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  • 2000-2004  (2)
  • 1985-1989
  • 1915-1919
  • 2001  (2)
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  • 2000-2004  (2)
  • 1985-1989
  • 1915-1919
Year
  • 1
    Electronic Resource
    Electronic Resource
    Solute-binding protein-dependent ABC transporters are responsible for solute efflux in addition to solute uptake (2001)
    Oxford, UK : Blackwell Science, Ltd
    Molecular microbiology 40 (2001), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The ATP-binding cassette (ABC) transporter superfamily is one of the most widespread of all gene families and currently has in excess of 1100 members in organisms ranging from the Archaea to man. The movement of the diverse solutes of ABC transporters has been accepted as being strictly unidirectional, with recent models indicating that they are irreversible. However, contrary to this paradigm, we show that three solute-binding protein-dependent (SBP) ABC transporters of amino acids, i.e. the general amino acid permease (Aap) and the branched-chain amino acid permease (Bra) of Rhizobium leguminosarum and the histidine permease (His) of Salmonella typhimurium, are bidirectional, being responsible for efflux in addition to the uptake of solutes. The net solute movement measured for an ABC transporter depends on the rates of uptake and efflux, which are independent; a plateau is reached when both are saturated. SBP ABC transporters promote active uptake because, although the Vmax values for uptake and efflux are not significantly different, there is a 103−104 higher affinity for uptake of solute compared with efflux. Therefore, the SBP ABC transporters are able to support a substantial concentration gradient and provide a net uptake of solutes into bacterial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2958.2001.02497.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Environmental Performance Indicators: The Water Industry of England and Wales (2001)
    Oxford, UK : Blackwell Publishing Ltd
    Water and environment journal 15 (2001), S. 0 
    Details
    ISSN: 1747-6593
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Water companies in England and Wales produce reports using environmental performance indicators which have been developed in-house. However, there is no recognised methodology for the development of these indicators, and an analysis of available guidance led to the proposal of an appropriate model. This model was tested by semi-structured interviews of water-company managers, and a questionnaire was completed by managers from other industries. The responses from the interviews supported the inclusive, quality-driven approach advocated by the model, and indicated a need to examine (a) the style of management, (b) the staffing structure in water companies, (c) the connection between environmental management systems and indicator development, (d) types of objectives and targets, and (e) the use of indicators as public-relations tools. The result is a methodology for indicator development which can be applied by managers in industry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1747-6593.2001.tb00302.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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