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  • 1995-1999  (2)
  • 1970-1974
  • 1998  (2)
  • Key words Mandible reconstruction  (1)
  • Keywords: Chromogranin  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of plastic surgery 21 (1998), S. 257-259 
    ISSN: 1435-0130
    Keywords: Key words Mandible reconstruction ; Vascularized cranial bone graft
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Historically, mandibular reconstruction has always been a challenging problem. Various methods have been used including alloplasts such as stainless steel and titanium plates, trays filled with bone fragments, vascularized and non-vascularized bone grafts [1, 2]. Most methods have had variable success until the advent of microsurgical techniques. With the high success rate now obtainable utilizing free tissue transfer, mandible reconstruction has become a procedure with a more predictable outcome and most other reconstructive methods have now been abandoned. In spite of this, clinical situations do arise, such as with the case presented, where for one reason or another, microvascular techniques are either not available, not applicable or have failed. A case of mandibular reconstruction using a vascularized full-thickness calvarial bone graft is presented in which the end result was very satisfactory, both aesthetically and functionally.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-1463
    Keywords: Keywords: Chromogranin ; secretoneurin ; Parkinson's disease ; Alzheimer ; multiple sclerosis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. Human cerebrospinal fluid (CSF) contains chromogranin A and B and secretogranin II which represent peptides secreted from neuronal large dense core vesicles. Within these vesicles these precursor peptides are at least partly processed to smaller peptides. We analysed the CSF levels of chromogranins/secretogranin by radioimmunoassay using specific antisera. The degree of their processing was characterized by molecular sieve column chromatography followed by radioimmunoassay. As previously shown secretogranin II is fully processed to smaller peptides including the peptide secretoneurin, whereas processing of chromogranin A was more limited. For chromogranin B we found in this study a high degree of processing comparable to that of secretogranin II. An analysis of CSF from patients with multiple sclerosis, essential tremor, Alzheimer and Parkinson disease, did not reveal any differences in proteolytic processing of chromogranins/secretogranin when compared to control CSF. We conclude that in the four diseases investigated there is no change in the proteolytic processing of the chromogranins/secretogranin within the large dense core vesicles. The absolute levels of chromogranins/secretogranin varied in CSF collected in different hospitals, however their relative ratios were remarkable constant. We suggest to use this ratio as a parameter to standardise CSF levels of other peptides, e.g. neuropeptides. In Parkinson patients the chromogranin A/secretogranin II ratio was significantly increased whereas in Alzheimer patients and those with essential tremor and multiple sclerosis no change of the ratios was observed. Apparently there are only limited changes in the biosynthesis, processing, secretion and CSF clearance of these peptides in pathological conditions.
    Type of Medium: Electronic Resource
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