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  • 1
    Electronic Resource
    Electronic Resource
    The immune reaction to heterologous serum causes osteonecrosis in rabbits (1995)
    Springer
    Virchows Archiv 427 (1995), S. 205-211 
    Details
    ISSN: 1432-2307
    Keywords: Osteonecrosis ; Serum sickness ; Immune reaction ; Animal model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Osteonecrosis (ON) was produced experimentally in rabbits by intravenous injection of horse serum. Eighty adult rabbits were used: 16 were injected twice with isotonic saline (Group A), 24 were injected once with saline and once with horse serum (Group B), and 40 were injected twice with horse serum (Group C). Both femurs of each rabbit were obtained from 2 h to 7 weeks after the final injection an were subjected to histological examination. No pathological changes were seen in Groups A and B. In Group C, 5 of 15 rabbits (33%) showed ON (necrosis of trabecula and bone marrow) in the femoral metaphysis. In Group C, the early major pathological findings in bone marrow are extravasation of erythrocytes in sinusoidal spaces and microthrombi in small arteries and arterioles near the lesion of extravasation. Immune complexes were demonstrated in the kidney within 24 h of the final injection of horse serum. The present study suggests that immunological reaction associated with serum sickness may play an important role in inducible ON and this model will contribute toward clarifying the pathogenesis of ON.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00196527
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of calcium on flavanol production in cell suspension cultures of Polygonum hydropiper (1999)
    Springer
    Plant cell reports 18 (1999), S. 759-763 
    Details
    ISSN: 1432-203X
    Keywords: Key wordsPolygonum hydropiper ; Flavanol ; Procyanidin ; Cell suspension culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Cultured Polygonum hydropiper cells maintained in Murashige and Skoog (MS) medium supplemented with 10–6 m 2,4-D, 10–6 m kinetin, 0.1% casamino acids and 3% sucrose were transferred to medium containing a higher concentration of calcium chloride (15 mm). The content of flavanols in the cells on the 6th day was approximately twice that of the control culture (31.9–60.7 mg/g dry wt). However, the contents of other secondary metabolites such as chlorogenic acid and gallic acid were not changed. The levels of flavanols in the culture medium remained unchanged throughout the 21-day culture period. Of the the inorganic components supplemented to the culture medium , only elevated levels of calcium chloride induced an increase in flavanol contents of the cells. The results indicated that the elevated concentration of calcium in the culture medium played an important role in activating the accumulation of flavanols.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002990050656
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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