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  • 2000-2004  (41)
  • 1955-1959
  • 2003  (26)
  • 2002  (15)
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  • 2000-2004  (41)
  • 1955-1959
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  • 1
    E-Resource
    E-Resource
    Interactive knee (2003)
    London :Primal Pictures,
    Details
    Title: Interactive knee
    Contributer: Aichroth, Paul M.
    Edition: Version 1.1
    Publisher: London :Primal Pictures,
    Year of publication: 2003
    Pages: 1 CD-ROM 12 cm
    Series Statement: Primal 3D interactive series
    Type of Medium: Electronic Resource
    Language: English
    Note: Systemvoraussetzungen PC: Windows95, 98, 2000 or NT 4.0 Pentium; Min 32 Mb RAM , Systemvoraussetzungen MAC: Mac OS 7.1 or newer; Min 20 Mb RAM; 16 bit colour; 604 processor upwards
    Library Location Call Number Volume/Issue/Year Availability
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    ZIB Catalog
    Zuse Institute Berlin get availability status
  • 2
    Electronic Resource
    Electronic Resource
    Benchmark Dose Risk Assessment for Formaldehyde Using Airflow Modeling and a Single-Compartment, DNA-Protein Cross-Link Dosimetry Model to Estimate Human Equivalent Doses (2003)
    350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Publishing Inc.
    Risk analysis 23 (2003), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Formaldehyde induced squamous-cell carcinomas in the nasal passages of F344 rats in two inhalation bioassays at exposure levels of 6 ppm and above. Increases in rates of cell proliferation were measured by T. M. Monticello and colleagues at exposure levels of 0.7 ppm and above in the same tissues from which tumors arose. A risk assessment for formaldehyde was conducted at the CIIT Centers for Health Research, in collaboration with investigators from Toxicological Excellence in Risk Assessment (TERA) and the U.S. Environmental Protection Agency (U.S. EPA) in 1999. Two methods for dose-response assessment were used: a full biologically based modeling approach and a statistically oriented analysis by benchmark dose (BMD) method. This article presents the later approach, the purpose of which is to combine BMD and pharmacokinetic modeling to estimate human cancer risks from formaldehyde exposure. BMD analysis was used to identify points of departure (exposure levels) for low-dose extrapolation in rats for both tumor and the cell proliferation endpoints. The benchmark concentrations for induced cell proliferation were lower than for tumors. These concentrations were extrapolated to humans using two mechanistic models. One model used computational fluid dynamics (CFD) alone to determine rates of delivery of inhaled formaldehyde to the nasal lining. The second model combined the CFD method with a pharmacokinetic model to predict tissue dose with formaldehyde-induced DNA-protein cross-links (DPX) as a dose metric. Both extrapolation methods gave similar results, and the predicted cancer risk in humans at low exposure levels was found to be similar to that from a risk assessment conducted by the U.S. EPA in 1991. Use of the mechanistically based extrapolation models lends greater certainty to these risk estimates than previous approaches and also identifies the uncertainty in the measured dose-response relationship for cell proliferation at low exposure levels, the dose-response relationship for DPX in monkeys, and the choice between linear and nonlinear methods of extrapolation as key remaining sources of uncertainty.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1539-6924.00328
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Propagation of a Long-Lived and Threatened Prairie Plant, Lupinus sulphureus ssp. kincaidii (2003)
    Boston, MA, USA : Blackwell Science Inc
    Restoration ecology 11 (2003), S. 0 
    Details
    ISSN: 1526-100X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Willamette Valley upland prairie in western Oregon, U.S.A. has been severely degraded and fragmented in the past 150 years after European settlement, resulting in vast population reductions of endemic species. Icaricia icarioides fenderi (Fender's blue butterfly) and Lupinus sulphureus ssp. kincaidii (Kincaid's lupine) are federally listed as Endangered and Threatened Species, respectively. Both are Willamette Valley upland prairie endemics, and Kincaid's lupine is the primary host plant for the Fender's blue butterfly. Attempts to grow Kincaid's lupine have been partially successful in a greenhouse situation; however, propagating plants from field-sown seed can be tenuous and plant establishment is unpredictable. Kincaid's lupine seeds were planted in the fall 1997 at two different upland prairie sites, and the cohort was followed through the summer 2000. Based on cohort tables the most vulnerable life stages to mortality are the germinant stage and the first growing year. Mechanical scarification of Kincaid's lupine seeds yielded no significant differences in survivorship, maternal function, plant size, and the percentage of seeds germinated compared with unscarified seeds. Differential seed source performance detected at one planting site suggests that underlying differences in population genetics may affect Kincaid's lupine vigor, fitness, and establishment. Future restoration projects for Kincaid's lupine should focus on upland prairie sites with naturally occurring lupine populations because local ecological conditions are favorable for lupine establishment. Moreover, the addition of new individuals to small Kincaid's lupine colonies will buffer against the effects of inbreeding depression and increase the site carrying capacity for Fender's blue butterfly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1526-100X.2003.00175.x
