Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Deuteron and carbon magnetic resonance studies of supercooled liquid and glassy salol (2000)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 112 (2000), S. 5884-5892 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The glass-former salol was studied using carbon and deuteron NMR. For the 13C measurements protonated samples were used. For the deuteron experiments salol was selectively deuterated at the phenyl ring. The measurement of the spin-lattice relaxation times provides clear evidence for an anisotropic reorientation of the molecules in the supercooled liquid. Close to the glass transition a bimodal longitudinal magnetization recovery is observed which indicates the presence of relatively slow intramolecular degrees of freedom. From deuteron solid echo spectra this process is identified as a uniaxial large amplitude motion of the phenyl group which exhibits a broad distribution of correlation times. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.481161
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Structural relaxation of the fragile glass-former propylene carbonate studied by nuclear magnetic resonance (2000)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 112 (2000), S. 9455-9462 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Proton, deuteron, and carbon NMR methods were applied to study various isotopic species of supercooled and glassy propylene carbonate. The molecular diffusion was investigated via static field gradient diffusometry and yielded evidence for a particularly pronounced enhancement of the translational over the reorientational dynamics. The latter was monitored using measurements of spin-lattice relaxation times and of two-time stimulated echoes. The sin–sin correlation functions exhibited a pronounced dependence on the evolution times. From these results it is concluded that the geometry of molecular reorientation can be described as a superposition of moderately small jump angles (about 30°) and a quasi-diffusive component which is responsible for about one-third of the total angular displacement. Finally, four-time stimulated echoes confirmed that the nonexponential relaxation in propylene carbonate is dynamically heterogeneous in nature. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.481588
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Different initiation of pre-TCR and γδTCR signalling (2000)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 406 (2000), S. 524-527 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Lineage choice is of great interest in developmental biology. In the immune system, the αβ and γδ lineages of T lymphocytes diverge during the course of the β-, γ- and δ-chain rearrangement of T-cell receptor (TCR) genes that takes place within the same ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35020093
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Strahlentherapie von Fernmetastasen urologischer Malignome (2000)
    Springer
    Der Urologe 39 (2000), S. 133-140 
    Details
    ISSN: 1433-0563
    Keywords: Schlüsselwörter Metastasen • Strahlentherapie • Hirnmetastasen • Knochenmetastasen • Lebensqualität ; Key words Metastases • Radiotherapy • Brain metastases • Bone metastases • Quality of life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The largest subgroup of patients with metastasised urological malignancies are those with metastases of the bone. Lesions of bones frequently reduce the patients quality of life. Therefore a sufficient therapy is crucial. First of all the appropriate diagnostic procedure of the lesion/lesions is necessary because e the right choice of diagnostic measures may already improve quality of life. Besides the most frequently used local irradiation a systemic radiotherapy may be the adequate therapy in patients with disseminated disease. Renal cell-, bladder and penile cancer respectively are the urological malignancies frequently metastasising into the brain. Adequate diagnostic procedures and therapy are crucial to the patients quality of life for the remaining lifetime. Besides a whole brain irradiation as standard therapy stereotactic radiotherapy is a high precision tool to destroy intracerebral tumour. There are many other locations of metastatic disease (i. e. lymph node or soft tissue metastasis, et cetera) where palliative external beam irradiation may provide relief from symptoms such as pain, lymph oedema or bleeding and thus increase quality of life. Psychological and social care are of great value besides symptom oriented therapy (i. e. radiotherapy, drugs, et cetera) to achieve an optimal palliation/quality of life.
