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  • 2010-2014  (1)
  • 2005-2009  (5)
  • 1880-1889  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Approximate solution for solute transport during spherical-flow push-pull tests (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Ground water 43 (2005), S. 0 
    Details
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: An approximate analytical solution to the advection-dispersion equation was derived to describe solute transport during spherical-flow conditions in single-well push-pull tests. The spherical-flow case may be applicable to aquifer tests conducted in packed intervals or partially penetrating wells. Using results of two-dimensional numerical simulations, we briefly illustrate the applicability of the derived spherical-flow solution and provide a comparison with its cylindrical-flow counterpart. Good agreement between simulated extraction-phase breakthrough curves and the spherical-flow solution was found when the length of the injection/extraction region was small compared to both aquifer thickness and maximum solute frontal position at the end of the injection phase. On the other hand, discrepancies between simulated breakthrough curves and the spherical-flow solution increased with increasing anisotropy in hydraulic conductivities. Several inherent limitations embedded in its derivation such as assumptions of isotropy and homogeneity warrant the cautious use of the spherical-flow solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-6584.2005.0002.x
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Time course of antibody response to recombinant Aspergillus fumigatus antigens in cystic fibrosis with and without ABPA (2005)
    Oxford, UK : Munksgaard International Publishers
    Pediatric allergy and immunology 16 (2005), S. 0 
    Details
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We determined follow-up levels of specific serum IgE to the recombinant Aspergillus fumigatus (A. fumigatus) allergens rAsp f 1, 3, 4 and 6 in patients suffering from cystic fibrosis (CF) with and without allergic bronchopulmonary aspergillosis (ABPA). Over a 32-month period follow-up data of 74 patients were collected. According to serology, 11 CF patients were not sensitized (CF controls), 40 were sensitized to A. fumigatus (Asp. f-sens.) and 23 patients fulfilled the serologic criteria for ABPA. Of these 23 ABPA patients 11 expressed the full clinical ABPA picture (classicABPA) and 12 failed to show sufficient relevant clinical signs (seroABPA), despite positive serology. The 23 ABPA patients had 16–18 times higher serum levels of specific IgE to rAsp f 4 and/or rAsp f 6 than those of Asp. f-sens. patients (rAsp f 4: 31.3 ± 45 EU/ml vs. 1.9 ± 2.2 EU/ml and rAsp f 6: 39.0 ± 44.3 EU/ml vs 2.1 ± 1.7 EU/ml). The combination of increased total serum IgE (〉1000 IU/l) and increased specific IgE to rAsp f 4 and/or rAsp f 6 allowed to diagnose classicABPA with 100% specificity and 64% sensitivity and with a high predicted positive (100%) and a high predicted negative (94%) value. During a combined treatment (seven patients) with oral corticosteroid and itraconazole, itraconazole alone (two patients) or neither oral corticosteroid nor itraconazole therapy (two patients) total serum IgE and specific IgE to rAsp f 4 and/or rAsp f 6 did decrease but did not normalize. Over the observation period, lung function remained unchanged, independent of whether oral steroids and/or concomitant itraconazole were either given or not given. In the follow-up of CF patients with ABPA under therapy the determination of total or specific IgE serum levels were of limited value to guide therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1399-3038.2005.00262.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia (2005)
    [s.l.] : Nature Publishing Group
    Nature genetics 37 (2005), S. 435-440 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Sickle cell anemia (SCA) is a paradigmatic single gene disorder caused by homozygosity with respect to a unique mutation at the β-globin locus. SCA is phenotypically complex, with different clinical courses ranging from early childhood mortality to a virtually unrecognized condition. Overt ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1533
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    Paper (German National Licenses)
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  • 4
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    Unknown
    Anti-Vaccinism (1882)
    Boston, Mass., etc. : Periodicals Archive Online (PAO)
    The North American Review. 134 (1882:Jan./June) 368 
    Details
    ISSN: 0029-2397
    Topics: English, American Studies , History
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:3197-1882-134-00-000025
