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  • 1
    Electronic Resource
    Electronic Resource
    High-dose proton pump inhibitor plus amoxycillin for the treatment or retreatment of Helicobacter pylori infection (1996)
    Oxford BSL : Blackwell Science
    Alimentary pharmacology & therapeutics 10 (1996), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: The combination of 120 mg of omeprazole (40 mg t.d.s.) and amoxycillin has been reported to be effective for treating H. pylori infections. Methods: Normal volunteers with H. pylori infection received high-dose omeprazole (40 mg t.d.s.) or lansoprazole (60 mg t.d.s.) plus amoxycillin 750 mg t.d.s. for 14 days. The studies were open label and not randomized as those receiving omeprazole plus amoxycillin had previously failed lower dose omeprazole (20 mg b.d.) plus amoxycillin therapy more than 6 months previously. Those receiving lansoprazole plus amoxycillin had not been previously treated. Four to 6 weeks after ending antimicrobial therapy, H. pylori status was determined by Genta stain of gastric mucosal biopsies. Results: Forty-three volunteers entered the study and 41 completed it. The overall success with high-dose proton pump inhibitor plus amoxycillin was 34.9%. For the individual regimens the per-protocol results were 48% (95% CI=28–69%) with lansoprazole and 12.5% (95% CI=2–38%) with omeprazole. Compliance was 〉95% for both regimens. Side-effects were experienced by four lansoprazole and three omeprazole subjects, and caused two omeprazole subjects to withdraw. Cure rates were similar among different races and ethnic groups, between men and women, and between smokers and non-smokers. The level of the pre-treatment urea breath test also did not predict outcome. Conclusion: High-dose proton pump inhibitor plus amoxycillin combinations for treatment of H. pylori infection yielded unacceptable results, as the 95% confidence intervals did not include an 80% cure rate. These combinations do not yield consistent results worldwide and cannot be recommended as primary therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1996.77248000.x
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  • 2
    Electronic Resource
    Electronic Resource
    Metronidazole, ranitidine and clarithromycin combination for treatment of Helicobacter pylori infection (modified Bazzoli's triple therapy) (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 10 (1996), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Multi-drug regimens are generally required to reliably cure Helicobarter pylori infection. Metronidazole, clarithromycin and omeprazole has proven to be an effective combination therapy with a cure rate of 90% or greater. Methods: We evaluated a 14-day combination regimen for H. pylori infection consisting of metronidazole 500 mg b.d., clarithromycin 250 mg b.d. and ranitidine 300 mg b.d. (MRC) instead of omeprazole. Ranitidine alone was continued for an additional 4 weeks. H. pylori status was determined by rapid urease testing. histopathology using the Genta stain, and by culture at entry and 4 weeks after completing antimicrobial therapy. Results: Twenty-seven patients with documented peptic ulcer disease and H. pylori infection were treated. Five had previously failed macrolide-based antimicrobial therapy: none had received metronidazole. All ulcers were healed at week 6 except one patient taking naproxen; his H. pylori infection was cured. Overall, H. pylori infection was cured in 78% (95% CI = 58–91%). In patients with clarithromycin-sensitive isolates, the cure rate was 20 of 23 (87%, 95% C.I. = 66–97%); only one of four patients (25%) with clarithromycin-resistant isolates was cured. In contrast, four of five patients with metronidazole-resistant isolates were cured (80%). In patients with isolates sensitive to both antibiotics, the cure rate was 16 of 18 (89% 95% C.I. = 65–99%). Mild side effects were reported by 27%, including diarrhoea and altered taste. Compliance averaged 98%. Conclusion: These results suggest that the combination of metronidazole, ranitidine and clarithromycin results in high cure rates in patients with clarithromycin-sensitive isolates. Omeprazole may not be required for Bazzoli's triple therapy; and large multicentre comparative trials are indicated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1996.tb00185.x
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  • 3
    Electronic Resource
    Electronic Resource
    Spatial and temporal population structure of Brevicoryne brassicae (1996)
    Springer
    Entomologia experimentalis et applicata 78 (1996), S. 121-127 
    Details
    ISSN: 1570-7458
    Keywords: Brevicoryne brassicae ; cellulose acetate ; electrophoresis ; allozyme variation ; population structure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Allozymes from individual aphids were used as markers to examine the structure of Brevicoryne brassicae colonies collected from field experiments at Horticulture Research International, Wellesbourne, during the summers of 1991, 1992 and 1993. Eighteen enzyme systems were examined using cellulose acetate electrophoresis, but only 6-phosphogluconate dehydrogenase (6-PGDH) showed polymorphism (three alleles) in the samples. There were significant differences in gene frequencies between populations at some sites within 1 kilometre and between times of sampling, with an increase in the proportion of the most common genotype AA later in the season, possibly due to selection during the summer of the best adapted clones. These changes in gene frequency might produce biased results in trials screening brassica crops against aphids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00187507
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  • 4
    Electronic Resource
    Electronic Resource
    Low aromatic amino acid concentrations in leaf proteins determine resistance to Frankliniella occidentalis in four vegetable crops (1996)
    Springer
    Entomologia experimentalis et applicata 78 (1996), S. 325-333 
    Details
    ISSN: 1570-7458
    Keywords: Western flower thrips ; host plant resistance ; Capsicum annuum ; Cucumis sativus ; Lactuca sativa ; Lycopersicon esculentum ; indirect selection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Analysis of total aromatic amino acid (free and bound) in some cucumber accessions selected previously for resistance to western flower thrips, Frankliniella occidentalis (Pergande) [Thysanoptera: Thripidae], indicated that low concentrations of these essential nutrients, relative to total leaf protein, were correlated with a reduction in damage by the insect. Further analysis of samples of four important horticultural crops (lettuce, tomato, pepper and cucumber) with unknown levels of resistance to thrips showed a significant genotypic variation in the concentrations of total aromatic amino acids relative to the total leaf protein. Accessions from each crop with low or high concentrations of aromatic amino acids in proteins were exposed to thrips larvae. Regression analysis showed a highly significant positive correlation between aromatic amino acid concentration in leaf protein and thrips damage, regardless of crop species. It is concluded that higher concentrations of aromatic amino acids in plant proteins are important for successful thrips development. These results provide plant breeders with a promising tool for indirect selection without using undesirable insect bioassays.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00193452
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    A nearly optimal deterministic parallel Voronoi diagram algorithm (1996)
    Springer
    Algorithmica 16 (1996), S. 569-617 
    Details
    ISSN: 1432-0541
    Keywords: Voronoi diagram ; Parallel algorithm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract We describe ann-processor,O(log(n) log log(n))-time CRCW algorithm to construct the Voronoi diagram for a set ofn point-sites in the plane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01944352
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