    Notes: Zusammenfassung Patienten mit Knochenmetastasen bilden die größte Gruppe der Patienten mit urologischen Tumoren im metastasierten Stadium. Da ossäre Läsionen häufig die Lebensqualität deutlich einschränken, ist eine suffiziente Therapie von entscheidender Bedeutung. Zunächst ist die korrekte Diagnostik der Läsion/Läsionen notwendig. Hier kann schon durch die Wahl des geeigneten diagnostischen Verfahrens Lebensqualität gewonnen werden. Neben der am häufigsten eingesetzten lokalen Bestrahlung ist auch eine systemische Radiatio besonders bei disseminierter Erkrankung möglich. Urothel-, Blasen und Peniskarzinomen stellen die urologischen Malignome, bei denen es zu Hirnmetastasen kommen kann. Auch hier ist die adäquate Diagnostik ausschlaggebend für die Lebensqualität in der verbleibenden Lebenszeit des Patienten. Neben einer Ganzhirnbestrahlung ist die stereotaktische Radiatio als Hochpräzisionsbestrahlung zu nennen, die eine effektive Maßnahme zur Tumorvernichtung darstellt. Auch bei anderen Metastasen urologischer Tumore (Lymphknoten, Weichteilmetastasen, etc) ist durch eine palliative Strahlentherapie ein Gewinn an Lebensqualität möglich und Symptome wie Schmerzen, Lymphödem oder Blutung können effektiv gelindert werden. Neben der symptomorientierten Therapie (Radiatio, Medikamente, etc) ist die psychosoziale Betreuung für eine optimale Palliation/Lebensqualität von großer Bedeutung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001200050021
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Calcium Supplementation with Calcium-Rich Mineral Waters: A Systematic Review and Meta-analysis of its Bioavailability (2000)
    Springer
    Osteoporosis international 11 (2000), S. 938-943 
    Details
    ISSN: 1433-2965
    Keywords: Key words:Bioavailability – Calcium – Mineral water – Osteoporosis – Recommended daily allowance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The relevance of calcium (Ca2+), an essential bone mineral, to the prevention and treatment of osteoporosis is well established. However, a good deal of evidence casts doubt on the validity of current RDAs (recommended daily allowance), i.e., 800–1000 mg/day. New guidelines consistently advocate higher daily intakes (up to 1500 mg/day), a goal that may be difficult to achieve for many patients. Environmental as well as individual behavioral factors may limit the consumption of dairy products, whereas calcium supplements require a high level of compliance and cause additional costs. Calcium-rich mineral waters may offer a promising alternative. A systematic literature search was performed (Medline, years 1966–1998) to identify experimental studies on the bioavailability of calcium-rich mineral waters. First, all publications on calcium absorption from mineral waters were identified, and, in a second step, studies comparing calcium absorption from mineral waters with that from dairy products. Four studies fulfilled all inclusion criteria. A meta-analysis based on published p values indicated calcium absorption from mineral waters was significantly higher (p= 0.03) than that from dairy products. Although only few studies with a relatively small number of subjects are available to date, the bioavailability of calcium from calcium-rich mineral waters thus seems to be at least comparable to, and possibly better than, that from dairy products. These results are in keeping with the assumption that calcium-rich mineral water is a useful calcium source to achieve new, higher recommended daily allowances of calcium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001980070032
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Radiotherapie des Prostatakarzinoms (2000)
    Springer
    Der Onkologe 6 (2000), S. 130-136 
    Details
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Das Prostatakarzinom ist die zweithäufigste Krebserkrankung bei Männern in Deutschland und die Ursache für 13,5% aller bösartigen Erkrankungen. In den Vereinigten Staaten von Amerika liegt diese Rate sogar bei 30%. Ätiologisch sind nur wenige Faktoren bekannt, die das Auftreten eines Prostatakarzinoms begünstigen. Als gesichert gelten ethnische Unterschiede mit einem erhöhten Risiko für Afro-Amerikaner gegenüber Weißen, Chinesen oder Japanern. Eine signifikante Erhöhung des Risikos für die Erkrankung an einem Prostatakarzinom wurde außerdem bei Männern mit einer positiven Familienanamnese berichtet [1, 28]. Als ein weiterer Risikofaktor werden Ernährungsgewohnheiten angesehen, wobei fette, ballaststoffarme Ernährung und ein hoher Body-Mass-Index mit einem erhöhten Risiko für die Erkrankung einhergeht [13, 17].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007610050025
