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  • 2005-2009  (1)
  • 2000-2004  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 30 (2005), S. 0 
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 149 (2003), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: There is a wide variety of topical or surgical treatment options for molluscum contagiosum (MC). However, treatment in young or anxious children is difficult, time-consuming and often painful. We studied the topical efficacy and tolerance of imiquimod, a topical immune-response modifier, which stimulates the production of interferon-αand other cytokines in children with MC. In an open-label, follow-up trial, imiquimod 5% cream was applied three times a week for 16 weeks to 15 children aged 4–11 years with multiple MC. Nine of 13 children (69%) who completed treatment responded. Two patients (15%) showed a complete remission, and seven (54%) had a partial response, with a remarkable reduction of the MC lesions. Four children (31%) showed stable or progressive disease. In three children (23%) with partial remission, the number of mollusca were considerably reduced, thus avoiding surgical treatment. In general, the treatment was well-tolerated, without systemic side-effects. Local side-effects included erythema (85%), itching (75%), burning sensations (23%) and pain (11%). Three children (23%) discontinued treatment because of local side-effects. The results of this study suggest that imiquimod 5% cream is a useful new treatment option for MC in children, especially in severe cases. The dosing schedule and length of treatment requires further evaluation.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 51 (2000), S. 838-845 
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Penizillinallergie ; Diagnostik ; Spezifisches IgE ; Hauttest ; Nahrungsmittel ; Keywords Penicillin-allergy ; Diagnostic ; Specific IgE ; Skin tests ; Food additives
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background and Objective. Penicillin allergy is a common clinical problem. The distinction between penicillin and para-infectious exanthems is difficult. We investigated the reliability of the history, as well as the sensitivity and specificity of skin tests and specific IgE levels. Patients/Methods: 160 patients with a history of penicillin allergy were retrospectivly evaluated in the outpatient department of a dermatological clinic. Results: Nearly 50% were diagnosed as allergic to penicillin by detection of specific IgE or skin test. About 60% of the patients with immediate type reactions, and 72% with maculo-papular erythema showed positive reactions in skin tests. Significantly more patients were diagnosed as allergic to penicillin by intradermal testing than by prick testing (p〈0,05). The sensitivity of the specific IgE RAST was 17,9%; the specifity, 89,5%. For the prick test the sensitivity was 8,2%; the spe-cifity 90,8%. For the intradermal test the sensitivity was 26%; the specifity 69,7%. Conclusions: We suggest a step by step procedure to detect penicillin allergy making the diagnostic results as valid as possible.
    Notes: Zusammenfassung Hintergrund und Fragestellung. Die Penizillinallergie (PA) ist ein häufiges klinisches Problem und ihre Abgrenzung zu parainfektiösen Exanthemen schwierig. Anhand unseres Patientengutes wurden die Wertigkeit der Anamnese und die Sensitivität und Spezifität von Hauttestung und spezifischem IgE untersucht. Patienten/Methodik: Daten zu 160 Patienten aus den Jahren 1993–1998 aus der Ambulanz einer Universitäts-Hautklinik mit anamnestischer Angabe einer PA wurden retrospektiv ausgewertet. Ergebnisse: Bei ca. 50% der Patienten wurde eine PA durch Bestimmung des spezifischen IgE oder durch Hauttestungen diagnostiziert. Von diesen zeigten ca. 60% mit einer Soforttypsymptomatik und 72% mit einem makulopapulösen Exanthem einen positiven Hauttest. Signifikant mehr Patienten reagierten in der Intrakutantestung als im Pricktest (p〈0,05). Die Sensitivität der Bestimmung des spezifischen IgE konnte mit 17,9%, die Spezifität mit 89,5% errechnet werden. Für den Pricktest betrug die Sensitivität 8,2%, die Spezifität 90,8%. Für den Intrakutantest wurde die Sensitivität mit 26% und die Spezifität mit 69,7% errechnet. Schlussfolgerungen: Wir schlagen eine stufenweise Abklärung bei PA vor, um die Aussage der Diagnostik möglichst sicher zu machen.
    Type of Medium: Electronic Resource
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