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  • 1
    Electronic Resource
    Electronic Resource
    The utility of cytokeratin subsets in distinguishing Barrett's-related oesophageal adenocarcinoma from gastric adenocarcinoma (2001)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 38 (2001), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims: Accurate tumour classification is critical for meaningful epidemiological studies in the assessment of cancer incidence rates and trends. Differentiating primary gastric carcinoma from oesophageal carcinoma can be difficult, especially when tumours are large and involve both the oesophagus and stomach. Furthermore, adenocarcinomas of both organs typically are of intestinal histological type and arise in a background of intestinal metaplasia. Consequently, histological markers that reliably distinguish Barrett's-related oesophageal adenocarcinoma from gastric adenocarcinoma would be useful. Cytokeratins (CK)7 and 20 are cytoplasmic structural proteins with restricted expression that help to determine the origin of many epithelial tumours including those of the gastrointestinal tract. The aim of this study was to determine the utility of co-ordinate CK7 and 20 expression in the distinction of Barrett's-related oesophageal adenocarcinoma from gastric adenocarcinoma arising in a background of intestinal metaplasia.Methods and results: CK7 and 20 immunostaining was performed on randomly selected surgical resection specimens from patients with Barrett's-related oesophageal adenocarcinoma (n = 30) and intestinal type gastric adenocarcinoma (n = 14) arising in a background of intestinal metaplasia. A CK7+ CK20- immunophenotype was demonstrated in 27 of 30 (90%) patients with Barrett's-related oesophageal adenocarcinoma and only three of 14 (21%) gastric adenocarcinomas. The sensitivity, specificity and positive predictive value of a CK7+/20– immunophenotype for a diagnosis of Barrett's-related oesophageal adenocarcinoma was 90%, 79%, and 90%, respectively.Conclusions: A CK7+/20– tumour immunophenotype is associated with Barrett's-related oesophageal adenocarcinoma and may be useful in accurate tumour classification, thus facilitating improving epidemiological evaluation of tumours at the oesophagogastric junction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.2001.01079.x
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  • 2
    Electronic Resource
    Electronic Resource
    Ambulatory gastric pH monitoring: proper probe placement and normal values (2001)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 15 (2001), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: : Gastric acid production may persist while patients are treated with proton pump inhibitors. Twenty-four-hour intragastric pH monitoring is being used to identify gastric acid in the stomach while on medical therapy.〈section xml:id="abs1-2"〉〈title type="main"〉Aim: To identify the optimal region of the stomach to demonstrate the presence of gastric acid.〈section xml:id="abs1-3"〉〈title type="main"〉Method: Probe locations confirmed with fluoroscopy after placement and prior to removal. In experiment 1, five volunteers underwent simultaneous, 24-h gastro-oesophageal pH monitoring with the pH sensors located in the gastric antrum, body, fundus and distal oesophagus. In experiment 2, five volunteers underwent simultaneous 24-h pH monitoring with sensors located side by side in the gastric fundus assessing the reproducibility of gastric pH in this region. In experiment 3, 35 volunteers underwent 24-h pH monitoring with pH sensors located in the distal oesophagus and gastric fundus. The mean percentage time for which pH 〈 4 was calculated for total, upright, and supine time periods. Results: pH profiles for the gastric fundus and body are similar—the mean percentage total time for which pH 〈 4 was 92.2% and 90.1%, respectively (P=N.S.). These values are significantly different from the antrum; pH 〈 4=54.6% (P 〈 0.01). pH values from the gastric fundus are highly reproducible (linear regression P= 0.004, r2=0.96). The normal values (mean ± 95th percentile) for percentage time gastric pH 〈 4 in the fundus were: total 95.6 ± 1.5%, upright 94.8 ± 1.8%, and supine 96.5 ± 2.3%.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusion: The fundus is the optimal location to evaluate the presence of gastric acid; pH values are highly reproducible in this area. Normal values for percentage time gastric pH 〈 4 for a healthy population are now defined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2001.01011.x
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  • 3
    Electronic Resource
    Electronic Resource
    Exact diagonalization of the S = 1/2 XY ferromagnet on finite bcc lattices to estimate T = 0 properties on the infinite lattice (2001)
    Springer
    The European physical journal 21 (2001), S. 191-204 
    Details
    ISSN: 1434-6036
    Keywords: PACS. 05.50.+q Lattice theory and statistics (Ising, Potts, etc.) – 75.10.Jm Quantized spin models – 75.50.Dd Nonmetallic ferromagnetic materials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: In this paper finite bcc lattices are defined by a triple of vectors in two different ways - upper triangular lattice form and compact form. In Appendix A are lists of some 260 distinct and useful bcc lattices of 9 to 32 vertices. The energy and magnetization of the S = 1/2 XY ferromagnet have been computed on these bcc lattices in the lowest states for S z = 0, 1/2, 1 and 3/2. These data are studied statistically to fit the first three terms of the appropriate finite lattice scaling equations. Our estimates of the T = 0 energy and magnetization agree very well with spin wave and series expansion estimates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100510170195
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  • 4
    Electronic Resource
    Electronic Resource
    Independent magnon states on magnetic polytopes (2001)
    Springer
    The European physical journal 24 (2001), S. 475-481 
    Details
    ISSN: 1434-6036
    Keywords: PACS. 75.50.Xx Molecular magnets – 75.10.Jm Quantized spin models – 75.40.Cx Static properties (order parameter, static susceptibility, heat capacities, critical exponents, etc.)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: For many spin systems with constant isotropic antiferromagnetic next-neighbour Heisenberg coupling the minimal energies E min(S) form a rotational band, i.e. depend approximately quadratically on the total spin quantum number S, a property which is also known as Landé interval rule. However, we find that for certain coupling topologies, including recently synthesised icosidodecahedral structures this rule is violated for high total spins. Instead the minimal energies are a linear function of total spin. This anomaly results in a corresponding jump of the magnetisation curve which otherwise would be a regular staircase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s10051-001-8701-6
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    Paper (German National Licenses)
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