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Stellenwert der Strahlentherapie in der Urologie (2000)
    Springer
    Der Urologe 39 (2000), S. 120-125 
    Details
    ISSN: 1433-0563
    Keywords: Schlüsselwörter Prostatakarzinom • Strahlentherapie • Brachytherapie • Interstitielle Therapie ; Key words Prostate cancer • Radiotherapy • Brachytherapy • Interstitial therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Radiotherapy of patients with prostate cancer offers an alternative to radical prostatectomy in early stages (T1–T2). In locally advanced prostate cancer a high dose or combined radiotherapy is more effective than radical surgery with concurrent lower morbidity and mortality. Recent developments in linear accellerator technique, the progress in dose calculation and planning techniques provide the means to apply higher doses to a given tumor volume while effectively protecting the surrounding normal tissue at the same time. These improvements may possibly reduce the rate of therapy related side effects or complications significantly. The combination of external beam radiotherapy and interstitial brachytherapy as well as the combination of hormone therapy and external beam radiotherapy are most likely more effective than percutaneous irradiation alone. In special cases with a very low risk of recurrent tumor an interstitial permanent brachytherapy alone is indicated. Future developments (i. e. intensity modulated radiotherapy – IMRT, combined thermo-radiotherapy, proton- or neutrontherapy) may further increase the rate of curative treatments in patients with prostate cancer.
    Notes: Zusammenfassung Die Strahlentherapie von Patienten mit Prostatakarzinomen bietet eine gleichwertige Alternative zur radikalen Prostatektomie in frühen Stadien (T1–T2). Beim lokal fortgeschrittenen Prostatakarzinom ist eine hochdosierte oder kombinierte Strahlentherapie effektiver als eine Radikaloperation bei geringerer Morbidität und Mortalität. Durch die Entwicklung neuer Linearbeschleuniger und Fortschritte in der Bestrahlungsplanung mit besseren Bestrahlungstechniken ist es heute möglich, höhere Bestrahlungsdosen zu applizieren und gleichzeitig das umgebende, gesunde Gewebe besser zu schonen. Somit ist es möglich, daß die Rate von therapiebedingten Komplikationen konstant bleibt oder absinkt. Die Kombination von perkutaner Radiatio mit interstitieller Brachytherapie ebenso wie die Kombination von Hormontherapie mit perkutaner Radiatio sind möglicherweise effektiver als die alleinige perkutane Radiatio. In ausgewählten Fällen mit niedrigem Risiko ist eine alleinige, interstitielle, permanente Brachytherapie angezeigt. Zukünftige Entwicklungen (IMRT, kombinierte Thermo-Radio-Therapie, Protonen- oder Neutronentherapien) können möglicherweise die Rate kurativ behandelter Patienten weiter erhöhen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001200050019
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Verletzungen des thorakolumbalen Übergangs (2000)
    Springer
    Trauma und Berufskrankheit 2 (2000), S. 162-166 
    Details
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Thorakolumbale Frakturen ; Transpedikuläre Spondylodese ; Spongiosaplastik ; Komplikationen ; Keywords ; Thoracolumbar fractures ; Transpedicular spondylodesis ; Bone grafting ; Complications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Spinal fractures are located predominantly at the thoracolumbar junction. After conservative treatment, for unstable fractures operative procedures were established during the last 20 years. Using implants with angular stability, dorsal transpedicular fixation yields good clinical results even compared with those of combined dorsoventral procedures. Transpedicular bone grafting is controversial as resorption frequently occurs; it has given disappointing results in fracture types in which definitive segmental fusion is unavoidable, so that combined dorso-ventral stabilization is necessary in such cases. The most frequent complications of dorsal instrumentation are the result of badly positioned transpedicular screws.
