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Region-Specific Enhancement of Basal Extracellular and Cocaine-Evoked Dopamine Levels Following Constitutive Deletion if tge Seritibub1B Receptor (2000)

Shippenberg, T. S. ; Hen, R. ; He, M.

Oxford UK : Blackwell Science Ltd.

Journal of neurochemistry 75 (2000), S. 0

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ISSN: 1471-4159

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Abstract : The behavioral effects of cocaine are enhanced following constitutive deletion of the serotonin1B receptor. The neural substrates mediating the enhanced response to cocaine are unknown. The present studies determined whether basal dopamine dynamics or cocaine-evoked dopamine levels are altered in projection areas of mesostriatal or mesoaccumbens dopamine neurons following serotonin1B receptor deletion. Male wild-type and serotonin1B knockout mice were implanted with microdialysis guide cannulas aimed at the dorsal striatum or nucleus accumbens. The zero net flux method of quantitative microdialysis was used to quantify basal extracellular dopamine concentrations (DAext) and the extraction fraction of dopamine (Ed), which provides an index of dopamine uptake. Conventional microdialysis techniques were used to quantify cocaine (0, 5.0, and 20.0 mg/kg)-evoked dopamine overflow. Basal DAext and Ed did not differ in striatum of wild-type and knockout mice. Similarly, cocaine-stimulated dopamine overflow did not differ between genotype. The basal Ed did not differ in the nucleus accumbens of wild-type and knockout mice. However, DAext was significantly elevated in the nucleus accumbens of knockout mice. Cocaine-evoked dopamine overflow (nM) was also enhanced in the nucleus accumbens of knockout mice. However, the cocaine-induced increase in dopamine levels, relative to basal values, did not differ between genotype. These data demonstrate that deletion of the serotonin1B receptor is associated with increases in basal DAext in the nucleus accumbens. This increase is not associated with an alteration in Ed, suggesting increased basal dopamine release in these animals. It is hypothesized that these alterations in presynaptic neuronal activity are a compensatory response to constitutive deletion of the serotonin1B receptor and may contribute to the enhanced behavioral effects of psychostimulants observed in knockout mice.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1046/j.1471-4159.2000.0750258.x

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Synthesis of aligned gallium nitride nanowire quasi-arrays (2000)

Li, J.Y. ; Chen, X.L. ; Qiao, Z.Y. ; [et al.]

Springer

Applied physics 71 (2000), S. 349-350

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ISSN: 1432-0630

Keywords: PACS: 81.05.Ea

Source: Springer Online Journal Archives 1860-2000

Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics

Notes: Abstract. Self-aligned GaN nanowire quasi-arrays were synthesized on MgO crystal through a simple gas reaction method. They were characterized by powder X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray (EDX) spectroscopy and high-resolution transmission electron microscopy (HRTEM). FE-SEMimages showed that the product consisted of quasi-arrays of nanowires. XRD, EDX and HRTEM indicated that the nanowires were wurtzite GaN single crystals.