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  • 2000-2004
  • 1995-1999  (5)
  • 1940-1944
  • 1997  (5)
  • 1
    Electronic Resource
    Electronic Resource
    Mapping of the gene encoding the B56β subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1) (1997)
    Springer
    Human genetics 〈Berlin〉 100 (1997), S. 481-485 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The multiple endocrine neoplasia type 1 (MEN1) locus has been previously localised to 11q13 by combined tumour deletion mapping and recombination studies, and a 0.5-Mb region, flanked by PYGM and D11S449, has been defined. In the course of constructing a contig, we have identified the location of the gene encoding the B56β subunit of protein phosphatase 2A (PP2A), which is involved in cell signal transduction pathways and thus represents a candidate gene for MEN1. We have searched for mutations in the PP2A-B56β coding region, together with the 5′ and 3′ untranslated regions in six MEN1 patients. DNA sequence abnormalities were not identified and thus the PP2A-B56β gene is excluded as the candidate gene for MEN1. However, our precise localisation of PP2A-B56β to this region of 11q13 may help in elucidating the basis for other disease genes mapping to this gene-rich region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050538
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  • 2
    Electronic Resource
    Electronic Resource
    Linkage disequilibrium studies in multiple endocrine neoplasia type 1 (MEN1) (1997)
    Springer
    Human genetics 〈Berlin〉 100 (1997), S. 657-665 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by tumours of the parathyroids, pancreas and anterior pituitary. The MEN1 gene has been localised to a 2-Mb region of chromosome 11q13 by meiotic mapping studies in MEN1 families. Such studies may have a limited resolution of approximately 1 cM (i.e. 1 Mb) and we have therefore investigated 96 MEN1 families (40 British, 17 French, 12 Finnish, 7 Swedish, 7 Dutch, 7 North American, 2 Australian, 1 New Zealand, 1 German, 1 Spanish and 1 Danish) for linkage disequilibrium, in order to facilitate a finer mapping resolution. We have utilised five microsatellite DNA sequence polymorphisms from the candidate region and have accurately determined their allele sizes, which ranged from 161 bp to 272 bp. The heterozygosity and number of alleles (given in brackets), respectively, at the loci were: D11S1883 (76%, 11), D11S457 (55%, 5), PYGM (94%, 18), D11S1783 (10%, 4) and D11S449 (87%, 16). Allelic association was assessed by Chi-square 2 ×n contingency tables, by Fisher exact 2 ×n contingency tables and by a likelihood-based approach. The results of haplotype analysis revealed 91 different affected haplotypes in the 96 families, an identical affected haplotype being observed in no more than two families. These results indicate the absence of an ancestral affected haplotype. Significant linkage disequilibrium (P 〈 0.005) could be established amongst the microsatellite loci but not between the loci and MEN1 in either the total population or in any of the geographical sub-populations. The absence of linkage disequilibrium between MEN1 and the polymorphic loci is probably the result of the occurrence of multiple different disease-causing mutations in MEN1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050569
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Septic arthritis due to bacteroides fragilis after pilonidal sinus resection in a patient with rheumatoid arthritis (1997)
    Springer
    Clinical rheumatology 16 (1997), S. 632-634 
    Details
    ISSN: 1434-9949
    Keywords: Bacteroides Fragilis ; Septic Arthritis ; Pilonidal Sinus ; Rheumatoid Arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bacteroides fragilis is a rare cause of septic arthritis. Most patients with B.fragilis septic arthritis have a chronic joint disease, particularly rheumatoid arthritis, and sources of infection are lesions of the gastrointestinal tract and the skin. We report a 69-year-old male, who developed B.fragilis septic arthritis after pilonidal sinus resection. High level of suspicion of development B.fragilis septic arthritis must be present in patients with chronic joint disease in whom gastrointestinal or skin surgery was previously performed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02247808
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  • 4
    Electronic Resource
    Electronic Resource