    Notes: Die Verletzungen des thorakolumbalen Übergangs stellen die Mehrzahl der Frakturen der Wirbelsäule dar. Nach der konservativen Therapie hat sich in den letzten beiden Jahrzehnten die operative Versorgung instabiler Frakturen etabliert. Die dorsale transpedikuläre Spondylodese unter Verwendung winkelstabiler Implantate stellt ein Verfahren dar, mit dem sich auch im Vergleich zu aufwändigen dorsoventralen Rekonstruktionen bei den meisten Frakturen gute klinische Resultate erzielen lassen. Der additionellen transpedikulären intrakorporalen Spongiosaplastik wird aufgrund der zu beobachtenden Resorption des Transplantats zunehmend geringere Bedeutung beigemessen. Auch bei Frakturtypen, bei denen eine definitive Fusion angestrebt werden sollte, hat die transpedikuläre interkorporale Knochentransplantation enttäuscht, sodass in derartigen Fällen nach primärer dorsaler Stabilisierung sekundär die Fusion von ventral erfolgen sollte. Die häufigsten Komplikationen bei der dorsalen transpedikulären Spondylodese sind auf Fehllagen der transpedikulären Schrauben zurückzuführen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00010931
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Incorporation of Pigments in TEOS Derived Matrices (2000)
    Springer
    Journal of sol gel science and technology 19 (2000), S. 361-364 
    Details
    ISSN: 1573-4846
    Keywords: TEOS ; pigments ; lightfastness ; pencil hardness ; transparency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Small organic pigments were incorporated in TEOS derived sol-gel layers on glass. The layers were characterised on transparency, lightfastness and pencil hardness. It was found that transparent layers can be made. Pigment loaded layers have a better lightfastness than layers into which dyes are incorporated. As only moderate curing temperatures (160°C) were applied, the organic fraction originating from the organic stabilizer present in the pigment dispersion remains to a large extent in the layer. Therefore the pencil hardness decreases with the amount of stabilizer used to disperse the pigment particles. The type of pigment has no influence on the pencil hardness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008766506663
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    PDGF receptor kinase blocker AG1295 attenuates interstitial fibrosis in rat kidney after unilateral obstruction (2000)
    Springer
    Cell & tissue research 299 (2000), S. 97-103 
    Details
    ISSN: 1432-0878
    Keywords: PDGF receptor kinase blocker AG1295 Interstitial fibrosis Kidney Immunohistochemistry Rat (Sprague Dawley)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The current study was designed to investigate possible effects of the platelet-derived growth factor (PDGF) receptor kinase blocker AG1295 on the development of interstitial fibrosis in rats with unilateral ureteral obstruction (UUO), monitored by ED-A+ fibronectin expression, the number of macrophages, and the presence of myofibroblasts as visualized by immunohistochemistry with monoclonal antibodies (mAb) IST9, mAb ED1, and mAb 1A4, respectively; interstitial fibrosis was quantified by Sirius-Red staining and computer-aided image analysis. Without AG1295 treatment, the Sirius-Red stained area of the control kidneys comprised 6.8±1.3% of the totally inspected area and increased to 19.0±1.9% in animals by 14 days and to 23.4±1.7% by 21 days after UUO. The number of macrophages increased from 4.3±1.1 in controls to 16.6±2.6 in animals at 14 days and to 23.2±4.4 at 21 days after UUO. This was accompanied by an increase in both ED-A+ fibronectin deposition and α-smooth muscle actin expression. Treatment with AG1295 (12 mg/kg body weight, daily i.p.) significantly reduced interstitial fibrosis as verified by a smaller Sirius-Red stained area (15.7±1.9% in animals at 14 days and 17.0±0.7% at 21 days after UUO) and also by a reduced number of macrophages (12.8±1.4 in animals at 14 days and 15.5±3.8 at 21 days after UUO), and by the ED-A+ fibronectin deposition and the number of cells positive for α-smooth muscle actin. The study indicates that the PDGF receptor kinase blocker AG1295 is able to decrease interstitial fibrosis in the rat UUO model significantly. The diminution of early fibrosis mediators, i.e., macrophages, ED-A+ fibronectin, and myofibroblast phenotype, points to a modulated fibrosis process via a blockade of PDGF actions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004419900118
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...