Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Hydrophobic Protein that Copurifies with Human Brain Acetylcholinesterase (2000)
    Oxford UK : Blackwell Science Ltd.
    Journal of neurochemistry 74 (2000), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The mechanism of attachment of acetylcholinesterase (AChE) to neuronal membranes in interneuronal synapses is poorly understood. We have isolated, sequenced, and cloned a hydrophobic protein that copurifies with AChE from human caudate nucleus and that we propose forms a part of a complex of membrane proteins attached to this enzyme. It is a short protein of 136 amino acids and has a molecular mass of 18 kDa. The sequence contains stretches of both hydrophobic and hydrophilic amino acids and two cysteine residues. Analysis of the genomic sequence reveals that the coding region is divided among five short exons. Fluorescence in situ hybridization localizes the gene to chromosome 6p21.32-p21.2. Northern blot analysis shows that this gene is widely expressed in the brain with an expression pattern that parallels that of AChE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2000.0742146.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The influence of sample dimensions on hydroxyl ion release from calcium hydroxide products (2000)
    Copenhagen : Munksgaard International Publishers
    Dental traumatology 16 (2000), S. 0 
    Details
    ISSN: 1600-0595
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract – The purpose of this study was to compare the rate of hydroxyl ion release from commercially available setting and non-setting calcium hydroxide products. The rate of hydroxyl ion release is important, as this has been suggested to be the main factor in the therapeutic activity of these products. In total, hydroxyl ion release was measured from 1104 samples of Dycal, Life, Calasept and Hypocal in solution using in vitro titration. The rate of hydroxyl ion release was measured for up to 14 days, using two sizes of sample surface area. The dimensions of the exposed sample surface area was found to be an important physical constraint to the hydroxyl ion release from non-setting calcium hydroxide products, whereas this was not found to be the case with setting products. The range in hydroxide activity between products was found to be 298%. In rank order of hydroxide ion release, from the most to the least active was: Hypocal, Calasept, Life and Dycal. The differences in the rate of hydroxyl ion release from these products may have some implications for their clinical applications. It is suggested that in cases where the oral healing responses have been poorer than expected, the size and seal of prepared cavities could have negatively influenced the therapeutic release of hydroxyl ions from non-setting calcium hydroxide products.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-9657.2000.016006251.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Multiple basal cell carcinomas and malignant melanoma following radiotherapy for ankylosing spondylitis (2000)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 25 (2000), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We present the case of a 53-year-old Caucasian woman with seven basal cell carcinomas and one malignant melanoma in situ along her back overlying her spine, which was irradiated in 1968 for ankylosing spondylitis. These lesions developed between 1997 and 1999. She has no other known risk factors for cutaneous malignancy, in particular no history of excessive sun exposure. She has skin type 2. Molecular studies of glutathione S-transferase and cytochrome P450 status showed her genotype not to constitute an overall increased inherited susceptibility. We therefore postulate that all her skin cancers have arisen as a consequence of her radiotherapy. To our knowledge this is the first case of multiple basal cell carcinoma in addition to a malignant melanoma following radiotherapy for benign disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2230.2000.00668.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    TCR Vβ expression in the small bowel of patients with dermatitis herpetiformis and gluten sensitive enteropathy (2000)
    Copenhagen : Munksgaard International Publishers
    Experimental dermatology 9 (2000), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Dermatitis herpetiformis (DH) is a blistering skin disease characterized by cutaneous deposits of IgA and an associated, most often asymptomatic, gluten sensitive enteropathy (GSE). Gluten sensitive enteropathy is also seen in patients that do not have skin disease or cutaneous IgA deposits, but do have significant gastrointestinal (GI) complaints. Patients with DH and with GSE without skin disease have similar small bowel morphologic changes and HLA associations and both the skin disease and the GI symptoms can be controlled by a gluten free diet. It is not known what factors allow almost all patients with DH to continue to eat gluten and not develop symptomatic gastrointestinal disease. We have examined the expression of the Vβ T-cell receptor (TCR) in the small bowel of patients with DH (n=11) and of patients with both symptomatic (n=10) and asymptomatic (n=7) GSE without skin disease