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  • 1
    Electronic Resource
    Electronic Resource
    Aminoacyl transfer from an adenylate anhydride to polyribonucleotides (1975)
    Springer
    Journal of molecular evolution 6 (1975), S. 309-320 
    Details
    ISSN: 1432-1432
    Keywords: Aminoacyl Transfer ; Amino Acid Adenylate ; Imidazole Catalysis ; Evolution ; Peptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Imidazole catalysis of phenylalanyl transfer from phenylalanine adenylate anhydride to the hydroxyl groups of homopolyribonucleotides was investigated as a chemical model of the biochemical aminoacylation of tRNA. Imidazole catalyzed transfer of phenylalanine to poly (U) increases from pH 6.5 to 7.7 and decreases above pH 7.7. At pH 7.7 approximately 10% of the phenylalanyl residues are transferred to poly (U). At pH 7.1, transfer to poly (U) was five times as great as to poly (A) and transfer to a poly (A) poly (U) double helix was negligible. At pH 7.1 approximately 45 mole percent linkages to poly (U) were monomeric phenylalanine; the remainder of the linkages were peptides of phenylalanine. The number of linkages and their lability to base and neutral hydroxylamine indicates that phenylalanine and its peptides are attached as esters to the 2′ hydroxyl groups throughout poly (U) and the 2′ (3) hydroxyl groups at the terminus of poly (U). These results do model the contemporary process of aminoacyl transfer to tRNA and continue to suggest that a histidine residue is in the active site of aminoacyl-tRNA-synthetases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01794637
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Eye findings in the 13 trisomy syndrome (1977)
    Springer
    European journal of pediatrics 124 (1977), S. 179-183 
    Details
    ISSN: 1432-1076
    Keywords: 13-trisomy ; Microphthalmia ; Coloboma ciliary body ; Cataracts ; Retinal detachment ; Retinal dysplasia ; Proliferation of pigment epithelium ; Calcified drusen ; Fibrocartilaginous dysplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The gross and microscopic eye findings in the first historic case of the 13-trisomy syndrome included: severe microphthalmia, coloboma of the ciliary body, cataracts, detached retina, and retinal dysplasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00452109
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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