ISSN:
1365-2036
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
To test the impact of intravenous omeprazole on Helicobacter pylori eradication for bleeding peptic ulcers.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:A total of 175 H. pylori-infected patients with bleeding peptic ulcers were randomized into either an omeprazole group or a ranitidine group, receiving intravenous omeprazole or ranitidine for 3 days after endoscopy. Afterwards, 1-week triple therapy was used to eradicate H. pylori for both groups. Six weeks later, either a 13C-urea breath test or follow-up endoscopy was performed to assess the success of H. pylori eradication.〈section xml:id="abs1-3"〉〈title type="main"〉Results:The rebleeding rate was lower in the omeprazole group vs. the ranitidine group (6% vs. 17%, P 〈 0.05). The H. pylori eradication rate was higher in the omeprazole group (intention-to-treat analysis: 83% vs. 66%, P 〈 0.05; per protocol analysis: 93% vs. 80%, P 〈 0.05). For patients with duodenal ulcers, the per protocol H. pylori eradication rate of the omeprazole group was higher than that of the ranitidine group (93% vs. 73%, P 〈 0.05).〈section xml:id="abs1-4"〉〈title type="main"〉Conclusions:Intravenous omeprazole can decrease the risk of rebleeding of peptic ulcers. For duodenal ulcers, in particular, intravenous omeprazole may even improve the H. pylori eradication rate of the subsequent triple therapy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1046/j.1365-2036.2002.01137.x
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