    Changing trends in frequency and antimicrobial resistance of urinary pathogens in outpatient clinics and a hospital in Southern Israel, 1991–1995 (1997)
    Springer
    European journal of clinical microbiology & infectious diseases 16 (1997), S. 834-838 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to monitor changes in the frequency and antimicrobial resistance of urinary pathogens over several years, urinary cultures received from outpatient clinics and from a hospital during a period of one month each in 1991 and 1995 were analyzed at a clinical microbiology laboratory. In 1991 and 1995, 1366 and 1534 significant monomicrobic cultures respectively were reviewed. The frequency ofEscherichia coli dropped significantly in the outpatient clinics from 70.5% to 61.2% (p〈0.0001). The frequency ofProteus mirabilis, Morganella morganii, Pseudomonas aeruginosa and other gram-negative bacteria also decreased, but the frequency ofKlebsiella spp. andEnterobacter spp. increased from 2.6% to 5.8% (p〈0.0001). In the hospital, the frequency ofEnterobacter spp. (p〈0.04),Escherichia coli andMorganella morganii declined from 1991 to 1995, whereas the frequency ofPseudomonas aeruginosa (p=0.001),Acinetobacter spp. (p〈0.05),Klebsiella spp.,Proteus mirabilis and other gram-negative rods increased considerably. The frequency of gram-positive aerobic bacteria rose markedly in outpatient specimens from 6.1% to 13.5% (p〈0.0001), while a decline from 14.4% to 9.3% was noted in hospital specimens (p〈0.02). A significant rise in the resistance ofEscherichia coli to gentamicin and ciprofloxacin (p〈0.0001) was detected in outpatient isoates. In the hospital, gram-negative urinary pathogens demonstrated increased resistance to ampicillin (p=0.042), cefuroxime (p=0.005), gentamicin (p=0.002) and ciprofloxacin (p〈0.0001) during the study period. The changing etiology of urinary tract infections and the increasing resistance of organisms indicate that periodic monitoring and possibly also modification of empirical therapy are required.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01700414
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Osseointegration in cortical sheep bone of calcium phosphate implants evaluated by PIXE method and histology (1997)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 36 (1997), S. 315-324 
    Details
    ISSN: 0021-9304
    Keywords: PIXE ; osseointegration ; calcium phosphate ceramic ; hystomorphometry ; bone ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Osseointegration of porous calcium phosphate ceramics evolves in several stages once implanted. Histologic analysis has often been used to evaluate the mechanism of integration of this material. Histologic parameters can be completed by physical analysis to obtain a semiquantitative evaluation of the osseointegration process. The histologic observation of hydroxyapatite (HA)-ceramic-containing bone sections was associated with proton-induced X-ray emission (PIXE) analysis and the results obtained by both methods were compared. Porous HA-ceramic cylinders were implanted in cortical bone of sheep femurs for periods ranging from 2 to 36 weeks. Thick sections of the implant containing bone were made at the end of the implantation period. A scanning line with two proton impacts 0.5 mm apart was plotted from the edges of cortical bone across the implanted ceramic and the X-rays produced were determined. Calcium, phosphorus, zinc, strontium, and iron contents were measured. Following PIXE analysis, the sections were surface-stained and observed under a light microscope to define the osseointegration index. Two regions of the curves were identified for each element characterizing either the bone tissue or the ceramic. Zinc and strontium present in the bone tissue but absent from the ceramics appeared after the 8th and the 12th implantation weeks, respectively. Iron present in the implant decreased with time, and calcium and phosphorus contents tended to be the same at the end of the implantation period in both curve regions. Histologic observation showed that immature bone invaded the pores of the outer layer of the ceramic as early as 2 weeks after implantation. Ceramics were totally osseointegrated 20 weeks after implantation. Osseointegration was apparently still evolving as judged by the PIXE method when histologic integration was considered complete. © 1997 John Wiley & Sons, Inc. J Biomed Mater Res, 36, 315-324, 1997
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
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