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  • 2005-2009
  • 1995-1999  (2)
  • 1965-1969
  • Asia  (1)
  • Calcium efflux  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 111 (1998), S. 278-280 
    ISSN: 1437-1596
    Keywords: Key words Sudden infant death syndrome (SIDS) ; Asia ; Japan ; Hong Kong ; United Kingdom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract The incidence of SIDS in western countries has decreased since the late 1980s after active SIDS prevention campaigns. By contrast, both Taiwan and Japan have reported an increase in incidences. In this report data from England, Wales, Scotland, Northern Ireland, Japan and Hong Kong are analysed. Regression coefficient and linearity of regression tests were used to determine if there was any significant increase or decrease in post-neonatal mortality (PNNM), SIDS mortality and mortality among infants 1–5 months old. A statistically significant decrease in SIDS was recognized in England, Wales, Scotland and Northern Ireland, whereas statistically significant increases were noted for Japan and Hong Kong. However in Japan and Hong Kong both the PNNM and mortality of infants between 1–5 months in age fell significantly, suggesting that the increased SIDS rates could be due to a change in diagnostic labelling. Further study will be required to determine whether this increase in the incidence of SIDS is genuine or only an artifact.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1437-7799
    Keywords: Key words SMP30 ; Calcium efflux ; Tubular epithelia ; Calcium pump ; Calmodulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. Senescence marker protein-30 (SMP30), a calcium binding protein, is preferentially expressed in the renal proximal tubules and hepatocytes and is presumed to play a role in Ca2+ homeostasis. Methods. To explore its physiological functions in the tubular cells, we investigated the effect of SMP30 on Ca2+ efflux via the ATP-dependent plasma membrane calcium pump. LLC-PK1 cells were stably transfected with a cDNA encoding SMP30, and the established transfectants were subjected to ATP responses. Results. Overexpression of SMP30 significantly increased Ca2+ efflux under both basal and ATP-stimulated conditions. Inhibition of calmodulin by trifluoperazine abrogated the enhanced Ca2+ efflux, suggesting that SMP30 activated the calmodulin-dependent Ca2+ pump. It is known that Ca2+ superfluous influx induces cellular injury. Compared with mock-transfected cells, LLC-PK1 cells expressing SMP30 showed resistance to cellular death triggered by Ca2+ superfluous influx. Conclusion. These results suggest the possibility that, in renal tubular cells, endogenous SMP30 participates in Ca2+ efflux via activating the calmodulin-dependent Ca2+ pump and thereby confers resistance of the cells against injury caused by high intracellular Ca2+ concentrations.
    Type of Medium: Electronic Resource
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