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  • 1
    Electronic Resource
    Electronic Resource
    Demographic Analysis of a Disjunct Population of Froelichia floridana in the mid-Ohio River Valley (2002)
    Boston, MA, USA : Blackwell Science Inc
    Restoration ecology 10 (2002), S. 0 
    Details
    ISSN: 1526-100X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Froelichia floridana (cottonweed) occurs as a disjunct population along the Ohio River in southeastern Ohio. The anomalous occurrence of F. floridana in this area has led to its designation as a state endangered species and a management regime to maintain the habitat conditions in which it occurs. As part of this effort, a restoration site was established on public lands in 1984 from seed collected in areas threatened by development. This study seeks to determine the demographic characteristics of this species in the restored and non-restored managed sites to provide basic ecological information regarding life history parameters and to judge the effectiveness of the restoration. For two years (1997–1998) we collected information on seed bank abundance, field seed germination, plant survivorship, and seed production to create a stage-based transition matrix model. The model suggests that population growth and abundance as assayed by λ (rate of increase) are stable to declining and are similar between the restoration and natural sites. A reduction in competition had a positive effect on population growth. Elasticity analysis showed that plants germinating earlier in the spring and becoming established as an early cohort contributed a greater level of reproductive output than plants germinating in late spring. Lowered population growth for 1997 is attributed to a cooler and dryer than average early spring that delayed germination and subsequent seed production. Elasticity analysis also suggested that the presence of a persistent seed bank was crucial for long-term population maintenance and may allow for recovery in areas of low aboveground abundance through soil manipulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1526-100X.2002.02021.x
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  • 2
    Electronic Resource
    Electronic Resource
    Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Activated protein C (APC) is a serine protease that plays a central role in physiological anticoagulation, and has more recently been shown to be a potent anti-inflammatory mediator. Using cultured human cells, we show here that APC up-regulates the angiogenic promoters matrix metalloproteinase-2 in skin fibroblasts and umbilical vein endothelial cells, vascular endothelial growth factor in keratinocytes and fibroblasts, and monocyte chemoattractant protein-1 in fibroblasts. In the chick embryo chorioallantoic membrane assay, APC promoted the granulation/remodeling phases of wound healing by markedly stimulating angiogenesis as well as promoting reepithelialization. In a full-thickness rat skin-healing model, a single topical application of APC enhanced wound healing compared to saline control. APC-treated wounds had markedly more blood vessels on day 7 and a significantly lower infiltration of neutrophils at days 4 and 7. The broad spectrum matrix metallo-proteinas, GM6001, prevented the ability of APC to promote wound healing. In summary, our results show that APC promotes cutaneous wound healing via a complex mechanism involving stimulation of angiogenesis and inhibition of inflammation. These unique properties of APC make it an attractive therapeutic agent to promote the healing of chronic wounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.00130311.x
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  • 3
    Electronic Resource
    Electronic Resource
    Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain (2002)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 82 (2002), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Relaxin is a peptide hormone with known actions associated with female reproductive physiology, but it has also been identified in the brain. Only one relaxin gene had been characterized in rodents until recently when a novel human relaxin gene, human gene-3 (H3) and its mouse equivalent (M3) were identified. The current study reports the identification of a rat homologue, rat gene-3 (R3) relaxin that is highly expressed in a discrete region of the adult brain. The full R3 relaxin cDNA was generated using RT-PCR and 3′ and 5′ RACE protocols. The derived amino acid sequence of R3 relaxin retains all the characteristic features of a relaxin peptide and has a high degree of homology with H3 and M3 relaxin. The distribution of R3 relaxin mRNA in adult rat brain was determined and highly abundant expression was only detected in neurons of the ventromedial dorsal tegmental nucleus (vmDTg) in the pons, whereas all other brain areas were unlabelled or contained much lower mRNA levels. Relaxin binding sites and relaxin immunoreactivity were also detected in the vmDTg. These together with earlier findings provide strong evidence for a role(s) for multiple relaxin peptides as neurotransmitters and/or modulators in the rat CNS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2002.01114.x
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  • 4
    Electronic Resource
    Electronic Resource
    Replacement of Hydrogen at a Tertiary Carbon Atom with OH by Alkaline Permanganate1 (1960)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 82 (1960), S. 4249-4252 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01501a033
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  • 5
    Electronic Resource
    Electronic Resource
    Characterization of Triphenyltin Hydroxide and Bis-(triphenyltin) Oxide (1963)
    s.l. : American Chemical Society
    Inorganic chemistry 2 (1963), S. 187-189 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic50005a047
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  • 6
    Electronic Resource
    Electronic Resource
    A CRITIQUE OF ACCIDENT RESEARCH (1963)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 107 (1963), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1963.tb13312.x
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  • 7
    Electronic Resource
    Electronic Resource
    Combating Conflicting Messages of Values: A Closer Look at Parental Strategies (2005)
    Oxford, UK : Blackwell Publishing Ltd.
