ISSN:
1542-474X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Background: Analysis of ventricular late potentials (LP) with signal-averaged ECG (SAECG) using three bipolar, orthogonal X,Y, Z leads is a validated method of risk-stratification in patients prone to ventricular tachycardia. The aim of-this study was to validate a ECG system, which allows LP analysis using X,Y, Z leads mathematically derived from the standard 12-lead ECG.Methods and Results: In 36 patients (age 56 ± 12 years, coronary artery disease 71 %, LVEF 46 ± 14%) with known or suspected ventricular tachyarrhythmia, two consecutive SAECGs were recorded, one with mathematically derived and another one with true X,Y, Z leads. Time domain measurements with these different lead systems were compared using linear regression analysis and “Bland-Altman” plots. Correlation was good (r = 0.92) for the filtered QRS complex duration, but poor for the terminal QRS amplitude (RMS) and duration (LAS) criteria (r = 0.66 and 0.61, respectively; P 〈 0.0001). Defining LPS as present if at least two of the three time domain criteria were abnormal, the result matched in 28 (78%), but differed in 8 (22%) patients.Conclusion: SAECG using X,Y, Z leads mathematically derived from the standard 12-lead ECG compared to true bipolar X,Y, Z leads show a close correlation in filtered QRS duration, but can differ considerably in the other time domain measurements, resulting in different interpretation of LP analysis in 22%. Therefore, SAECG registration should currently be performed with true X,Y, Z leads, until the accuracy of other approaches is validated. A.N.E. 2002;7(4):302–306
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1542-474X.2002.tb00178.x
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