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  • 2000-2004  (12)
  • 2002  (12)
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  • 2000-2004  (12)
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  • 1
    Electronic Resource
    Electronic Resource
    Ultrafast optical Kerr effect measurements of third-order nonlinearities in cross-conjugated iso-polydiacetylene oligomers (2002)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 116 (2002), S. 3834-3840 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We present a study on the ultrafast third-order nonlinearities of a novel series of iso-polydiacetylene oligomers (iso-PDAs). Unlike polydiacetylenes that contain a linearly-conjugated backbone, iso-PDAs have a backbone that is cross-conjugated. A new Kerr-gate technique, differential optical Kerr effect (DOKE) detection, is used to measure third-order nonlinear susceptibilities, χ(3), and second hyperpolarizabilities, γ, of monomer, dimer, trimer, pentamer, and heptamer samples in tetrahydrofuran (THF) solutions. A linear increase in γ as a function of the number of repeat units is observed for all samples except the monomer, suggesting that the fixed-length linearly conjugated segments dominate the electronic polarizability. An added increase to the oligomer nonlinearities due to communication along the cross-conjugated path is not observed. The largest nonlinearity was observed in the heptamer sample, displaying a second hyperpolarizability relative to the THF solvent of γheptamer/γTHF=181±9. In addition, an interesting feature arising out of the signal decay tail is present in the samples but absent in our THF solvent reference. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1447908
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  • 2
    Electronic Resource
    Electronic Resource
    Cardiac Stimulation Caused by Biogalvanic Current During Pacemaker Implantation (2002)
    Oxford, UK : Blackwell Futura Publishing, Inc.
    Pacing and clinical electrophysiology 25 (2002), S. 0 
    Details
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: VAN GELDER, B.M., et al.: Cardiac Stimulation Caused by Biogalvanic Current During Pacemaker Implantation. After lead positioning during implantation of a biventricular pacing system intermittent ventricular simulation was observed. There was no pacemaker connected to any of the leads, but ventricular capture could be provoked by an intermittent contact between the lead stylet, which was still partially inserted, and a self-retaining retractor. The same phenomenon was observed from the atrial lead.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9592.2002.00998.x
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  • 3
    Electronic Resource
    Electronic Resource
    LETTERS TO THE EDITOR (2002)
    Oxford, UK : Blackwell Futura Publishing, Inc.
    Pacing and clinical electrophysiology 25 (2002), S. 0 
    Details
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9592.2002.01794.x
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  • 4
    Electronic Resource
    Electronic Resource
    Acute and Subacute Toxicity Associated with Concurrent Adjuvant Radiation Therapy and Paclitaxel in Primary Breast Cancer Therapy (2002)
    Boston, MA, USA : Blackwell Science Inc
    The @breast journal 8 (2002), S. 0 
    Details
    ISSN: 1524-4741
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this study was to describe the toxicity of concurrent standard dose adjuvant radiation therapy (RT) and paclitaxel in a series of patients receiving primary breast cancer therapy. From June 1998 to April 1999, 20 patients with breast cancer received concurrent adjuvant radiation and paclitaxel. There were 16 patients (80%) with American Joint Committee on Cancer (AJCC) stage II disease and 4 with stage III disease. Eighteen patients, 12 postmastectomy and 6 breast conservation, were treated with definitive surgery followed by concurrent RT and paclitaxel. Two received concurrent neoadjuvant radiation and paclitaxel. All patients received a doxorubicin-containing combination prior to radiation and paclitaxel. RT was delivered concurrently with paclitaxel after the completion of all doxorubicin therapy, with all patients receiving at least two cycles of paclitaxel (175 mg/m 2) every 3 weeks during RT. Toxicity was graded weekly according to Radiation Therapy Oncology Group criteria. Thirteen patients (65%) developed grade 2 or higher cutaneous toxicity. In the postmastectomy group, 6 of 12 patients (50%) developed grade 2 