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Restoration of Hydrastis canadensis by Transplanting with Disturbance Simulation: Results of One Growing Season (2003)
    Boston, MA, USA : Blackwell Science Inc
    Restoration ecology 11 (2003), S. 0 
    Details
    ISSN: 1526-100X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Having evolved in an environment with large, severe, and frequent disturbances, including massive floods, fires, and impacts of extinct and extirpated fauna, woodland herbs may be adapted to such disturbance processes. Present lack of such disturbances may contribute to present rarity. We test the hypothesis that transplanting with disturbance simulation can be used to restore the threatened woodland herb, Hydrastis canadensis (goldenseal). Three disturbance-simulation treatments (soil turnover, fertilization, and both) and a control were randomly applied to 100 blocks in goldenseal habitat, and a single rhizome was transplanted into each treatment. Transplanting was effective with 85% of the transplants surviving, 41% flowering, and 34% fruiting; thus, transplanting may increase area of occupancy. Soil turnover alone and combined with fertilization caused a significant increase in plant size available to support production of fruit. Increased flower and significantly increased fruit production were also characteristic of soil-turned plots. Results support the hypothesis that some woodland herbs are rare due to lack of certain disturbance, call for consideration of soil disturbance as a potentially important and beneficial influence on woodland herbs regardless of light effects, and suggest that transplanting into soil-overturned plots may restore goldenseal. The assumption that undisturbed conditions are optimal may impede effective management of rare woodland flora, highlighting the need for a more flexible approach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1526-100X.2003.00183.x
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Injury-induced ‘switch’ from GTP-regulated to novel GTP-independent isoform of tissue transglutaminase in the rat spinal cord (2002)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 81 (2002), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We recently found that alternative transcripts of tissue transglutaminase (tTG or TG2) were present in hippocampal brain regions of Alzheimer's disease (AD), but not in control, non-demented, age-matched brains. Since antecedent non-severe trauma has been implicated in AD and other neurodegenerative diseases, such as Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), we were interested in whether alternative transcripts might be detected in a model of neurotrauma, controlled-contusion spinal cord injury (SCI) in the rat. Implicated in diverse roles from growth and differentiation to apoptotic cell death, only bifunctional tTG, of the nine member TG family, has dual catalytic activities: guanine trinucleotide (GTP) hydrolyzing activity (GTPase), as well as protein cross-linking. These functions imply two physiological functions: programmed cell life and death. These may have profound roles in the nervous system since studies in cultured astrocytes found tTG short (S) mRNA transcripts induced by treatment with injury-related cytokines. In the developing rat spinal cord, tTG activity is concentrated in ventral horn alpha motoneurons, but neither studies of spinal cord tTG gene expression, nor evaluation of the GTP-regulated isoforms in tissues, have been reported. We now report increased tTG protein and gene expression occurring rapidly after SCI. In parallel, novel appearance of a second, short form transcript, in addition to the normal long (L) isoform, occurs by 8 h of injury. Up-regulation of tTG message and activity following neural injury. with appearance of a truncated GTP-unregulated S form, may represent new approaches to drug targets in neurotrauma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2002.00850.x
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    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Downsizing Survival: The Experience of Work and Organizational Commitment (2003)
    Boston, USA and Oxford, UK : Blackwell Publishing Inc
    Sociological inquiry 73 (2003), S. 0 
    Details
    ISSN: 1475-682X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology
    Notes: Although downsizing has become a common feature of American workplaces, the existing literature has focused on the effects of how downsizing is conducted, rather than considering how downsizing affects the experience of work for downsizing survivors. Using data from the 1997 National Employee Survey and structural modeling techniques, this study compares downsizing survivors and workers unaffected by downsizing on a variety of sociodemographic indicators, job characteristics, and organizational environment measures in order to explain the lower levels of organizational commitment among survivors. The model in which downsizing survival was directly and indirectly associated with commitment was generally supported. Survivors reported less commitment than unaffected workers. In addition, downsizing survival was positively associated with job-related stress and negatively associated with perceived organizational support, which translated into survivors’ lower levels of commitment. This research suggests that organizations that downsize should consider ways to redesign work processes so as to reduce job-related stress and should engage in organizational practices that demonstrate organizational support for surviving employees.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1475-682X.00056
