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  • 2005-2009
  • 2000-2004  (3)
  • Antiphospholipid antibody  (1)
  • Key words Cell motility  (1)
  • Key words Homeobox  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Pharbitis class-1 knotted-like homeobox gene, PKn3, shares similar characteristics to those of class-2 knotted-like genes (2000)
    Springer
    Plant cell reports 19 (2000), S. 911-920 
    Details
    ISSN: 1432-203X
    Keywords: Key words Homeobox ; Knotted ; Pharbitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Three novel homeobox genes, PKn1–3 (Pharbitis knotted-like), were isolated from Japanese morning glory (Pharbitis nil Chois, strain Violet). A sequence analysis showed that these genes belong to the knotted class-1 gene family and that PKn3 has a relatively unique sequence. All PKn genes are expressed in shoot apices, stems and roots, but not in cotyledons. Transformed tobacco with PKn1 or PKn2 displayed leaf shrinkage and a dwarf phenotype, while the ectopic expression of PKn3 gave no altered phenotypes. In situ hybridization showed that PKn3 is up-regulated in developing leaf primordia and that this expression becomes restricted in the basal region of young leaf blades, which is reminiscent of the expression pattern of the class-2 knotted gene, NTH23. These data suggest that these Pharbitis homeobox genes participate in the differentiation in shoots and suggest a unique function of PKn3 in developing leaves.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002990000214
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Thrombotic microangiopathic hemolytic anemia in systemic lupus erythematosus associated with antiphospholipid antibodies: usefulness of monitoring coagulation–fibrinolysis markers (2000)
    Springer
    Modern rheumatology 10 (2000), S. 260-262 
    Details
    ISSN: 1439-7609
    Keywords: Key words Hemolytic anemia ; Systemic lupus erythematosus ; Antiphospholipid antibody ; Plasma exchange ; Molecular markers for coagulation and fibrinolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report on a 24-year-old woman with systemic lupus erythematosus and lupus anticoagulant who developed chronic thrombotic microangiopathic hemolytic anemia. The patient responded well to a combination of plasma exchange and anticoagulant therapy. Changes in the molecular markers for coagulation and fibrinolysis corresponded with the disease activity. We suggest that thrombotic microangiopathic hemolytic anemia should be suspected when anemia and thrombocytopenia of unknown etiologies occur in systemic lupus erythematosus. In such cases, the evaluation of molecular markers for coagulation and fibrinolysis might be helpful both for diagnosis and for assessing the response to therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00012174
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Sequence analysis, gene expression, and chromosomal assignment of mouse Borg4 gene and its human orthologue (2000)
    Springer
    Journal of human genetics 45 (2000), S. 374-377 
    Details
    ISSN: 1435-232X
    Keywords: Key words Cell motility ; Binder of Rho GTPase ; CDC42 TC10 ; Borg4 ; Full-length cDNA ; Fluorescence in situ hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The Borg (binder of Rho GTPases) family proteins interact with CDC42 and TC10 in a guanosine triphosphate (GTP)-dependent manner. We have isolated a full-length cDNA of the mouse Borg4 gene, which is a member of this family. Sequence analysis revealed that this gene encoded a putative 349-amino acid protein. By reverse transcription — coupled polymerase chain reaction (RT-PCR) analysis, we observed that Borg4 was expressed ubiquitously in adult tissues. Additionally, we determined the entire cDNA sequence of the putative human Borg4 orthologue. By fluorescence in situ hybridization, mouse Borg4 and the putative human orthologue have been assigned to mouse chromosome 11E and human chromosome 17q24–25, which has been described as syntenic to the mouse region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380070012
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    Paper (German National Licenses)
    Fulltext
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