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Digitale Medien

Vitamin E blocks early events induced by 1-methyl-4-phenylpyridinium (MPP+) in cerebellar granule cells (2003)

González-Polo, Rosa A. ; Soler, Germán ; Alvarez, Alberto ; [weitere]

Oxford, UK : Blackwell Science Ltd

Journal of neurochemistry 84 (2003), S. 0

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Details

ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Exposure of cerebellar granule cells (CGCs) to 1-methyl-4-phenylpyridinium (MPP+) results in apoptotic cell death, which is markedly attenuated by co-treatment of CGCs with the radical scavenger vitamin E. Analysis of free radical production and mitochondrial transmembrane potential (ΔΨm), using specific fluorescent probes, showed that MPP+ mediates early radical oxygen species (ROS) production without a loss of ΔΨm. Exposure to MPP+ also produces an early increase in Bad dephosphorylation and translocation of Bax to the mitochondria. These events are accompanied by cytochrome c release from mitochondria to cytosol, which is followed by caspase 3 activation. Exposure of the neurons to vitamin E maintains Bad phosphorylation and attenuates Bax translocation, inhibiting cytochrome c release and caspase activation. MPP+-mediated cytochrome c release is also prevented by allopurinol, suggesting the participation of xanthine oxidase in the process. Our results indicate that free radicals play an active role in the MPP+-induced early events that culminate with cell death.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1471-4159.2003.01520.x

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Digitale Medien

Prompt dipole γ-ray emission in fusionlike heavy-ion reactions (2003)

Pierroutsakou, D. ; Boiano, A. ; De Rosa, A. ; [weitere]

Springer

The European physical journal 17 (2003), S. 71-76

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ISSN: 1434-601X

Schlagwort(e): PACS. 25.70.-z Low and intermediate energy heavy-ion reactions – 24.30.Cz Giant resonances – 23.20.-g Electromagnetic transitions – 25.70.Gh Compound nucleus

Quelle: Springer Online Journal Archives 1860-2000

Thema: Physik

Notizen: Abstract: The 32S + 100Mo and 36S + 96Mo fusionlike reactions were studied at incident energy of E lab = 298 MeV and 320 MeV, respectively, with the aim of probing the influence of the entrance channel charge asymmetry on the dipole γ-ray emission. The excitation energy and spin distribution of the compound nucleus created in these reactions were identical, the only difference being associated with the unequal charge asymmetry of the two entrance channels. High-energy γ-rays were detected in an array of 9 seven-pack BaF2 clusters. Coincidence with fusionlike residues detected in four PPAC ensured the selection of central reaction events. By studying the differential γ-ray multiplicity associated with the two reactions it was shown that the dipole strength excited in the compound nucleus increases with the entrance channel charge asymmetry. From the linearized spectra, the increase of the GDR γ-ray intensity was found to be ∼ 25% for the more charge asymmetric system. The results are discussed and compared with those of previous data obtained at different incident energies.