cutaneous toxicity, and 4 of 12 patients (33%) developed grade 3. RT was discontinued in 1 and placed on hold in 3 of these patients. In the breast-conservation group, 2 of 6 patients (33%) developed grade 3 toxicity. In the neoadjuvant group, 1 of 2 patients (50%) developed grade 3 toxicity. Four patients (20%) developed radiation pneumonitis, 2 of 12 (17%) in the postmastectomy group and 2 of 6 (33%) in the breast conservation group, with 2 requiring hospitalization and 1 a diagnostic open-lung biopsy. In this group of patients, standard dose concurrent radiation and paclitaxel resulted in a high incidence of cutaneous and pulmonary toxicity. Concurrent radiation and paclitaxel with these doses and schedule should be approached cautiously until further studies documenting its safety are completed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1524-4741.2002.08306.x
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  • 5
    Electronic Resource
    Electronic Resource
    HAWAIIAN MONK SEALS (MONACHUS SCHAUINSLANDI) FORAGING IN DEEP-WATER CORAL BEDS (2002)
    Oxford, UK : Blackwell Publishing Ltd
    Marine mammal science 18 (2002), S. 0 
    Details
    ISSN: 1748-7692
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Plans to harvest deep-water corals in the remote Northwestern Hawaiian Islands, close to populations of endangered Hawaiian monk seals (Monachus schauinslandi), have raised concerns about the seals' use of deep-water habitats. Movements and diving patterns of seals studied at French Frigate Shoals (FFS) Atoll indicated two areas where five males out of 33 instrumented seals dove deep enough (300–500 m) to encounter commercially sought deep-water corals. Submarine surveys conducted at each location found beds of gold (Gerurdia sp.) and pink (Corallium sp.) precious coral suggesting an overlap between the foraging habitat of some seals and the target of the coral fishery. Areas adjacent to the coral beds that were visually censused using submersibles showed significantly fewer precious corals. Precious coral beds were not found on previous submarine surveys at other regions around FFS, supporting the notion that seals were selecting the areas with corals as forage habitat. Five male seals were fitted with back-mounted video cameras to document feeding among precious corals. None of the five seals dove deep enough to encounter precious corals (〉300 m). However, three of the seals visited beds of black coral (Cirrhipdhes sp.) at shallower depths (∼ 80 m). One seal was observed revisiting the black coral beds on three successive nights to feed on fish hiding among the coral stems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1748-7692.2002.tb01031.x
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  • 6
    Electronic Resource
    Electronic Resource
    Hospital Ownership Conversions: Defining the Appropriate Public Oversight Role (2002)
    Berkeley, Calif. : Berkeley Electronic Press (now: De Gruyter)
    Forum for health economics & policy 5 (2002), S. 6 
    Details
    ISSN: 1558-9544
    Source: Berkeley Electronic Press Academic Journals
    Topics: Medicine , Economics
    Notes: This paper reviews recent empirical evidence on the effects of hospital ownership conversions on quality of care and provision of public goods, such as uncompensated care, and presents new results on these topics based on hospital discharge data from the Healthcare Cost and Utilization Project's (HCUP) Nationwide Inpatient Sample. My analysis of these data reveals that conversion from government or private nonprofit to for-profit ownership has no effect on in-hospital mortality, but rates of pneumonia complications increased following conversion to for-profit status. Other research, discussed in the paper, found increased mortality rates following discharge from the hospital for patients admitted to hospitals that had converted to for-profit ownership. There was no effect of such conversions on the propensity to admit uninsured or Medicaid patients. Clearly, there is considerable heterogeneity in outcomes attributable to conversions. Overall, the evidence suggests a role for public scrutiny of hospital ownership conversions.
    Type of Medium: Electronic Resource
    URL: http://www.bepress.com/fhep/5/6
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  • 7
    Electronic Resource
    Electronic Resource
    Excess alcohol consumption and health outcomes: a 6-year follow-up of men over age 50 from the health and retirement study (2002)
    Oxford, UK : Blackwell Science Ltd.
