ISSN:
0942-0940
Keywords:
Keywords: Niravoline; arginine vasopressin inhibitor; tumour-origin brain oedema; C6 glioma.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Niravoline is a selective κ-opioid receptor agonist. Its effect on tumour-origin brain oedema was investigated in a brain tumour model created by implantation of C6 glioma cells into the brains of Wistar rats. Five weeks after the tumour cell implantation, niravoline was administered iv at 1 mg/kg, a total of four times at one-hour intervals. In the control group (i.e., saline or vehicle-treated rats), this brain tumour model was found to result in a statistically significant increase in the water content in selected brain regions except for the frontal region, the tumour-containing region and the region surrounding the tumour-containing region. Administration of niravoline inhibited the increase in the water content in the brain regions remote from the tumour.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s007010050374
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