to determine if differences in the pattern of TCR Vβ expression are associated with differences in the clinical manifestations of these diseases. TCR Vβ expression was analyzed using RT-PCR from small bowel biopsies. Patients with DH and those with GSE without skin disease that were on a gluten free diet and asymptomatic were found to express 6.6 and 5.6 out of 20 Vβ families respectively, with no single family preference. Examination of peripheral blood lymphocytes from these patients did not reveal any restriction of TCR Vβ family expression. In contrast, patients with symptomatic GSE expressed 12.6 Vβ families (P〈 0.05), with no consistent preferential expression of any single Vβ family between patients. Patients with DH, who are continuing to ingest wheat, show a more restricted pattern of TCR Vβ utilization, similar to that of treated patients with GSE without skin disease, and significantly different from GSE without skin disease patients eating gluten. These findings suggest that the restricted nature of the TCR Vβ expression may play a role in the different clinical manifestations of dermatitis herpetiformis and isolated gluten sensitive enteropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0625.2000.009004275.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Gastrin and Colorectal Cancer (2000)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 14 (2000), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The polypeptide hormone gastrin was identified nearly a hundred years ago and its role in the regulation of acid secretion is well established. Gastrin also acts as a growth factor and is trophic for the normal gastric oxyntic mucosa. This growth promoting action has led to the extensive investigation of its role in carcinogenesis, in particular colorectal neoplasia. The relationship between gastrin and colorectal adenocarcinoma has been subject to controversy, however the findings from several recent studies have resulted in a clearer understanding of the mechanism of action of gastrin in this is common cancer.The majority of colorectal cancers produce their own gastrin, which may act in an autocrine manner. The tumour cells also express gastrin/CCKB receptors (and/or a combination of isoforms) which mediate the proliferative action. This locally produced gastrin gives rise to a small increase in systemic gastrin levels. Autocrine gastrin may also have a role in tumour development, as expression occurs early in the adenoma–carcinoma sequence. In addition, several studies using animal models have shown that systemic hypergastrinaemia promotes the proliferation of both normal and neoplastic colonic epithelium. Hyperproliferative colonic epithelium in the presence of hypergastrinaemia has been recorded in humans and a well-designed epidemiological study has demonstrated an increased incidence of colorectal cancer.Gastrin is a potential therapeutic target in the treatment of colorectal cancer and several approaches have been assessed. Receptor antagonists and antisecretory agents have been demonstrated to be ineffectual. Novel methods of inhibition, including the use of anti-gastrin antibodies, are currently being evaluated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2000.00842.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    An Evaluation of the Efficacy of In-Patient Bladder Retraining (2000)
    Springer
    International urogynecology journal 11 (2000), S. 271-276 
    Details
    ISSN: 1433-3023
    Keywords: Key words: Bladder retraining – Detrusor instability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: This is a retrospective review of 50 consecutive patients with urinary frequency, urgency and urge incontinence, admitted in 1995 and early 1996 for bladder retraining in the form of timed voiding. At discharge 80% of the women were subjectively cured or satisfactorily improved, but this was significantly reduced to 32% of the 37 who replied to a postal survey between 12 and 29 months (mean interval 21.3 months) later. There were no significant associations between outcome and urodynamic diagnosis, reduced cystometric capacity, length of symptomatology, previous treatment or requirement for additional therapy, but this may have been in part due to small numbers. In conclusion, bladder retraining is a method of treatment for patients with both sensory urgency and detrusor instability which appears to be at least as successful as other modes of treatment for these conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00004027
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Patient-assessed outcome up to three months in a randomised controlled trial comparing laparoscopic with open groin hernia repair (2000)
    Springer
    Hernia 4 (2000), S. 73-79 
    Details
    ISSN: 1248-9204
