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  • 2005-2009  (2)
  • 2000-2004  (3)
  • 1995-1999  (1)
  • 1
    Electronic Resource
    Electronic Resource
    003
Picroliv, a Phytochemical Enhances Wound Healing in Rats (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Tissue repair and wound healing are complex processes that involve inflammation, granulation, and tissue remodeling. Angiogenesis plays a central role in wound healing. Previously, we have shown that picroliv, a natural product obtained from the roots of Picrorhiza kurrooa upregulates the expression of vascular endothelial growth factor (VEGF) in human umbilical vein endothelial cells and insulin like growth factor (IGF) in rats during hypoxia (Cellular and Molecular Life Sciences 1999; 56: 348–55). In the present study, we have investigated the effect of Picroliv in an ex vivo rat aorta ring model of angiogenesis. Picroliv enhanced the sprouting and migration of endothelial cells. In this study, we have investigated the effect of picroliv in both unimpaired and dexamethasone (DX)-induced impaired cutaneous healing in a full thickness punch wound model in rats. The animals in the impaired healing group having been pretreated with DX. We studied the tissues by histology and morphometry. The data showed picroliv treatment resulted in improved reepithelialization, neovascularization, and migration of various cells such as endothelial, dermal myofibroblasts, and fibroblasts into the wound bed. Immunohistochemical localization showed an increased VEGF and alpha smooth muscle actin staining consistent with increased number of micro vessels in granulation tissue. These findings suggest that picroliv accelerated wound repair and thus could be developed as a therapeutic angiogenic agent for the wound healing.(This work was supported by a grant (5 R21 AT000517-02) from the NCCAM, National Institute of Health, Bethesda, MD.)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130215c.x
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  • 2
    Electronic Resource
    Electronic Resource
    119
Differential Regulation of Angiogenic Genes in Normal and Diabetic Wound Healing (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Wound healing is a complicated biological process that involves interactions of multiple cell types, various growth factors, their mediators and the extracellular matrix proteins. In this study, we have studied the differential regulation of angiogenic genes during wound healing in transgenic diabetic mice and non-diabetic mice. One 8 mm full thickness cutaneous wound under aseptic conditions was created on either side of the midline. Wound tissues were studied at 4, 7, and 11 days postwounding and healing was assessed by histology. The pathway specific gene expression profile of wound tissue in transgenic diabetic mice was compared with the normal mice. Profiling of these genes showed differential regulation of many angiogenic promoters, inhibitors, growth factors and cytokines. Furthermore, in our study hypoxia inducible factor (HIF-1a), osteopontin (OPN) and osteonectin are induced early at day 4, in both the diabetic and nondiabetic wound. The expression was downregulated by 11-day postwounding in the nondiabetic wound, whereas diabetic wounds showed constitutively high expression of these genes. The expression patterns of these genes were concomitant with the extent of healing as assessed by histology at different time point postwounding. These results suggest wound healing is a complex process that involves cascade of interaction of various factors. Although a single gene may not be solely responsible for any impairment in healing; however, an in-depth study of these genes and precise balance between the inducers and inhibitors of angiogenesis may provide an answer to the delayed healing in diabetic conditions.(This work was supported by a grant (5 R21 AT000517-02) from the NCCAM, National Institute of Health, Bethesda, MD.)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130216w.x
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  • 3
    Electronic Resource
    Electronic Resource
    CONTROL AND BIOCHEMICAL NATURE OF THE ECDYSTEROIDOGENIC PATHWAY (2002)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 47 (2002), S. 883-916 
    Details
    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract Molting is elicited by a critical titer of ecdysteroids that includes the principal molting hormone, 20-hydroxyecdysone (20E), and ecdysone (E), which is the precursor of 20E but also has morphogenetic roles of its own. The prothoracic glands are the predominate source of ecdysteroids, and the rate of synthesis of these polyhydroxylated sterols is critical for molting and metamorphosis. This review concerns three aspects of ecdysteroidogenesis: (a) how the brain neuropeptide prothoracicotropic hormone (PTTH) initiates a transductory cascade in cells of the prothoracic gland, which results in an increased rate of ecdysteroid biosynthesis (upregulation); (b) how the concentrations of 20E in the hemolymph feed back on the prothoracic gland to decrease rates of ecdysteroidogenesis (downregulation); and (c) how the prothoracic gland cells convert cholesterol to the precursor of E and then 20E, a series of reactions only now being understood because of the use of a combination of classical biochemistry and molecular genetics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ento.47.091201.145302
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  • 4
    Electronic Resource
    Electronic Resource
    QT Dispersion in 120 Electrocardiographic Leads in Patients with Structural Heart Disease (2002)
    Oxford, UK : Blackwell Futura Publishing, Inc.
