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  • 2000-2004  (17)
  • 1970-1974
  • 1915-1919
  • 2003  (17)
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  • 2000-2004  (17)
  • 1970-1974
  • 1915-1919
Year
  • 1
    Electronic Resource
    Electronic Resource
    Evidence of oxidative stress in chronic venous ulcers (2003)
    Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 11 (2003), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Reactive oxygen species have been implicated in the impaired healing of chronic leg ulcers but little direct evidence is available. We have observed a significant (p 〈 0.01) elevation of the allantoin : uric acid percentage ratio, a marker of oxidative stress, in wound fluid from chronic leg ulcers (median 17, range 8–860) compared to both paired plasma (median 2, range 1–8) and acute surgical wound fluid (median 4, range 3–7). However, the allantoin : uric acid percentage ratio did not differ significantly between chronic wounds that healed and those that failed to heal. Neutrophil elastase was elevated 30- to 1300-fold in chronic wound fluid compared to plasma and there was a correlation (r 2 = 0.742) between wound fluid elastase and the allantoin : uric acid percentage ratio. Total antioxidant capacity of wound fluid, as measured with a chemiluminescence assay, did not show a correlation (r 2 = 0.03) with the observed oxidative stress. These observations suggest that conditions of localized oxidative stress, possibly related to neutrophil-associated production of reactive oxygen species, are present in chronic leg ulcers. It is possible that future therapeutic strategies aimed at reducing oxidative stress, in addition to good standard care, could improve healing rates of chronic wounds. (WOUND REP REG 2003;11:172–176)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1524-475X.2003.11304.x
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  • 2
    Electronic Resource
    Electronic Resource
    Clip Placement After Sonographically Guided Percutaneous Breast Biopsy (2003)
    Oxford, UK : Blackwell Science Inc
    The @breast journal 9 (2003), S. 0 
    Details
    ISSN: 1524-4741
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: A simple and inexpensive technique for deployment of a metallic marker at the site of an ultrasound guided core breast biopsy is described. An illustrative case in which this technique was employed to mark the location of three biopsied lesions is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1524-4741.2003.09319.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Development of the Cardiac Conduction System as Delineated by minK-lacZ (2003)
    350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Science Inc
    Journal of cardiovascular electrophysiology 14 (2003), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Introduction: Due to the lack of good molecular markers, for decades the morphogenetic origin of the cardiac conduction system has been a matter of debate. More recently, the spatial expression of minK-lacZ in the adult mouse heart has been shown, for the larger part, to be coincident with the conduction tissues. Methods and Results: To trace the embryonic development of this system, we performed an analysis of the expression of this construct throughout early cardiac development. Expression was first seen at the eighth embryonic day. Subsequently, discrete rings were found at the sinuatrial, atrioventricular, interventricular, and ventriculoarterial junctions. With time, the expression became restricted to boundary regions of the heart, such as the hinges of the leaflets of the pulmonary and aortic valves, the atrioventricular rings, and the venous valves, as well as becoming incorporated into the definitive conduction tissues themselves. In the postnatal heart, the areas retaining minK-lacZ positivity outside of the definitive conduction tissues are known to be the site of origin of abnormal cardiac rhythms, suggesting that ectopic foci may derive from tissues that share a common developmental pathway with the definitive conduction system. Conclusion: Our findings suggest that the boundary regions between compartments, along with the atrioventricular conduction axis, share a common developmental pathway. (J Cardiovasc Electrophysiol, Vol. 14, pp. 383-391, April 2003)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1540-8167.2003.02467.x
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  • 4
    Electronic Resource
    Electronic Resource
    Validating the Relationship Qualities of Influence and Persuasion With the Family Social Relations Model (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Human communication research 29 (2003), S. 0 
    Details
    ISSN: 1468-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Media Resources and Communication Sciences, Journalism
