ISSN:
1573-1111
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Triacetyl-β-cyclodextrin (TA-β-CyD), a hydrophobic cyclodextrin derivative, that is insoluble in water, was used to form a complex with flufenamic acid (FA). FA-TA-β-CyD complex formation was demonstrated by differential scanning calorimetry and powder X-ray diffractometry. The release rate of FA from the FA-TA-β-CyD complexes in phosphate buffer pH 6.8 was significantly retarded compared to that of FA from the FA and glucose mixture. When the FA-TA-β-CyD complexes were administered directly into the intraduodenal lumen, the plasma concentration of FA remained at a plateau level (10-18 μg/ml) for 6–8 h. An increased mean residence time of FA following FA-TA-β-CyD complexes administration was observed. These results indicate that TA-β-CyD may serve as a hydrophobic carrier in prolonged-release preparations of FA.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01041565
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