ISSN:
1573-3904
Keywords:
antibiotics
;
biological activity
;
N-carboxy anhydride
;
penicillin
;
stability
;
Cα-tetrasubstituted α-amino acid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary Reaction of the N-carboxyanhydride from Cα-methyld-phenylglycine with either 6-aminopenicillanic acid or 7-amino-3-desacetoxy-cephalosporanic acid furnishes the corresponding ampicillin and cephalexin analogues. Neither the biological activity nor the chemical stability of these new semi-synthetic antibiotics are superior to those of their unmethylated counterparts.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02443539
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