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  • 1995-1999  (2)
  • 1997  (2)
  • Engineering  (1)
  • Neutrophils  (1)
  • Aerosol
  • 1
    ISSN: 1432-198X
    Keywords: Key words: Haemolytic uraemic syndrome ; Glomerular thrombosis ; Arteriolar thromboses ; Neutrophils
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract.  Autopsy material was examined from British children dying early in the course of haemolytic uraemic syndrome (HUS). These presented after 1983, the period in which verocytotoxin-producing Escherichia coli (VTEC) infection was confirmed as the leading cause of diarrhoea-associated (D+HUS) in the United Kingdom. Of 18 cases referred for this study, 3 were found on review to have no history of a diarrhoeal prodrome (D-HUS). In the D+ patients, the median duration from onset of diarrhoea to death was 8 days (range 4–42 days). VTEC infection was confirmed in 6 cases. All had neutrophilia at presentation (median 21, range 15–49.8 × 109/l). The 15 cases had uniform pathological features, consisting of glomerular thromboses and congested rather than ischaemic glomeruli. Arteriolar thromboses were common at the hilum of glomeruli and were sometimes also seen proximally, including in interlobular arteries. There were cortical infarcts in 5 cases with extensive thrombosis. Cases were demonstrated to have significantly greater numbers of neutrophils expressed per 100 glomeruli than controls, when counted using immunohistological stains to neutrophil elastase and CD15. This study showed uniformity of the renal changes in D+ HUS and gave further evidence of the importance of neutrophils in the pathogenesis of the disease.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 25 (1997), S. 931-952 
    ISSN: 0271-2091
    Keywords: finite element method ; free surface ; updated Lagrangian-Eulerian ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: An updated free surface Lagrangian-Eulerian finite element kinematic description is used to simulate free surface flow problems associated with mould filling. The method proposed results in an accurate determination of the front, making it ideal for problems in which free surface boundary conditions play an important role. Significant saving in CPU time can be obtained over other fixed mesh approaches by virtue of the air domain being ignored. Assuming a laminar regime for the flow field, a mixed interpolation formulation is used to approximate the discretized governing equations for elimination.   Of particular interest is the method implementation to restrict the number of remeshing operations and track the moving free surface within an arbitrary domain, either with or without internal obstacles. The method used to automatically assign boundary conditions to the changing domain is described. A dam break problem is modelled numerically and compared against experimentally derived data in order to validate the model. A further numerical example demonstrates the capabilities of the algorithm developed to model the filling of an industrial casting. © 1997 John Wiley & Sons, Ltd.
    Additional Material: 23 Ill.
    Type of Medium: Electronic Resource
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