    Notes: Influence and persuasion are related, fundamental constructs in interpersonal communication. Both display the relationship qualities of interdependence, bidirectionality, reciprocity, and multiple levels of analysis. Yet, empirical validation of these relationship qualities is lacking, largely due to an absence of appropriate methods and statistical procedures. This article uses the family social relations model (SRM) to test for the personal relationship qualities of influence and persuasion in the family decision-making context of buying a new car. New relationship measures of influence and persuasion were developed because, historically, measures have been at the individual level. The sample size of 110 families proved sufficient for stable parameter estimates. The results uncovered patterns in the relationship qualities of influence and persuasion across 3 decisions families make when buying a new car (i.e., how much to spend, car model choice, final decision). The findings confirm that both influence and persuasion are truly relational. The novel use of the model across decisions allowed the patterns of relationships among family members to be compared, and demonstrated the importance of the relationship qualities of influence and persuasion in decision making. Predictions were examined across decisions as well so as to check the consistency of hypotheses. The results provide further insight into the meaning of influence and persuasion, and of SRM terms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-2958.2003.tb00832.x
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  • 5
    Electronic Resource
    Electronic Resource
    Purification and characterization of KpsT, the ATP-binding component of the ABC-capsule exporter of Escherichia coli K1 (2003)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 224 (2003), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The K1 capsule, an α(2,8)-linked polymer of sialic acid, is an important virulence determinant of invasive Escherichia coli. The 17-kb kps gene cluster of E. coli K1 encodes the information necessary for capsule expression at the cell surface. Two proteins, KpsM and KpsT, play a role in the transport of capsular polysaccharide across the cytoplasmic membrane, utilizing the energy from ATP hydrolysis. They belong to the ATP-binding cassette superfamily of transport proteins. In this study, we purified KpsT in its native form and show that the purified protein is able to bind ATP, undergo an ATP-dependent conformational change and hydrolyze ATP. Protease accessibility studies demonstrate the in vivo interaction between KpsM and KpsT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0378-1097(03)00428-2
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  • 6
    Electronic Resource
    Electronic Resource
    Acute increase in femoral artery resistance in response to direct physical stimuli in the human fetus (2003)
    Oxford, UK : Blackwell Science Ltd
    BJOG 110 (2003), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To determine whether fetal response to needling resembles the fetal ‘brain sparing’ response seen with hypoxaemia.Design Prospective observational study.Setting Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, London.Population Eighty-five pregnant women undergoing invasive procedures associated with fetal prenatal diagnosis and/or management.Methods The femoral artery and the middle cerebral artery pulsatility index were measured by Doppler ultrasonography before and after 89 invasive procedures (fetal blood sampling, transfusion, bladder or cyst aspiration, shunt insertion and amniocentesis, between 17 and 36 weeks). Cases in which the fetal body was transgressed were compared with ‘control’ fetuses undergoing invasive procedures which did not directly involve needling the fetus (amniocentesis and placental cord insertion procedures).Main outcome measures Femoral artery and middle cerebral artery pulsatility index.Results The femoral artery pulsatility index rose after transgression [median change (Δ) 0.73; 95% confidence interval (CI) 0.51 to 0.98]. In contrast, there was no significant change in femoral artery pulsatility index after non-transgression procedures (mean Δ 0.28; 95% CI −0.20 to 0.76). Analysis confirmed the fall in middle cerebral artery pulsatility index after transgression procedures (median Δ−0.19; 95% CI −0.07 to −0.35), but there was also a significant fall in middle cerebral artery pulsatility index after non-transgression procedures (mean Δ−0.47; 95% CI −0.23 to −0.71).Conclusions The human fetus mounts a peripheral haemodynamic response to invasive procedures involving transgression of the fetal body, which is consistent with the brain sparing effect. However, the change in middle cerebral artery pulsatility index in both transgression and control procedures suggests that the changes and mechanisms may be more complex than previously thought.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.2003.02373.x
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  • 7
    Electronic Resource
    Electronic Resource
    Buprenorphine versus methadone maintenance therapy: a randomized double-blind trial with 405 opioid-dependent patients (2003)
    Oxford, UK : Blackwell Science Ltd
    Addiction 98 (2003), S. 0 
    Details