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Field-scale isotopic labeling of phospholipid fatty acids from acetate-degrading sulfate-reducing bacteria (2005)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology ecology 51 (2005), S. 0 
    Details
    ISSN: 1574-6941
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Isotopic labeling of biomarker molecules is a technique applied to link microbial community structure with activity. Previously, we successfully labeled phospholipid fatty acids (PLFA) of suspended nitrate-reducing bacteria in an aquifer. However, the application of the method to low energy-yielding processes such as sulfate reduction, and extension of the analysis to attached communities remained to be studied. To test the feasibility of the latter application, an anoxic test solution of 500 l of groundwater with addition of 0.5 mM Br− as a conservative tracer, 1.1 mM SO2−4, and 2.0 mM [2-13C]acetate was injected in the transition zone of a petroleum hydrocarbon-contaminated aquifer where sulfate-reducing and methanogenic conditions prevailed. Thousand liters of test solution/groundwater mixture were extracted in a stepwise fashion after 2–46 h incubation. Computed apparent first-order rate coefficients were 0.31 ± 0.04 day−1 for acetate and 0.34 ± 0.05 day−1 for SO2−4 consumption. The δ13C increased from −71.03‰ to +3352.50‰ in CH4 and from −16.15‰ to +32.13‰ in dissolved inorganic carbon (DIC). A mass balance suggested that 43% of the acetate-derived 13C appeared in DIC and 57% appeared in CH4. Thus, acetate oxidation coupled to sulfate reduction and acetoclastic methanogenesis occurred simultaneously. The δ13C of PLFA increased on average by 27‰ in groundwater samples and 4‰ in sediment samples. Hence, both suspended and attached communities actively degraded acetate. The PLFA labeling patterns and fluorescent in situ hybridization (FISH) analyses of sediment and groundwater samples suggested that the main sulfate-reducing bacteria degrading the acetate were Desulfotomaculum acetoxidans and Desulfobacter sp. in groundwater, and D. acetoxidans in sediment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/j.femsec.2004.08.010
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    Paper (German National Licenses)
    Fulltext
  • 6
    Book
    Book
    Essential reproduction / (2007)
    Malden, Mass :Blackwell Pub,
    Details
    Title: Essential reproduction /
    Author: Johnson, Martin H.
    Edition: 6th ed
    Publisher: Malden, Mass :Blackwell Pub,
    Year of publication: 2007
    Pages: VIII, 316 S.
    ISBN: 978-1-405-11866-8
    Type of Medium: Book
    Language: English
    URL: lizenzfrei
    URL: lizenzfrei
    URL: lizenzfrei
    URL: 04
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    ZIB Catalog
    Zuse Institute Berlin get availability status
  • 7
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    Unknown
    Functional and Genomic Analyses of Alpha-Solenoid Proteins (2013)
    Details
    Publication Date: 2022-07-19
    Description: Alpha-solenoids are flexible protein structural domains formed by ensembles of alpha-helical repeats (Armadillo and HEAT repeats among others). While homology can be used to detect many of these repeats, some alpha-solenoids have very little sequence homology to proteins of known structure and we expect that many remain undetected. We previously developed a method for detection of alpha-helical repeats based on a neural network trained on a dataset of protein structures. Here we improved the detection algorithm and updated the training dataset using recently solved structures of alpha-solenoids. Unexpectedly, we identified occurrences of alpha-solenoids in solved protein structures that escaped attention, for example within the core of the catalytic subunit of PI3KC. Our results expand the current set of known alpha-solenoids. Application of our tool to the protein universe allowed us to detect their significant enrichment in proteins interacting with many proteins, confirming that alpha-solenoids are generally involved in protein-protein interactions. We then studied the taxonomic distribution of alpha-solenoids to discuss an evolutionary scenario for the emergence of this type of domain, speculating that alpha-solenoids have emerged in multiple taxa in independent events by convergent evolution. We observe a higher rate of alpha-solenoids in eukaryotic genomes and in some prokaryotic families, such as Cyanobacteria and Planctomycetes, which could be associated to increased cellular complexity. The method is available at http://cbdm.mdc-berlin.de/~ard2/.
    Language: English
    Type: article , doc-type:article
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    OPUS
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