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  • 1
    Electronic Resource
    Electronic Resource
    Kynurenine Pathway Measurements in Huntington's Disease Striatum: Evidence for Reduced Formation of Kynurenic Acid (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 55 (1990), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Recent evidence suggests that there may be over-activation of the N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptors in Huntington's disease (HD). Tryptophan metabolism by the kynurenine pathway produces both quinolinic acid, an NMDA receptor agonist, and kynurenic acid, an NMDA receptor antagonist. In the present study, multiple components of the tyrosine and tryptophan metabolic pathways were quantified in postmortem putamen of 35 control and 30 HD patients, using HPLC with 16-sensor electrochemical detection. Consistent with previous reports in HD putamen, there were significant increases in 5-hydroxyindoleacetic acid, 5-hydroxytryptophan, and serotonin concentrations. Within the kynurenine pathway, the ratio of kynurenine to kynurenic acid was significantly (p 〈 0.01) increased twofold in HD patients as compared with controls, consistent with reduced formation of kynurenic acid in HD. CSF concentrations of kynurenic acid were significantly reduced in HD patients as compared with controls and patients with other neurologic diseases. Because kynurenic acid is an endogenous inhibitor of excitatory neurotransmission and can block excitotoxic degeneration in vivo, a relative deficiency of this compound could directly contribute to neuronal degeneration in HD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1990.tb03143.x
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  • 2
    Electronic Resource
    Electronic Resource
    Increasing sequence length favors .alpha.-helix over 310-helix in alanine-based peptides: Evidence for a length-dependent structural transition (1993)
    s.l. : American Chemical Society
    Biochemistry 32 (1993), S. 11957-11962 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00096a003
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Structural and magnetic properties of Ti/Co multilayers (1990)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 67 (1990), S. 4910-4912 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have investigated the structural and magnetic properties of sputter-deposited Ti/Co multilayer thin films. Sample composition was determined by Rutherford backscattering spectrometry. The crystal structure and composition modulation were examined with several x-ray diffraction techniques. X-ray diffraction analysis showed that the Ti and Co layers grow in the hcp structure and that the films are strongly textured along the (002) direction and are structurally incoherent. Composition modulation was confirmed from low-angle x-ray diffraction measurements. Vibrating-sample magnetometry (VSM) and Brillouin light scattering (BLS) were used to determine the magnetic properties of the films. VSM measurements of samples with Co layer thicknesses less than ≈22 A(ring) showed no measurable net magnetization, while those with greater Co layer thicknesses had both in-plane and perpendicular components. Using a simple model, the measured thickness dependence of the magnetization can be explained by assuming that 11.3 A(ring) of Co at each Ti interface is nonmagnetic with bulk magnetization for the remaining Co. Perpendicular volume and interface anisotropy constants obtained from the VSM data were Ks=0.23 erg/cm2 and Kv=3.5×106 erg/cm3, respectively. Excellent agreement was obtained between the best fit magnetic parameters for the VSM and the BLS data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.344728
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Varied line-space gratings and applications (invited) : Proceedings of the 4th international conference on synchrotron radiation instrumentation (1992)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 63 (1992), S. 1410-1414 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: This paper presents a straightforward analytical and numerical method for the design of a specific type of varied line-space grating system. The mathematical development will assume plane or nearly plane spherical gratings that are illuminated by convergent light, which covers many interesting cases for synchrotron radiation. The gratings discussed will have straight grooves whose spacing varies across the principal plane of the grating. Focal relationships and formulas for the optimal grating-pole-to-exit-slit distance and grating radius previously presented by other authors will be derived with a symbolic algebra system. It is intended to provide the optical designer with the tools necessary to design such a system properly. Finally, some possible advantages and disadvantages for application to synchrotron radiation beamlines will be discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1143030
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Synergistic response of plant hairy-root cultures to phosphate limitation and fungal elicitation (1991)
    s.l. : American Chemical Society
    Biotechnology progress 7 (1991), S. 434-438 
    Details
    ISSN: 1520-6033
    Source: ACS Legacy Archives
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bp00011a008
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  • 6
    Electronic Resource
    Electronic Resource
    Growth of plant root cultures in liquid- and gas dispersed reactor environments (1993)