    Pacing and clinical electrophysiology 25 (2002), S. 0 
    Details
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: STOVICEK, P., et al.: QT Dispersion in 120 Electrocardiographic Leads in Patients with Structural Heart Disease. The clinical significance of QT dispersion (QTd) measured in 12-lead ECGs is controversial. The aim of this study was to clarify factors that determine the QTd and its measurement errors in different lead arrays in patients with structural heart disease. Two blinded observers measured QT intervals on a computer screen from 120-channel ECG recordings in a retrospective set of 257 patients, comprising a group of 121 myocardial infarction (MI) survivors without ventricular tachyarrhythmia during a 6-month followup and a group of 136 survivors of ventricular tachyarrhythmia/fibrillation. QTd did not differ in patients with and without ventricular tachyarrhythmia/fibrillation. Eleven ventricular tachyarrhythmia/fibrillation survivors without structural heart disease had the lowest QTd (P ≤ 0.02). The strongest factor determining QTd and the magnitude of its measurement error was the lead array (P = 0.0001). Measurement errors had two components. The smallest relative errors were in the total body surface mapping array with one component related to interobserver reproducibility (9.1 ± 7.6%), and the other component related to accuracy of measurement of the QT interval (36 ± 16%). The authors estimated that a difference of QTd of at least 50 ms between study groups is required in a 12-lead ECG to draw any conclusions from the studies. In patients with structural heart disease, QTd from limited arrays of ECG leads was not a reliable measure. It correlated with the presence of structural heart disease, but not with arrhythmogenicity. An array consisting of ECG leads covering the entire chest allowed better reproducibility and measurement accuracy of QTd.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9592.2002.00020.x
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  • 5
    Electronic Resource
    Electronic Resource
    Understanding conceptual electronic design using protocol analysis (1998)
    Springer
    Research in engineering design 10 (1998), S. 129-140 
    Details
    ISSN: 1435-6066
    Keywords: Design process ; Design protocols ; Design research ; Function-behaviour-structure model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Notes: Abstract Many theories about the process, of design have been derived from prescriptive or descriptive analysis. There have been few attempts to empirically test these theories. Protocol analysis facilitates detailed inspection of the design process allowing design task analysis across the temporal dimension. Some hypotheses about the design process, derived from the literature, are objectively tested using results obtained from protocol analyses of various electronics designers engaged in conceptual design. Support for the hypotheses is found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01607155
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  • 6
    Electronic Resource
    Electronic Resource
    Comparing Alternative Methods of Measuring Geographic Access to Health Services (2000)
    Springer
    Health services and outcomes research methodology 1 (2000), S. 173-184 
    Details
    ISSN: 1572-9400
    Keywords: geographic access ; geographic information system ; travel time
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: This research compared alternative measures of geographic access to health care providers using different levels of spatial aggregation (county, zipcode and street) and different methods of calculating the cost of space (Euclidean distance, road distance and travel time). Data Sources: The research is based on a community-based sample of rural (74%) and urban (26%) Arkansans (n=435) and all medical providers (n=3,419) and mental health specialists (n=1,034) practicing in the state of Arkansas in 1993. Study Design: A cross-sectional study design was used to determine the availability of and accessibility to general medical and specialty mental health providers. Accessibility was defined as the travel time between each subject and the closest provider. Availability was defined as the number of providers within 30 minutes travel time of each subject. Data Collection: A Geographic Information System was used to geocode subjects and providers at the county, zip code and street levels, and to calculate the travel times, road distances and Euclidean distances between subjects and providers. Principal Findings: Regression results demonstrated that the most commonly used county-based measures of geographic access (e.g., MSA designation and providers per capita) explained 3%–10% of the variation in accessibility and 34%–70% of the variation in availability. Conclusions: Results indicate that Geographic Information Systems can be used to accurately measure geographic access to health services in a cost effective manner.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1012545106828
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