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  • 1
    ISSN: 0006-3525
    Keywords: conformational analysis, of TOAC peptides ; electron spin resonance, of TOAC peptides ; fluorescence quenching, of TOAC peptides ; 310-helical structure, of TOAC peptides ; peptide conformation, TOAC-based ; peptide interactions, TOAC-based ; X-ray diffraction, of TOAC peptides ; Cα-tetrasubstituted α-amino acids, peptides rich in ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid is a nitroxide spin-labeled, achiral Cα-tetrasubstituted α-amino acid that has recently been shown to be an effective β-turn and 310/α-helix inducer in peptides and an excellent and relatively rigid electron spin resonance probe and fluorescence quencher. © 1998 John Wiley & Sons, Inc. Biopoly 47: 153-158, 1998
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    ISSN: 0006-3525
    Keywords: Aib peptides ; crystal state structure ; helical peptides ; peptide helices ; x-ray crystallography ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The crystal-state preferred conformations of six Nα-blocked pentapeptide esters, each containing four helicogenic, achiral α-aminoisobutyric acid (Aib) residues followed by one chiral L-valine (L-Val) or Cα-methyl-L-valine [(αMe)Val] residue at the C-terminus, have been assessed by x-ray diffraction analysis. In all of the compounds the —(Aib)4— sequence is folded in a regular 310-helical conformation. In the four pentapeptides characterized by the L-(αMe)Val residue two conformationally distinct molecules occur in the asymmetric unit. Conversely, only one molecule is observed in the asymmetric unit of two pentapeptides with the C-terminal L-Val residue. In the L-Val based peptides the helical screw sense of the —(Aib)4— sequence is right-handed, whereas in the L—(αMe)Val— analogues both right- and left-handed helical screw senses concomitantly occur in the two crystallographically independent molecules. © 1998 John Wiley & Sons, Inc. Biopoly 46: 433-443, 1998
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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