    Keywords: Inguinal hernia ; Randomised controlled trial ; Health status measures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The objective was to compare laparoscopic with open groin hernia repair in respect of patient-assessed outcome up to three months post-operatively. As part of a multicentre pragmatic trial 716 patients were recruited in 13 UK hospitals and randomly assigned to receive laparoscopic or open repair. Most participants were men (95%) with unilateral hernias (92.5%) which were inguinal (98.5%). Questionnaires were completed one week, one month, and three months after surgery. The principal endpoints were groin pain and return to usual social activities. The other outcomes were herniaspecific questions and the SF-36, EQ-5D and HADS measures. All analyses were by intention to treat. At one week and one month, respectively 10.3% and 13.9% fewer people in the laparoscopic group had groin pain and 27.7% and 37.2% fewer had numbness (all P 〈 0.001). Return to usual social activities was quicker in the laparoscopic group (P = 0.01). The laparoscopic group also had significantly more favourable scores at one week in five SF-36 subscales (physical functioning (P 〈 0.001), social functioning (P = 0.004), role physical (P 〈 0.001), role mental (P = 0.003) and pain (P 〈 0.001)), the EQ-5D utility score (P = 0.003) and the depression subscale of HADS (P = 0.001), and at one month in two SF-36 subscales (physical functioning (P = 0.01) and role physical (P = 0.01)). There was no detectable advantage by three months. Our findings that short-term outcome was better for patients allocated laparoscopic repair are consistent with other trials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02353747
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Multi-instrument study of footprints of magnetopause reconnection in the summer ionosphere (2000)
    Springer
    Annales geophysicae 18 (2000), S. 1118-1127 
    Details
    ISSN: 0992-7689
    Keywords: Ionosphere (ionosphere-magnetosphere interactions; particle precipitation; plasma temperature and density)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Results are presented from a multi-instrument investigation of the signatures of equatorial reconnection in the summer, sunlit ionosphere. Well-established ion dispersion signatures measured during three DMSP satellite passes were used to identify footprints in ionospheric observations made by radio tomography, and both the EISCAT ESR and mainland radars. Under the prevalent conditions of southward IMF with the Bz component increasing in magnitude, the reconnection footprint was seen to move equatorward through the ESR field-of-view. The most striking signature was in the electron temperatures of the F2 region measured by the EISCAT mainland radar that revealed significantly enhanced temperatures with a steep equatorward edge, in general agreement with the leading edge of the ion dispersion. It is suggested that this sharp transition in the electron temperature may be an indicator of the boundary, mapping from the reconnection site, between closed geomagnetic field lines and those opened along which magnetosheath ions precipitate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00585-000-1118-3
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Polar patches observed by ESR and their possible origin in the cusp region (2000)
    Springer
    Annales geophysicae 18 (2000), S. 1043-1053 
    Details
    ISSN: 0992-7689
    Keywords: Ionosphere (ionosphere–magnetosphere interactions; plasma temperature and density; polar ionosphere)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Observations by the EISCAT Svalbard radar in summer have revealed electron density enhancements in the magnetic noon sector under conditions of IMF Bz southward. The features were identified as possible candidates for polar-cap patches drifting anti-Sunward with the plasma flow. Supporting measurements by the EISCAT mainland radar, the CUTLASS radar and DMSP satellites, in a multi-instrument study, suggested that the origin of the structures lay upstream at lower latitudes, with the modulation in density being attributed to variability in soft-particle precipitation in the cusp region. It is proposed that the variations in precipitation may be linked to changes in the location of the reconnection site at the magnetopause, which in turn results in changes in the energy distribution of the precipitating particles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00585-000-1043-5
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Dayside ionospheric response to changes in IMF polarity: optical and plasma-flow observations (2000)
    Springer
    Annales geophysicae 18 (2000), S. 782-788 
    Details
    ISSN: 0992-7689
    Keywords: Ionosphere (ionosphere-magnetosphere interactions) ; Magnetospheric physics (magnetosphere-ionosphere interactions; polar cap phenomena)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The response of the dayside ionosphere to changes in polarity of the interplanetary magnetic field was observed by two independent techniques. The signatures were seen in the 630.0 nm red-line emission, measured by a meridian scanning photometer at Ny-Ålesund on Svalbard, and also in the line-of-sight plasma velocities monitored by the Finland CUTLASS SuperDARN radar. A time difference of some 6 to 8 min occurred between the responses of the two techniques, with the flows being first to respond. In the present case study, the longer delay in the optics suggests that ion precipitation controls the auroral emission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00585-000-0782-7
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...