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  • 1
    Electronic Resource
    Electronic Resource
    The effect of hydrophobic and hydrophilic channel walls on the structure and diffusion of water and ions (1999)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 111 (1999), S. 7985-7999 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Molecular dynamics simulations are carried out to determine the effects of channel wall structure on water and ion properties. We compare hydrophobic (Lennard-Jones 5-3 and atomic) and molecular-hydrophilic cylindrical pores of 2–6 Å in effective radius, relevant to the study of most significant biological ion channels including gramicidin A, ACh, and potassium channels, and to the study of many microporous materials. Large variations in levels of self-diffusion and rotational correlation within hydrophobic channels are explained in terms of water geometry, hydrogen bonding, and dipole correlation. The differing levels of water structure and self-diffusion in hydrophobic and hydrophilic pores arise because of marked differences in the preferred orientation of water dipole moments, and due to hydrogen bonding with molecules on the pore lining. Axial sodium ion diffusion does not experience large variations with pore size, despite anomalous stability in moderate-sized hydrophobic pores. We attribute this to the ability of ions to diffuse along troughs of water density. Ion diffusion along the pore axis exhibits a general increase with channel radius in hydrophobic channels but remains fairly low in hydrophilic channels. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.480132
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  • 2
    Electronic Resource
    Electronic Resource
    Increased Arterial Stiffness in Children with a Parental History of Hypertension (1999)
    Springer
    Pediatric cardiology 20 (1999), S. 203-205 
    Details
    ISSN: 1432-1971
    Keywords: Key words: Arterial stiffness — Hypertension — Parental history — Vascular dynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The vascular dynamics of children with a parental history of hypertension has not been defined. The purpose of the current study was to determine whether or not these children have different arterial stiffness compared to the offspring of normotensive parents. One hundred healthy, nonobese subjects (ages 10–21 years) were divided into two groups of 50. Group A included the offspring of hypertensive patients and group B the offspring of normotensive parents. The variables studied were body surface area, blood pressure, and systolic and diastolic diameters of the aortic and carotid arteries as well as maximum velocity flow of these vessels. Carotid and aortic stiffness were calculated. Children and adolescents with a parental history of hypertension had higher carotid stiffness and smaller carotid diameters. These differences continued to be significant when correcting for body surface area. A higher blood pressure and a greater body surface area were also found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002469900441
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  • 3
    Electronic Resource
    Electronic Resource
    Nuclear-pore-complex dynamics and transport in higher eukaryotes (1999)
    Springer
    Protoplasma 209 (1999), S. 144-156 
    Details
    ISSN: 1615-6102
    Keywords: Nuclear-pore complex ; Nuclear transport ; Structure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The nuclear-pore complex controls the passage of macromolecules to and from the nucleus. It is a complex structure spanning the double-membrane nuclear envelope, consisting of many proteins and structural components. Structurally it consists of a series of stacked rings and associated filaments and a central cylinder which appears to contain the transport channel. Much of the pore complex appears to be dynamic, altering conformationally during transport. We review what is known about pore complex structure and dynamics and attempt to relate this to recent new information on transport pathways and the interactions of transport factors with each other and with components of the nuclear-pore complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01453443
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  • 4
    Electronic Resource
    Electronic Resource
    On nonlinear ship waves and wave resistance calculations (1999)
    Springer
    Journal of marine science and technology 4 (1999), S. 7-15 
    Details
    ISSN: 1437-8213
    Keywords: Key words: nonlinear waves ; wave resistance ; free-surface flow ; computational fluid dynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Technology
    Notes: Abstract: A finite difference method based on the Euler equations is developed for computing ship waves and wave resistances. Time marching is carried out using a time-splitting fractional-step method. The second-order central difference is used to discretize the spatial differentials, while the convection terms are discretized by the QUICK scheme. A body- and free-surface-fitted grid system with a cell-centered stencil is used. A Poisson equation for the pressure increment at each time step is solved to enforce mass conservation. The method is validated by comparing the numerical results with the experimental data for a Wigley parabolic hull. The characteristics of ship waves, such as the wave profile along the hull, the wave pattern on the free surface, the pressure distribution on the hull surface, and the wave-making resistance are reasonably predicted. The calculated results are in good agreement with the experimental data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007730050002
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  • 5
    Electronic Resource
    Electronic Resource
    PCR in situ followed by microdissection allows whole chromosome painting probes to be made from single microdissected chromosomes (1999)
    Springer
    Mammalian genome 10 (1999), S. 628-631 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Whole-chromosome painting probes (WCPs) and chromosome-arm painting probes (CAPs) are an integral part of the cytogenetic analysis of chromosome abnormalities. While these are routinely made by chromosome microdissection, multiple copies of the dissected region have been necessary to achieve a library sufficiently complex to provide adequate painting. Performing multiple dissections of chromosomes or chromosome regions is time consuming and occasionally impossible, such as when working with species whose banded karyotype is not well defined. We have developed a method whereby chromosome paints can be reliably generated by dissecting single chromosomes. The technique consists of performing degenerate oligonucleotide-primed polymerase chain reaction (DOP-PCR) in situ on the chromosomes, prior to dissection. Enough amplification occurs to enable a single dissected chromosome to be used to create a painting probe sufficiently complex for use in fluorescence in situ hybridization (FISH). The amplification products remain localized on the chromosomes; this allows region-specific chromosome paints to be made. We detail this novel technique and show whole-chromosome, arm-specific, and contiguous region-specific probes for human and rat, each created from single dissected fragments of chromatin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003359901058
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    Paper (German National Licenses)
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