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  • 2020-2023  (1)
  • 2005-2009  (63)
  • 1925-1929  (403)
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  • 1
    Electronic Resource
    Electronic Resource
    Cryocatheter Ablation of Right Ventricular Outflow Tract Tachycardia (2005)
    350 Main Street , Malden , MA 02148-5018 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Science Inc
    Journal of cardiovascular electrophysiology 16 (2005), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Introduction: Cryocatheter techniques have been successfully applied to treat supraventricular tachycardia but there are no reports on their value in treating ventricular tachycardia (VT). We present our initial experience with cryocatheter ablation of right ventricular outflow tract (RVOT) tachycardia. Methods and Results: Cryocatheter ablation was attempted in 14 patients (13 females, age 45.9 ± 12.7 years) who were highly symptomatic due to frequent monomorphic ventricular extrasystole (VES) or nonsustained VT originating within the RVOT. A 9-Fr, 8-mm-tip cryocatheter was used for both mapping and ablation. Cryoablation was started after localizing the arrhythmic focus by pace and activation mapping. Ablation success, defined by complete disappearance of target VES/VT acutely and during a follow-up of 9.3 ± 1.4 weeks, was achieved in 13 of 14 patients. Ablation was successful with local activation times of 35 ± 4 ms, 5.8 ± 3.3 applications, 18.8 ± 7.5 minutes total cryo time, 9.4 ± 4.2 minutes fluoroscopy time, and 66.9 ± 26.1 minutes total procedure time, the latter two measures showing a reduction with number of patients treated. Three patients reported slight pain related to local pressure of the catheter on the RVOT wall. No pain was described related to delivery of cryothermal energy. Conclusions: Initial experience shows that focal VES/VT originating in the RVOT can be successfully treated using cryocatheter ablation. Acute and short term success rates, fluoroscopy times, and duration of procedure are comparable to conventional ablation techniques. A major advantage seems to be the virtual absence of ablation related pain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1540-8167.2005.40571.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of Cardiac Resynchronization Therapy on Ventricular Repolarization in Patients with Congestive Heart Failure (2005)
    350 Main Street , Malden , MA 02148-5018 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Science Inc
    Journal of cardiovascular electrophysiology 16 (2005), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Introduction: Biventricular pacing has been shown to improve the clinical status of patients with congestive heart failure, but little is known about its influence on ventricular repolarization. The aim of our study was to evaluate the effect of biventricular pacing on ECG markers of ventricular repolarization in patients with congestive heart failure. Methods and Results: Twenty-five patients with congestive heart failure, sinus rhythm (SR), and complete LBBB (6 females; age 61 ± 8 years; NYHA class II–III; echocardiographic ejection fraction 21 ± 5%; QRS ≥ 130 ms) underwent permanent biventricular DDDR pacemaker implantation. A high-resolution 65-lead body-surface ECG recording was performed at baseline and during right-, left-, and biventricular pacing, and the total 65-lead root mean square curve of the QRST complex and the interlead QT dispersion were assessed. The QRS duration was increased during right (RV)- and left ventricular (LV) pacing (127 ± 26% and 117 ± 40%; P 〈 0.05), as compared to SR (100%) and biventricular pacing (93 ± 16%; ns). The QTc interval was increased during RV and LV pacing (112 ± 12% and 114 ± 14%; P 〈 0.05) as compared to SR (100%) or biventricular pacing (99 ± 12%). There was no effect on JT interval during all pacing modes. The Tpeak-end interval was increased during right (120 ± 34%; P 〈 0.01) and LV pacing (113 ± 29%; P 〈 0.05) but decreased during biventricular pacing (81 ± 19%; P 〈 0.01). A similar effect was found for the Tpeak-end integral and the Tpeak amplitude. QT dispersion was increased during right ventricular (129 ± 16 ms; P 〈 0.05) and decreased during biventricular pacing (90 ± 12 ms; P 〈 0.01), as compared to SR (114 ± 22 ms). Conclusions: Using a high-resolution surface ECG, biventricular pacing resulted in a significant reduction of ECG markers of ventricular dispersion of repolarization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1540-8167.2005.40496.x
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  • 3
    Electronic Resource
    Electronic Resource
    Magnetocardiography Predicts Coronary Artery Disease in Patients with Acute Chest Pain (2005)
    350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2XG , UK . : Blackwell Publishing, Inc.