    Social development 14 (2005), S. 0 
    Details
    ISSN: 1467-9507
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Psychology
    Notes: This study examined how parents respond when their children encounter values outside the home that conflict with family values. Forty-eight middle-class European American parents completed questionnaires consisting of 11 vignettes asking how they would respond to hypothetical situations where outside sources posed potential conflicts with parental values to their adolescent child (M age of child=13.33 years). We identified five strategies that parents might use: controlled cocooning, reasoned cocooning, compromise, pre-arming, and deference. Parents in the study enlisted all five strategies, with reasoned cocooning and pre-arming occurring most frequently. The self-reported importance of values to parents was the most important predictor of which strategy parents used, with parents using more controlling strategies to defend values that were most important to them. Importance of values also mediated the relation between religion and the parent's self-reported desire for the child's compliance on personal issues, and parental strategy choice. This study is among the first to examine alternative parental strategies for regulating children's values acquisition outside the home, and shows that the extent of parental control is related to the importance of specific values to the parent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-9507.2005.00303.x
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  • 8
    Electronic Resource
    Electronic Resource
    The Partial Hydrolysis of Dialkyltin Dihalides (1961)
    s.l. : American Chemical Society
    The @journal of organic chemistry 26 (1961), S. 2304-2306 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo01351a037
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  • 9
    Electronic Resource
    Electronic Resource
    Woodrow Wilson, World War I, and American National Security (2001)
    Boston, USA and Oxford, UK : Blackwell Publishers Inc.
    Diplomatic history 25 (2001), S. 0 
    Details
    ISSN: 1467-7709
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: History , Political Science
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/0145-2096.00247
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  • 10
    Electronic Resource
    Electronic Resource
    PREDICTING HUMAN DRUG GLUCURONIDATION PARAMETERS: Application of In Vitro and In Silico Modeling Approaches (2004)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 44 (2004), S. 1-25 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Notes: Cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT), which both exist as enzyme "superfamilies," are together responsible for the metabolism of most hepatically cleared drugs. There is currently intense interest in the development of techniques that permit identification of the CYP and UGT isoform(s) involved in the metabolism of a newly discovered drug, and hence prediction of factors likely to alter elimination in vivo. In addition, the quantitative scaling of kinetic parameters for a metabolic pathway assumes importance for identifying newly discovered drugs with undesirable in vivo pharmacokinetic properties. Although qualitative and quantitative in vitro-in vivo correlation based on data generated using human liver tissue or recombinant enzymes have been applied successfully to many drugs eliminated by CYP, these strategies have proved less definitive for glucuronidated compounds. Computational (in silico) modeling techniques that potentially provide a facile and economic alternative to the in vitro methods are now emerging. This review assesses the utility of in vitro and in silico approaches for the qualitative and quantitative prediction of drug glucuronidation parameters and the challenges facing the development of generalizable models.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pharmtox.44.101802.121546
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