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    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Guidelines for mechanical lung function measurements in psychophysiology (2002)
    Oxford, UK : Blackwell Publishing
    Psychophysiology 39 (2002), S. 0 
    Details
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Studies in psychophysiology and behavioral medicine have uncovered associations among psychological processes, behavior, and lung function. However, methodological issues specific to the measurement of mechanical lung function have rarely been discussed. This report presents an overview of the physiology, techniques, and experimental methods of mechanical lung function measurements relevant to this research context. Techniques to measure lung volumes, airflow, airway resistance, respiratory resistance, and airflow perception are introduced and discussed. Confounding factors such as ventilation, medication, environmental factors, physical activity, and instructional and experimenter effects are outlined, and issues specific to children and clinical groups are discussed. Recommendations are presented to increase the degree of standardization in the research application and publication of mechanical lung function measurements in psychophysiology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1469-8986.3950546
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    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Comparison of finger plethysmograph to ECG in the measurement of heart rate variability (2002)
    Oxford, UK : Blackwell Publishing
    Psychophysiology 39 (2002), S. 0 
    Details
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Two experiments compared finger plethysmograph (FP) to electrocardiogram (ECG) in providing accurate heart periods for use in heart rate variability (HRV) calculations. In Experiment 1, simultaneous ECG and FP recordings were taken from 16 healthy subjects at rest. In Experiment 2, 10 additional healthy subjects were recorded at rest and during the Stroop Color-Word Test. In both studies, high correlations were found between FP-derived and ECG-derived band variance for high and low frequency HRV at rest. But, during the Stroop task, correlations were strongly diminished. In addition, under both conditions, HRV measures were significantly higher using the FP signal. Thus, FP may be adequate for determining HRV at rest, but, for experimental use, ECG may still be recommended. Nonetheless, further studies that include test–retest reliability assessment of both data collection techniques are warranted before a more certain determination can be made.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1469-8986.3920246
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    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Detection of known and novel genes encoding aromatic ring-hydroxylating dioxygenases in soils and in aromatic hydrocarbon-degrading bacteria (2002)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 216 (2002), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Primers were designed and successfully used to screen aromatic hydrocarbon-degrading bacteria for the presence of class II aromatic ring-hydroxylating dioxygenase (RHD) genes and to amplify novel RHD genes from DNA extracted from soil using the polymerase chain reaction. Two previously undiscovered groups of genes encoding putative class II RHDs, designated the S and T clusters, were found in RHD different soil samples. Only one of 70 RHD gene fragments amplified from these soil samples could be assigned to a cluster of previously reported RHD genes. These results suggest that distinct and potentially numerically dominant groups of as-yet unrecognized aromatic hydrocarbon-degrading bacteria exist in soils.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.2002.tb11415.x
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    BOTTLENOSE DOLPHINS INCREASE BREATHING SYNCHRONY IN RESPONSE TO BOAT TRAFFIC (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Marine mammal science 19 (2003), S. 0 
    Details
    ISSN: 1748-7692
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: To minimize potential impacts of boat traffic on the behavior of cetaceans it is important to assess short-term behavioral responses to boats and interpret the long-term consequences of these. Anecdotal descriptions of synchronous behavior in cetaceans are particularly frequent with reports of individuals within schools surfacing to breathe in a coordinated fashion being common. However, quantitative descriptions are rare. This study begins by quantifying synchronous breathing patterns of bottlenose dolphins off northern Scotland. We investigate possible functions of synchrony such as feeding patterns and presence of calves. We then test whether the presence of boat traffic in an area used intensively by dolphins affects their breathing synchrony. Although the majority of dolphin schools observed showed random breathing patterns, 30.5 % of schools showed synchronous breathing. There was no variation in this behavior with respect to identifiable feeding activities. However, synchrony was significantly negatively telated to the presence of calves in the school (χ2= 7.17, df = 1, P = 0.007) and significantly positively related to the presence of boat traffic in the study area (χ= 13.85, df = 1, P = 0.0002). Such consistent short-term behavioral responses by dolphins may potentially accumulate to produce longer-term consequences both for individuals and the whole population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1748-7692.2003.tb01093.x
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    Paper (German National Licenses)
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