ISSN:
1435-1803
Keywords:
Acidosis
;
calcium
;
hypercontracture
;
reperfusion injury
;
Na+/HCO3 −
;
symporter
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In ischemia the cytosol of cardiomyocytes acidifies; this is reversed upon reperfusion. One of the major pHi-regulating transport systems involved is the Na+/H+ exchanger. Inhibitors of the Na+/H+ exchanger have been found to more effectively protect ischemic-reperfused myocardium when administered before and during ischemia than during reperfusion alone. It has been hypothesized that the protection provided by pre-ischemic administration is due to a reduction in Na+ and secondary Ca2+ influx. Under reperfusion conditions Na+/H+ exchange inhibition also seems protective since it prolongs intracellular acidosis which can prevent hypercontracture. In detail, however, the mechanisms by which Na+/H+ exchange inhibition provides protection in ischemic-reperfused myocardium are still not fully identified.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00788905
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