.Conclusions During the period of study, parvovirus infection was a relatively common cause of mid-trimester fetal death. Many fetuses dying because of this infection are not noticeably hydropic, and the possibility of parvovirus infection should be considered in any case of intrauterine fetal death. Immunochemistry can be used to confirm the histopathological diagnosis, and may be of particular help where there is advanced autolysis; immunohistochemical screening may detect occasional cases not initially identified by examination of routinely stained tissue sections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1996.tb09664.x
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  • 2
    Electronic Resource
    Electronic Resource
    Development of the third generation electron cyclotron resonance ion source : Proceedings of the 7th international conference on ion sources (1998)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 682-684 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The LBNL third generation electron cyclotron resonance (ECR) ion source has progressed from a concept to the fabrication of a full scale prototype superconducting magnet structure. This new ECR ion source will combine the recent ECR ion source techniques that significantly enhance the production of high charge state ions. The design includes a plasma chamber made from aluminum to provide additional cold electrons, three separate microwave feeds to allow multiple-frequency plasma heating (at 10, 14, and 18 GHz or at 6, 10, and 14 GHz) and very high magnetic mirror fields. The design calls for mirror fields of 4 T at injection and 3 T at extraction and for a radial field strength at the wall of 2.4 T. The prototype superconducting magnet structure which consists of three solenoid coils and six race track coils with iron poles forming the sextupole has been tested in a vertical Dewar. After training, the sextupole magnet reached 105% of its design current with the solenoids off. With the solenoids operating at approximately 70% of their full design field, the sextupole coils operated at 95% of the design value which corresponds to a sextupole field strength at the plasma wall of more than 2.1 T. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1149169
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  • 3
    Electronic Resource
    Electronic Resource
    Numerical simulation of viscous free surface flow (1998)
    Bradford : Emerald
    International journal of numerical methods for heat & fluid flow 8 (1998), S. 445-464 
    Details
    ISSN: 0961-5539
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Methods used to track the free surface in numerical flow simulations, typically during the casting of metals into moulds are examined in this paper. The algorithm employed makes use of a mixed interpolation formulation to approximate the discretised governing equations for elimination on a Langrangian type moving mesh. Significant savings in CPU time are realised by virtue of the the air domain not being considered in the finite element analysis. The advantages and drawbacks of commonly used methods are discussed, and a method proposed for the numerical simulation of flow where the free surface boundary conditions are important. The effectiveness of the proposed algorithm in solving typical industrial flow problems is demonstrated using numerical examples. The results obtained are compared with analytical and numerical data with a view to validating the algorithm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09615539810213223
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  • 4
    Electronic Resource
    Electronic Resource
    Book review (1996)
    Springer
    Pediatric nephrology 10 (1996), S. 252-252 
    Details
    ISSN: 1432-198X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00862099
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  • 5
    Electronic Resource
    Electronic Resource
    A case of neonatal Bartter’s syndrome (1996)
    Springer
    Pediatric nephrology 10 (1996), S. 414-418 
    Details
    ISSN: 1432-198X
    Keywords: Key words: Prostaglandins ; Tamm-Horsfall protein ; Bartter’s syndrome ; Captopril
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We describe a child with a neonatal presentation of Bartter’s syndrome. Unlike infants previously described with a similar clinical presentation, the urinary excretion rate of prostaglandin E2 in this child was similar to normal children and Tamm-Horsfall protein was distributed normally in the thick ascending limb of the loop of Henle. The child failed to respond to indomethacin alone, but thrived after the addition of the angiotensin converting enzyme inhibitor, captopril.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050131
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  • 6
    Electronic Resource
    Electronic Resource
    Cathepsin D antigenic epitopes identified by the humoral responses of ovarian cancer patients (1998)
    Springer
    Cancer immunology immunotherapy 46 (1998), S. 48-54 
    Details
    ISSN: 1432-0851
    Keywords: Key words Cathepsin D ; Epitopes ; Autoantigens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Previous studies implicated cathepsin D as one commonly recognized target of tumor-reactive immunoglobulins from ovarian cancer patients. These immunoglobulins are shown to be immunoreactive with both the 52-kDa procathepsin D and the 32-kDa mature cathepsin D derived from the UL-1 ovarian cancer cell line. Whether the carbohydrate domains or the core protein were associated with its immunogenicity was analyzed with cathepsin D isolated from tunicamycin-treated UL-1 cells. No significant difference was detected in the immunoreactivity of patient serum with the glycosylated and deglycosylated forms of the cathepsin D, suggesting that patient humoral responses are directed primarily against the core protein. To define the antigenic epitopes of cathepsin D, tryptic fragments were prepared from UL-1-derived procathepsin D. The epitopes of the core protein recognized by sera from more than one patient were identified using a peptide-specific enzyme-linked immunosorbent assay and microsequencing of positive immunoreactive peptides. This protocol identified four epitopes: two peptides within the pro-peptide, a third at the carboxy terminus and the fourth at the glycosylation site of the mature enzyme. This approach to the identification of specific antigenic epitopes may be useful in defining effective targets for directed active immunotherapy against cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050459
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  • 7
    Electronic Resource
    Electronic Resource
    A molecular genetic map of the long arm of chromosome 6R of rye incorporating the cereal cyst nematode resistance gene, CreR (1998)
    Springer
    Theoretical and applied genetics 97 (1998), S. 1000-1012 
    Details
    ISSN: 1432-2242
    Keywords: Key words CCN ; RFLP ; PCR ; Heterodera avenae ; Genetic mapping
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  A genetic map of the long arm of chromosome 6R of rye was constructed using eight homoeologous group-6 RFLP clones and five PCR markers derived from the rye-specific dispersed repetitive DNA family, R173. The map was developed using a novel test-cross F1 (TC-F1) population segregating for resistance to the cereal cyst nematode. Comparisons were made between the map generated with other rye and wheat group-6 chromosome maps by the inclusion of RFLP clones previously mapped in those species. Co-linearity was observed for common loci. This comparison confirmed a dramatic reduction in recombination for chromosome 6R in the TC-F1 population. The CreR locus was included in the linkage map via progeny testing of informative TC-F1 individuals. CreR mapped 3.7 cM distal from the RFLP locus, XksuF37. Comparative mapping should allow the identification of additional RFLP markers more closely linked to the CreR locus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050984
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  • 8
    Electronic Resource
    Electronic Resource
    Cloning and comparative mapping of a gene from the commonly deleted region of DiGeorge and Velocardiofacial syndromes conserved in C. elegans (1996)
    Springer
    Mammalian genome 7 (1996), S. 639-643 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. We have identified and cloned a gene, ES2, encoding a putative 476 amino acid protein with a predicted M r of 52,568. The gene is localized within the DiGeorge/Velocardiofacial syndrome locus on 22q11.2 and is deleted in all the patients in which a deletion within 22q11 could be demonstrated, with the exception of one patient. ES2 is expressed in all the tissues studied. Sequence comparison showed identity with five ESTs and at the amino acid level the sequence was highly similar to, and collinear with, a hypothetical C. elegans protein of unknown function. Mutation analysis was performed in 16 patients without deletion, but no mutation has been found. The cDNA sequence is conserved in mouse and is localized on MMU16B1-B3, known to contain a syntenic group in common with HSA 22q11.2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003359900197
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