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  • 2000-2004  (5)
  • 2003  (2)
  • 2000  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Magnetic and magneto-transport properties of γFe2O3-grain-embedded Fe3O4 thin films (2000)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 5585-5587 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Magnetic and magneto-transport properties of γFe2O3-grain-embedded Fe3O4 thin films are investigated. The magnetoresistance (MR) abruptly changes in the intermediate oxidation state between Fe3O4 and γFe2O3. The magnetic relaxation coefficient also becomes a minimum around this oxidation state. The slow dynamics of the magnetic relaxation are associated with the disturbance of the domain wall displacement due to the embedded γFe2O3 grains with Fe2+ impurities. A possible mechanism for the change in the MR is also proposed. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.372458
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  • 2
    Electronic Resource
    Electronic Resource
    Mitochondrial DNA sequence divergence between two cryptic species of Lethenteron, with reference to an improved identification technique (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of fish biology 62 (2003), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Genetic divergences and population structures were examined in the cryptic Lethenteron sp. N and sp. S, based on mitochondrial DNA (mtDNA) cytochrome oxidase subunit I (CO I) region sequences. An improved method of discrimination between L. sp. N and sp. S was found using PCR, with diagnostic primers for each species-specific sequence in the mtDNA CO I region. Identification of 50 individuals of each species by this analysis was consistent with that by allozyme analysis of nuclear DNA. L. sp. N and sp. S, identified on the basis of diagnostic alleles at five allozymic loci, were independently grouped in a neighbour-joining (NJ) tree, with a large sequence difference (mean ± s.d. = 9·10 ± 0·36%) between them. Within each species, the values of sequence divergence among localities were significantly higher in L. sp. S (1·61 ± 0·44%) than in L. sp. N (1·10 ± 0·48%). On the tree and nested clade analyses, several phylogenetic groups comprising geographically close localities were detected in the former, although scarcely detected in the latter, probably resulting from dispersal pattern differences between them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1095-8649.2003.00050.x
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  • 3
    Electronic Resource
    Electronic Resource
    The effects of cure of Helicobacter pylori infection on the signal transduction of gastric epithelial cells (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 18 (2003), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : The CagA protein of Helicobacter pylori is directly injected from the bacteria into cells via the bacterial type IV secretion system and undergoes tyrosine phosphorylation in the gastric epithelial cells. Translocated CagA forms a physical complex with the SRC homology 2 domain (SH2)-containing tyrosine phosphatase SHP-2, which plays an important role in mitogenic signal transduction in the host cells.Aim : We examined the effect of eradication therapy on the signal transduction pathway of gastric epithelial cells induced by the CagA protein of H. pylori.Methods : Gastric biopsy samples were obtained from 20 H. pylori-positive atrophic gastritis patients before, and 3 months after, H. pylori infection eradication therapy, and subjected to immunoblot analysis to detect tyrosine phosphorylated CagA protein and CagA co-immunoprecipitated endogenous SHP-2.Results : Tyrosine phosphorylated CagA protein and CagA co-immunoprecipitated endogenous SHP-2 were detected in the gastric mucosa from H. pylori-positive atrophic gastritis patients. All H. pylori strains from these patients were cagA-positive type I strains. After curing H. pylori infection, the tyrosine phosphorylated CagA protein and CagA co-immunoprecipitated endogenous SHP-2 disappeared from the gastric mucosa.Conclusion : The cure of infection reduces the stimulated signal transduction of gastric epithelial cells by the translocated CagA protein of H. pylori, and may confer a beneficial effect on the reduction of cancer risk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.18.s1.2.x
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  • 4
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of clarithromycin in Helicobacter pylori eradication therapy in patients with liver cirrhosis (2000)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 14 (2000), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Proton pump inhibitor triple therapy with clarithromycin and metronidazole has been widely used for Helicobacter pylori eradication. However, the efficacy and the safety of this therapy in patients with liver cirrhosis have not been established. Aim: To evaluate the effect of hepatic dysfunction on metabolism of clarithromycin as it is used for H. pylori eradication therapy in patients with liver cirrhosis, and the efficacy of eradication therapy in those patients. Methods: Serum levels of clarithromycin and its meta-bolite, 14-(R)-hydroxyclarithromycin, were examined in 18 subjects (five normal controls and 13 hospitalized patients with liver cirrhosis) on a selected day between days 7 and 10 of a 2-week course of eradication therapy. This therapy consisted of lansoprazole (30 mg, once a day) together with clarithromycin (200 mg, twice a day) and metronidazole (250 mg, twice a day). In addition, 118 H. pylori-positive out-patients, 88 with peptic ulcer and 30 with liver cirrhosis, underwent the same eradication therapy. Results: Values for the area under the 0–6 h concentration–time curve (AUC) for clarithromycin were not significantly different among the groups. However, the AUC (0–6 h) values of 14-(R)-hydroxyclarithromycin were significantly lower in the Child-Pugh C group than in either the normal controls or the Child-Pugh A/B group. The cure rate for the peptic ulcer patients was 84% on a per protocol analysis (95% CI: 80%−88%) and 81% on an intention-to-treat analysis (95% CI: 77%−85%), while in the liver cirrhosis patients it was 89% in a per protocol analysis (95% CI: 78%−99%) and 83% in an intention-to-treat analysis (95% CI: 70%−97%). Mild adverse effects were observed in 10% of the peptic ulcer patients and 13% of the liver cirrhosis patients, with none leading to premature withdrawal from the study. Conclusion: The 2-week low-dose lansoprazole-based triple therapy tested is a simple, effective and well-tolerated regimen for H. pylori eradication in patients with liver cirrhosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2000.014s1216.x
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of acrylic acid incorporation on the pressure–temperature behavior and the calorimetric properties of poly(N-isopropylacrylamide) in aqueous solutions (2000)
    Springer
    Colloid & polymer science 278 (2000), S. 80-83 
    Details
    ISSN: 1435-1536
    Keywords: Key words Poly(N-isopropylacrylamide) ; Poly(acrylic acid) ; Cloud point ; Thermoresponsive polymer ; High pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  We studied the effects of pH on the pressure–temperature dependence of coil–collapse transition for aqueous solutions of copolymers of N-isopropylacrylamide and acrylic acid (Ac). At low pressures, the transition temperature (T tr) increased with pressure, but T tr decrease with increasing pressure at pressures higher than 50–100 MPa. By increasing the pH, the transition contour shifted to a higher temperature. When the Ac content was increased, the effects of pH became more evident. From a calorimetric study at atmospheric pressure, ΔH tr was found to become smaller by increasing the portion of the ionized residues in the copolymer. The ratio to the van't Hoff enthalpy changes became larger with an increase in pH, which indicated that the production of charge decreased the cooperative domain size.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003969900231
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