ISSN:
1398-9995
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Background: Previous studies have shown elevated serum levels of the cytokines IL-4 and sCD23 in atopic patients and parasitic disease. Gastroall_ergic anisakiasis is an acute parasitic disease, accompanied by IgE-mediated clinical symptoms and an important increase of specific and total IgE. Methods: Sixteen patients with acute urticaria/angioedema due to parasitism by Anisakis simplex after intake of raw or undercooked fish were selected, and serum samples were taken in the emergency room within 24 h (day 0; n=16), after 1 month (n=16), and after 6 months (n=10). Serum samples were studied for specific IgE against A. simplex, total IgE, sCD23, and IL-4. Results: Mean values for sCD23 did not change in the observation period. Only 4/16 serum samples showed measurable IL-4 levels. Specific IgE and total IgE levels were found to be elevated after 1 month; after 6 months, they fell to nearly basal values. There was a positive correlation between sCD23 and specific IgE at day 0 and follow-up (r=0.55–0.69, P〈0.026); a positive correlation beween sCD23 and total IgE (r=0.54–0.62, P〈0.056). Basal sCD23 could moderately predict the percentual increment of total IgE in the first month (r=0.56, P〈0.038). Conclusions: Thus, it seems that interindividual variability of sCD23 is an important factor, with higher values predisposing to more production of unrelated IgE, independently of the parasite's action.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1034/j.1398-9995.2001.00207.x
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