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  • 2000-2004
  • 1995-1999  (2)
  • 2004
  • 1998  (2)
  • 1997
  • Key words Thrombospondin-1  (1)
  • Multiprocessor roblem  (1)
  • 1
    ISSN: 1432-2307
    Keywords: Key words Thrombospondin-1 ; p53 ; Colon cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  If activation of the p53 gene is involved in the progression or metastasis of colon cancer, it may affect the angiogenic phenotype in vivo. To verify this hypothesis, we studied the correlation between p53 accumulation and expression of thrombospondin-1 (TSP1) in colon cancer specimens. Levels of TSP1 gene expression were estimated by Northern blotting in 65 colon cancers. Accumulation of p53 and the distribution of TSP1 protein were evaluated immunohistochemically. Various levels of TSP1 gene expression were seen in colon cancers, while p53 accumulation was confirmed in 42 of the 65 colon cancers. The level of TSP1 gene expression demonstrated a significant inverse correlation with p53 accumulation in colon cancer. Colon cancer cells expressed TSP1 protein and p53 accumulation reciprocally in the same nests. These results suggest that alterations in the tumour suppressor gene p53 may inhibit TSP1 expression in colon cancer.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1614-7456
    Keywords: Hybrid genetic algorithms ; Multiprocessor roblem ; Priority list
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract The multiprocessor scheduling problem is one of the classic examples of NP-hard combinatorial optimization problems. Several polynomial time optimization algorithms have been proposed for approximating the multiprocessor scheduling problem. In this paper, we suggest a geneticizedknowledge genetic algorithm (gkGA) as an efficient heuristic approach for solving the multiprocessor scheduling and other combinatorial optimization problems. The basic idea behind the gkGA approach is that knowledge of the heuristics to be used in the GA is also geneticized alongiside the genetic chromosomes. We start by providing four conversion schemes based on heuristics for converting chromosomes into priority lists. Through experimental evaluation, we observe that the performance of our GA based on each of these schemes is instance-dependent. However, if we simultaneously incorporate these schemes into our GA through the gkGA approach, simulation results show that the approach is not problem-dependent, and that the approach outperforms that of the previous GA. We also show the effectiveness of the gkGA approach compared with other conventional schemes through experimental evaluation.
    Type of Medium: Electronic Resource
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