ISSN:
1432-0584
Keywords:
Key words Paroxysmal nocturnal
;
Hemoglobinuria
;
Aplastic anemia
;
GPI-deficient cells
;
CD34+ progenitor cells
;
G-CSF
;
Cyclosporin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Four paroxysmal nocturnal hemoglobinuria (PNH) patients with severe thrombocytopenia, hemolytic anemia and neutropenia were treated using a combination of filgrastim (G-CSF) and cyclosporin. In all patients a trilineage response of hematopoiesis was achieved. In addition, the proportion of glycosyl-phosphatidylinositol (GPI)-deficient granulocytes decreased. All patients mobilized CD34+ hematopoietic progenitors into peripheral blood after starting treatment with G-CSF. The majority of early progenitors (CD34+CD38–) after mobilization into peripheral blood was found to be unaffected by the GPI-anchoring defect. No patient developed leukemia while under therapy. We conclude from these data that the combination of G-CSF and cyclosporin represents an efficient option for the treatment of hypoplastic PNH.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002770050289
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