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Aims  To assess the efficacy of buprenorphine compared with methadone maintenance therapy for opioid dependence in a large sample using a flexible dosing regime and the marketed buprenorphine tablet.Design  Patients were randomized to receive buprenorphine or methadone over a 13-week treatment period in a double-blind, double-dummy trial.Setting  Three methadone clinics in Australia.Participants  Four hundred and five opioid-dependent patients seeking treatment.Intervention  Patients received buprenorphine or methadone as indicated clinically using a flexible dosage regime. During weeks 1–6, patients were dosed daily. From weeks 7–13, buprenorphine patients received double their week 6 dose on alternate days.Measurements  Retention in treatment, and illicit opioid use as determined by urinalysis. Self-reported drug use, psychological functioning, HIV-risk behaviour, general health and subjective ratings were secondary outcomes.Findings  Intention-to-treat analyses revealed no significant difference in completion rates at 13 weeks. Methadone was superior to buprenorphine in time to termination over the 13-week period (Wald χ2 = 4.371, df = 1, P = 0.037), but not separately for the single-day or alternate-day dosing phases. There were no significant between-group differences in morphine-positive urines, or in self-reported heroin or other illicit drug use. The majority (85%) of the buprenorphine patients transferred to alternate-day dosing were maintained in alternate-day dosing.Conclusions  Buprenorphine did not differ from methadone in its ability to suppress heroin use, but retained approximately 10% fewer patients. This poorer retention was due possibly to too-slow induction onto buprenorphine. For the majority of patients, buprenorphine can be administered on alternate days.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1360-0443.2003.00335.x
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  • 8
    Electronic Resource
    Electronic Resource
    Methadone-related and heroin-related deaths among opiate users: methadone helps save lives (2003)
    Oxford, UK : Blackwell Science Ltd
    Addiction 98 (2003), S. 0 
    Details
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1360-0443.2003.00348.x
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  • 9
    Electronic Resource
    Electronic Resource
    The Geochemical Evolution of Riparian Ground Water in a Forested Piedmont Catchment (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Ground water 41 (2003), S. 0 
    Details
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: The principal weathering reactions and their rates in riparian ground water were determined at the Panola Mountain Research Watershed (PMRW) near Atlanta, Georgia. Concentrations of major solutes were measured in ground water samples from 19 shallow wells completed in the riparian (saprolite) aquifer and in one borehole completed in granite, and the apparent age of each sample was calculated from chloroflourocarbons and tritium/helium-3 data. Concentrations of SiO2, Na+, and Ca2+ generally increased downvalley and were highest in the borehole near the watershed outlet. Strong positive correlations were found between the concentrations of these solutes and the apparent age of ground water that was modern (zero to one year) in the headwaters, six to seven years midway down the valley, and 26 to 27 years in the borehole, located ∼500 m downstream from the headwaters. Mass-balance modeling of chemical evolution showed that the downstream changes in ground water chemistry could be largely explained by weathering of plagioclase to kaolinite, with possible contributions from weathering of K-feldspar, biotite, hornblende, and calcite. The in situ rates of weathering reactions were estimated by combining the ground water age dates with geochemical mass-balance modeling results. The weathering rate was highest for plagioclase (∼6.4 μmol/L/year), but could not be easily compared with most other published results for feldspar weathering at PMRW and elsewhere because the mineral-surface area to which ground water was exposed during geochemical evolution could not be estimated. However, a preliminary estimate of the mineral-surface area that would have contacted the ground water to provide the observed solute concentrations suggests that the plagioclase weathering rate calculated in this study is similar to the rate calculated in a previous study at PMRW, and three to four orders of magnitude slower than those published in previous laboratory studies of feldspar weathering. An accurate model of the geochemical evolution of riparian ground water is necessary to accurately model the geochemical evolution of stream water at PMRW.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-6584.2003.tb02434.x
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  • 10
    Electronic Resource
    Electronic Resource
    The ratio of non-fatal to fatal heroin overdose (2003)
    Oxford, UK : Blackwell Science Ltd
    Addiction 98 (2003), S. 0 
    Details
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1360-0443.2003.00474.x
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