    s.l. : American Chemical Society
    Biotechnology progress 9 (1993), S. 317-322 
    Details
    ISSN: 1520-6033
    Source: ACS Legacy Archives
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bp00021a011
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  • 7
    Electronic Resource
    Electronic Resource
    Use of Binding Measurements To Predict Elicitor Dosage Requirements for Secondary Metabolite Production from Root Cultures (1994)
    s.l. : American Chemical Society
    Biotechnology progress 10 (1994), S. 365-371 
    Details
    ISSN: 1520-6033
    Source: ACS Legacy Archives
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bp00028a004
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Determinants of Multifamily Mortgage Default (2002)
    Boston, USA and Oxford, UK : Blackwell Publishers Inc
    Real estate economics 30 (2002), S. 0 
    Details
    ISSN: 1540-6229
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: Option–based models of mortgage default posit that the central measure of default risk is the loan–to–value (LTV) ratio. We argue, however, that an unrecognized problem with extending the basic option model to existing multifamily and commercial mortgages is that key variables in the option model are endogenous to the loan origination and property sale process. This endogeneity implies, among other things, that no empirical relationship may be observed between default and LTV. Since lenders may require lower LTVs in order to mitigate risk, mortgages with low and moderate LTVs may be as likely to default as those with high LTVs. Mindful of this risk endogeneity and its empirical implications, we examine the default experience of 495 fixed–rate multifamily mortgage loans securitized by the Resolution Trust Corporation (RTC) and the Federal Deposit Insurance Corporation (FDIC) during the period 1991–1996. The extensive nature of the data supports multivariate analysis of default incidence in a number of respects not possible in previous studies. Consistent with our expectations, we find that LTV evidences no relationship to default incidence, while the strongest predictors of default are property characteristics, including three–digit ZIP code location and initial cash flow as reflected in the debt coverage ratio. The latter results are particularly interesting in that they dominated the influence of postorigination changes in the local economy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1080-8620.t01-1-00012
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  • 9
    Electronic Resource
    Electronic Resource
    Explaining Location Patterns of Suburban Offices (2003)
    Boston, USA and Oxford, UK : Blackwell Publishing Inc
    Real estate economics 31 (2003), S. 0 
    Details
    ISSN: 1540-6229
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: Suburban office markets exhibit a pattern of variegated clustering that is little explained by the conventional theories of urban form based on agglomeration effects and the cost of distance. To explain the pattern, this paper introduces industry economies of scale for “Class A” offices. Empirical tests for industry economies of scale are reported, based on data from the office market of Houston, Texas. The models presented, under conditions typical of North American cities in recent decades, imply the patterns of variegated clustering that are observed. They suggest a sequence of clusters, increasing in size and distance from the central business district. Further, they imply the potential for mass movement by tenants from older clusters to new.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1540-6229.00061
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Pricing Mortgage-Backed Securities: Integrating Optimal Call and Empirical Models of Prepayment (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Real estate economics 21 (1993), S. 0 
    Details
    ISSN: 1540-6229
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: Residential mortgage borrowers frequently appear to behave suboptimally with respect to their mortgage prepayment options. Many borrowers fail to exercise even well-into-the-money options while others prepay when the call option is out-of-the-money. To account for these apparently suboptimal prepayments, the recent trend in mortgage-backed securities research has been away from optimal call valuation models, in which the decision to exercise is determined endoge-nously, in favor of models in which prepayment behavior is exogenously specified based on empirical estimation. This paper develops a rational model of mortgage prepayment which incorporates both types of “non-optimal” prepayment and retains endogenous call. This enables the model to disentangle and compare the separate effects of the interest rate call, impeded by transaction costs, and of non-interest-rate driven prepayment. In addition, by recognizing heterogenous borrower transaction costs, the model presents a way to account more precisely for the varying prepayment lags associated with well-into-the-money call options and to account for the phenomenon of “burnout” within a mortgage pool. The paper includes an empirical test of the unbiasedness of the integrated pricing model by comparing simulated prices from our theoretical model to observed prices on traded Fannie Mae and GNMA securities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1540-6229.00617
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