    Annals of noninvasive electrocardiology 10 (2005), S. 0 
    Details
    ISSN: 1542-474X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: The value of magnetocardiography (MCG) for the detection of cardiac electrical disturbances associated with myocardial ischemia was studied. Methods: Sensitivity and predictivity of admission MCG for the presence of coronary artery disease (CAD) were prospectively evaluated in 264 consecutive patients presenting with acute chest pain and without ST-segment elevation. MCG findings were compared with 12-lead ECG, echocardiography (ECHO), and troponin-I in a head-to-head design. Coronary angiography was used for CAD diagnosis. Results: The visual assessment of magnetocardiograms by the experienced reader (R1) was superior to that by the unexperienced reader (R2) and superior to the automated computer analysis. Specificity and positive predictive value of MCG by R1 were comparable with those of ECG and troponin-I (〉90%), while ECHO specificity and ECHO positive predictive value were lower (76.2% and 87.9%, respectively). Sensitivity and negative predictive value of MCG were twice as high as those in the ECG, troponin-I, and ECHO tests. Conclusion: For the prediction of CAD in patients presenting with acute chest pain and without ST-segment elevation, an admission MCG test was superior to an admission ECG, ECHO, and troponin-I. The results of the study, however, are applicable only to a highly selected population comprising patients in whom immediate coronary angiography can be performed based on their clinical course in the hospital.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1542-474X.2005.00634.x
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  • 4
    Electronic Resource
    Electronic Resource
    THE SHADOW ECONOMIES OF THE ASIA-PACIFIC (2005)
    Melbourne, Australia : Blackwell Publishing Asia
    Pacific economic review 10 (2005), S. 0 
    Details
    ISSN: 1468-0106
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: Abstract.  Despite continuous government attempts to increase taxpayer compliance, the shadow economy continues to offer a way for taxpayers to evade their taxpaying obligations. The consequences are clear: policy-makers have increasingly imperfect knowledge about the state of economic affairs as shadow economy activity expands. We provide the first known estimates of the shadow economy for 17 Asia-Pacific countries. We show that, not only have these activities grown over the last ten years, but countries with relatively thin taxpayer compliance initiatives experience the greatest shadow economy activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-0106.2005.00280.x
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  • 5
    Electronic Resource
    Electronic Resource
    An Assessment of Environmentally- related Non-tariff Measures (2005)
    Oxford, UK : Blackwell Publishing Ltd
    The @world economy 28 (2005), S. 0 
    Details
    ISSN: 1467-9701
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Law , Economics
    Notes: International trade can affect the environment in different ways. This may justify the introduction of border measures by the importing countries. In addition to various dispositions in the GATT, GATS, TRIPs agreements, as well as in the Agreement on Agriculture, this issue is regulated by the agreements on Technical Barriers to Trade (TBT) and on the application of Sanitary and Phyto-sanitary standards (SPS). Despite these rules, abuse of environmental arguments for protectionist reasons remains an open issue. In order to disentangle protectionism from dispositions justified on the grounds of true environmental concerns, we systematically review notifications of SPS and TBTs by importing countries at the tariff line level. Trade is considered as being potentially affected when an environmental SPS/TBT is notified on grounds of environmental concerns. Affected trade is defined as imports by countries notifying such barriers. Protectionist use of environmental barriers is likely when only a limited number of countries impose an environmental obstacle on the imports of a given product. Considering data for 2001, we find that 88 per cent of the value of world trade is in products potentially affected by such measures, while 39 per cent of the value of world imports is potentially subject to a protectionist use of such measures. Agriculture, the automobile industry, the pharmaceutical industry and many other sectors are concerned.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-9701.2005.00742.x
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  • 6
    Electronic Resource
    Electronic Resource
    STRUCTURAL STUDIES BY ELECTRON TOMOGRAPHY: From Cells to Molecules (2005)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 74 (2005), S. 833-865 
    Details
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Notes: Electron tomography (ET) is uniquely suited to obtain three-dimensional reconstructions of pleomorphic structures, such as cells, organelles or supramolecular assemblies. Although the principles of ET have been known for decades, its use has gathered momentum only in recent years, thanks to technological advances and its combination with improved specimen preparation techniques. The rapid freezing/freeze-substitution preparation is applicable to whole cells and tissues, and it is the method of choice for ET investigations of cellular ultrastructure. The frozen-hydrated preparation provides the best possible structural preservation and allows the imaging of molecules, complexes, and supramolecular assemblies in their native state and their natural environment. Devoid of staining and chemical fixation artifacts, cryo-ET provides a faithful representation of both the surface and internal structure of molecules. In combination with advanced computational methods, such as molecular identification based on pattern recognition techniques, cryo-ET is currently the most promising approach to comprehensively map macromolecular architecture inside cellular tomograms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.biochem.73.011303.074112