    Addiction 97 (2002), S. 0 
    Details
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Aims This study examined the association of problem drinking history and alcohol consumption with the onset of several health conditions and death over a 6-year follow-up period.Setting We analyzed two waves of longitudinal data on men over 50 who participated in the Health and Retirement Study, a nationally representative sample of people aged 51–61 and their spouses living in the United States in 1992.Measurements Five types of health outcomes—mortality, general health, functional status, cognitive status, and mental health—were examined. Drinking categories were based on average drinks per day (0, 〈1, 1–2, 3–4, 5+), with 5 + defined as ‘very heavy drinking’. Problem drinking history was identified as 2+ affirmative responses to the CAGE questionnaire. We controlled for smoking and other factors at baseline.Findings Over the 6-year follow-up period, very heavy drinking at baseline quadrupled the risk of developing functional impairments (OR: 4.21 95% CI: 1.67, 10.61). A problem drinking history increased the onset of depression (OR: 1.67 95% CI: 1.02, 2.74), psychiatric problems (OR: 2.15 95% CI: 1.47, 3.13) and memory problems (OR: 1.71 95% CI: 1.14, 2.56). Heavy drinking among mature adults was not associated with increased incidence of other adverse health events (i.e. angina, cancer, congestive heart failure, diabetes, myocardial infraction, lung disease or stroke).Conclusion Very heavy drinking and a problem drinking history greatly increased rates of onset of functional impairments, psychiatric problems and memory loss in late middle age for men who had not experienced these impairments at their initial interview.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1360-0443.2002.00067.x
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  • 8
    Electronic Resource
    Electronic Resource
    Identification and analysis of the amylase-binding protein B (AbpB) and gene (abpB) from Streptococcus gordonii (2002)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 212 (2002), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The binding of salivary amylase to Streptococcus gordonii has previously been shown to involve a 20-kDa amylase-binding protein (AbpA). S. gordonii also releases an 82-kDa protein into the supernatant that binds amylase. To study this 82-kDa component, proteins were precipitated from bacterial culture supernatants by the addition of acetone or purified amylase. Precipitated proteins were separated by SDS–PAGE and transferred to a sequencing membrane. The P2 kDa band was then sequenced, yielding a 25 N-terminal amino acid sequence, CGFIFGRQLTADGSTMFGPTEDYP. Primers derived from this sequence were used in an inverse PCR strategy to clone the full-length gene from S. gordonii chromosomal DNA. An open reading frame of 1959 bp was noted that encoded a 652 amino acid protein having a predicted molecular mass of 80 kDa. The first 24 amino acid residues were consistent with a hydrophobic signal peptide, followed by a 25 amino acid N-terminal sequence that shared identity (24 of 25 residues) with the amino acid sequence of purified AbpB. The abpB gene from strains of S. gordonii was interrupted by allelic exchange with a 420-bp fragment of the abpB gene linked to an erythromycin cassette. The 82-kDa protein was not detected in supernatants from these mutants. These abpB mutants retained the ability to bind soluble amylase. Thus, AbpA, but not AbpB, appears sufficient to be the major receptor for amylase binding to the streptococcal surface. The role of AbpB in bacterial colonization remains to be elucidated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.2002.tb11259.x
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  • 9
    Electronic Resource
    Electronic Resource
    Beneficial bacteria of the periodontium (2002)
    Oxford, UK : Munksgaard International Publishers
    Periodontology 2000 30 (2002), S. 0 
    Details
    ISSN: 1600-0757
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0757.2002.03004.x
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  • 10
    Electronic Resource
    Electronic Resource
    Using geographical information systems for management of back-pain data (2002)
    Bingley : Emerald
    Journal of management in medicine 16 (2002), S. 219-237 
    Details
    ISSN: 0268-9235
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Medicine
    Notes: In the medical world, statistical visualisation has largely been confined to the realm of relatively simple geographical applications. This remains the case, even though hospitals have been collecting spatial data relating to patients. In particular, hospitals have a wealth of back pain information, which includes pain drawings, usually detailing the spatial distribution and type of pain suffered by back-pain patients. Proposes several technological solutions, which permit data within back-pain datasets to be digitally linked to the pain drawings in order to provide methods of computer-based data management and analysis. In particular, proposes the use of geographical information systems (GIS), up till now a tool used mainly in the geographic and cartographic domains, to provide novel and powerful ways of visualising and managing back-pain data. A comparative evaluation of the proposed solutions shows that, although adding complexity and cost, the GIS-based solution is the one most appropriate for visualisation and analysis of back-pain datasets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/02689230210434952
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