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  • 1
    Electronic Resource
    Electronic Resource
    Characterization of two class I genes from the H2-M region: evidence for a new subfamily (1998)
    Springer
    Immunogenetics 47 (1998), S. 264-271 
    Details
    ISSN: 1432-1211
    Keywords: Key words  Divergent class Ib gene ; H2-M Region ; M1 Subfamily ; M10 Subfamily ; Distal Mhc
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  We cloned, sequenced, and mapped two divergent major histocompatibility class Ib genes from BALB/c mice. M9 d and M10 d both have the potential to encode full-length class I molecules, but transcripts were not readily detectable. M9 is 86% similar to M1 in its nucleotide sequence and maps next to it on YAC clones. M9 is only 64% similar to M10 and 60% to H2-K k. Probes from M10 define a new subfamily of eight class I genes in C3H mice; five cluster directly distal to H2-T1, and three are located between M9-1-7-8 and M6-4-5 in the H2-M region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050356
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  • 2
    Electronic Resource
    Electronic Resource
    Investigating the dielectric effects of channel pore water on the electrostatic barriers of the permeation ion by the finite difference Poisson-Boltzmann method (1998)
    Springer
    European biophysics journal 27 (1998), S. 105-112 
    Details
    ISSN: 1432-1017
    Keywords: Key words Pore constant ; Electrostatic barrier ; The FDPB method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract In this paper, the finite difference Poisson-Boltzmann (FDPB) method with four dielectric constants is developed to study the effect of dielectric saturation on the electrostatic barriers of the permeation ion. In this method, the inner shape of the channel pore is explicitly represented, and the fact that the dielectric constant inside the channel pore is different from that of bulk water is taken into account. A model channel system which is a right-handed twist bundle with four α-helical segments is provided for this study. From the FDPB calculations, it is found that the difference of the ionic electrostatic solvation energy for wider domains depends strongly on the pore radius in the vicinity of the ion when the pore dielectric constant is changed from 78 to 5. However, the electrostatic solvation energy of the permeation ion can not be significantly affected by the dielectric constant in regions with small pore radii. Our results indicate that the local electrostatic interactions inside the ion channel are of major importance for ion electrostatic solvation energies, and the effect of dielectric saturation on the electrostatic barriers is coupled to the interior channel dimensions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002490050116
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Salmonella septic arthritis in systemic lupus erythematosus and other systemic diseases (1998)
    Springer
    Clinical rheumatology 17 (1998), S. 282-287 
    Details
    ISSN: 1434-9949
    Keywords: Avascular necrosis ; Immunocompromise ; Salmonella infection ; Septic arthritis ; Steroid ; Systemic lupus erythematosus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Salmonella infection is an important problem in immunocompromised patients. The synovium is a particular metastatic focus ofSalmonella infection and can result in many disabilities of life. Systemic lupus erythematosus (SLE) patients were highly susceptible toSalmonella infection. In the past 6 years, 41 patients withSalmonella septic arthritis have been treated in our hospital. Eleven patients had an underlying systemic disease of SLE which presented with a distinctive clinical course. Alcoholic liver disease (six cases) was another common underlying systemic disease. The most frequent predisposing articular factor was avascular necrosis (16 cases). The hip joint was the most commonly involved site.Salmonella group B was the most common serotype (30/41). Seventy-three per cent (8/11) of the SLE group had involvement of two or more joints compared with only three out of 30 patients in the non-SLE group. The sex differentiation shows a predominance of young females (10/11) in the SLE group and middle-aged males in the non-SLE group. Moreover, in the SLE group, all 11 patients shared the risk of lupus nephritis and steroid use. Ten patients hadSalmonella group B bacteraemia and five had urinary tract infections simultaneously. In the non-SLE group, there were 10 patients with a history of steroid use, three with antecedent enteritis, 12 with bacteraemia, and three with necrotising fasciitis. Seven patients in each of the groups had a recurrent course. However, three patients in the non-SLE group had died during the episode of septic arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01451006
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    Paper (German National Licenses)
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