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  • 7
    Electronic Resource
    Electronic Resource
    THE SYNTHESIS OF 1(9)-NITRO- AND 3(7)-NITRO-ACRIDINE AND 1(9)-METHYL- AND 3(7)-METHYLACRIDINE1 (1927)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 49 (1927), S. 1049-1052 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01403a025
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  • 8
    Electronic Resource
    Electronic Resource
    No significant effect of acute moderate alcohol intake on leptin levels in healthy male volunteers (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Addiction biology 10 (2005), S. 0 
    Details
    ISSN: 1369-1600
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: As, for ethical reasons, it is difficult to investigate by an experiment the effect of acute intoxication on leptin levels in alcoholics, we tested the hypothesis of lowered levels as an effect of acute ethanol intake in healthy volunteers. The subjects comprised (1) 17 healthy male participants, recruited via newspaper advertisements [age 29?3.75 years, body mass index (BMI) 24.3?3.5, leptin at baseline 3.3?3.1ng/ml]; (2) for comparison, leptin levels of 16 male alcoholic patients at day 1 of withdrawal were used. They were characterized as follows: (mean, median, standard deviation and range) age in years (41.1, 40.5, 10.2, 24, 57), BMI (23.3, 21.7, 5.4, 16.6, 37.5), 1032g of ethanol (median) consumed within the last 7 days, leptin levels 2.3mg/ml. A placebo-controlled double-blind trial was performed. Leptin levels of blood samples were taken at baseline (t1), before ethanol intake (t2), when blood alcohol had reached its maximum (t3) and the morning after (t4). The oral dose of ethanol administered was 0.6g/kg ethanol. (1) Volunteers: (a) the ethanol and placebo group exhibited leptin levels corresponding closely with levels measured at baseline (t1) (rs=0.85, p 〈0.0001) and follow-up (t4) (rs=0.768, p〈0.0001). (b) Leptin levels for the placebo and the alcohol-consuming (verum) group did not differ significantly at baseline, after ethanol intake or on the morning after [Mann-Whitney U-test (p=0.669, p=1.0 and p=0.887, respectively)]. (2) Leptin levels in relation to BMI did not significantly differ at any measurement time in either group. (3) Leptin levels/BMI of the healthy volunteers at t1 and t4 were not significantly different from those of 16 alcoholics. The data do not support the hypothesis of a significant effect of acute moderate alcohol intake on leptin levels in healthy volunteers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1080/13556210500313875
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  • 9
    Electronic Resource
    Electronic Resource
    Instructional/Developmental Communication: Current Theory, Research, and Future Trends (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of communication 55 (2005), S. 0 
    Details
    ISSN: 1460-2466
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Media Resources and Communication Sciences, Journalism
    Notes: The Instructional/Developmental Communication Division of ICA has produced a significant literature investigating communication processes within instructional settings as well as communication change occurring throughout the life span. This article documents the significant theoretical developments and empirical findings by communication scholars that have occurred over the past several decades. In addition, based upon the strengths and weaknesses of theory and research, it sets an agenda for future research within instructional/developmental research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-2466.2005.tb02686.x
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  • 10
    Electronic Resource
    Electronic Resource
    LexA regulates the bidirectional hydrogenase in the cyanobacterium Synechocystis sp. PCC 6803 as a transcription activator (2005)
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 58 (2005), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The bidirectional NiFe-hydrogenase of Synechocystis sp. PCC 6803 is encoded by five genes (hoxEFUYH) which are transcribed as one unit. The transcription of the hox-operon is regulated by a promoter situated upstream of hoxE. The transcription start point was located at −168 by 5′Race. Several promoter probe vectors carrying different promoter fragments revealed two regions to be essential for the promoter activity. One is situated in the untranslated 5′leader region and the other is found −569 to −690 nucleotides upstream of the ATG. The region further upstream was shown to bind a protein. Even though an imperfect NtcA binding site was identified, NtcA did not bind to this region. The protein binding to the DNA was purified and found to be LexA by MALDI-TOF. The complete LexA and its DNA binding domain were overexpressed in Escherichia coli. Both were able to bind to two sites in the examined region in band-shift-assays. Accordingly, the hydrogenase activity of a LexA-depleted mutant was reduced. This is the first report on LexA acting not as a repressor but as a transcriptional activator. Furthermore, LexA is the first transcription factor identified so far for the expression of bidirectional hydrogenases in cyanobacteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.2005.04867.x
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