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  • 2005-2009  (3)
  • 1995-1999  (4)
  • 1
    Electronic Resource
    Electronic Resource
    A case of clear cell acanthoma presenting as nipple eczema (1999)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 141 (1999), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1999.03191.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Expression and prognostic implications of cell cycle regulatory molecules, p16, p21, p27, p14 and p53 in germinal centre and non-germinal centre B-like diffuse large B-cell lymphomas (2005)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 47 (2005), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims : To evaluate the different expression patterns and the prognostic significance of cell cycle regulatory molecules in diffuse large B-cell lymphomas (DLBCLs) of germinal centre (GC) and non-GC phenotypes.Methods and results : Tissue microarray slides composed of 126 extranodal and 88 nodal DLBCLs were immunostained for p16, p21, p27, p14 and p53. DLBCLs were classified into GC and non-GC phenotype according to the immunohistochemical expression of bcl-6, CD10, and MUM1. Aberrant expression of p53 was more frequent in the GC phenotype in nodal cases (P = 0.038), and the loss of p16, p21 and p14 expression was significantly more common in the non-GC phenotype (P = 0.004, P = 0.001, P 〈 0.001). Concurrent disruptions of the p16-Rb and p14-p53 pathways as represented by the immunoprofile of p16/p14/p53 (–/–/+) were associated with a poor prognosis in the GC phenotype [mean survival 31 months in the p16/p14/p53 (–/–/+) group versus 62 months in the other groups, P =0.0485].Conclusions : The expression and prognostic implications of cell cycle regulatory molecules differ between GC and non-GC phenotypes in DLBCLs. The immunoprofile of p16/p14/p53 (–/–/+) within the GC phenotype of DLBCLs can be defined as a poor prognostic subgroup.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2005.02222.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of salicylic–lactic acid conditioner on the shear bond strength of brackets and enamel surfaces (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of oral rehabilitation 32 (2005), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: summary  The purpose of this study was to evaluate the effects of salicylic–lactic (SL) acid conditioner on the shear bond strength of brackets. Fluoride releasing (Light-bond) and non-fluoride releasing (Enlight) composite adhesives were used after conditioning with 0·22% salicylic + 9% lactic acid or 34% phosphoric acid. Composite adhesives were light cured with either a halogen light curing (HLC) unit for 30–50 s or a plasma arc curing (PAC) unit for 4 s. The shear bond strength was measured with an Instron. Failure modes of debonded brackets were identified based on adhesive remnants on the bracket and tooth. Salicylic–lactic acid conditioning was found to provide adequate shear bond strength. Groups conditioned with SL acid were debonded mainly at the enamel–resin interface and comparatively clean enamel surface after debonding was observed than those conditioned with phosphoric acid. Using confocal laser scanning microscopic examinations, it was found that demineralization patterns between SL acid and phosphoric acid conditioned groups were not different when the same adhesive was used. The SL acid conditioner did not reduce the demineralization. Light-bond adhesive showed less demineralization than Enlight adhesive. The PAC unit can be recommended as an alterative to the HLC unit because it significantly reduces the irradiation time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.2004.01416.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Difference in the colour and colour change of dental resin composites by the background (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of oral rehabilitation 32 (2005), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: summary  The objective of this study was to evaluate the difference in the colour and colour change of dental resin composites over commonly used two backgrounds. Colour of five uncured and cured resin composites before and after polishing with 600-, 1000- or 1500-grit SiC paper was measured according to the CIELAB colour scale relative to the illuminant D65 over a white background (WB; reflectance = 91·57%) and a light trap (LT; reflectance = 0·01%) on a reflection spectrophotometer with the SCE geometry. Colour difference (ΔE*ab) by the background, and by the specimen conditions over each of two backgrounds was calculated. ΔE*ab values between the same specimen by the background were 2·38–11·60. ΔE*ab values by the specimen condition were varied by the background, and ΔE*ab between cured/polished specimens over WB were significantly higher than those over LT (P 〈 0·05) except a few cases. Background influenced three-colour coordinates of CIE L*, a*, and b* values differently depending on the material and the specimen condition. Background significantly influenced the colour coordinates and colour difference by the specimen conditions. As the light trap can eliminate the influence of variations at the background, measured colour over the light trap can be the colour of material itself. Correlation between the measured colour and varied shades of background should be further studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.2004.01402.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Epstein-Barr virus-associated lymphoproliferative eruption with progression to large granular lymphocytic leukaemia (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 137 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 12-year-old Korean girl gave a 9-year history of recurrent necrotizing papules and vesicles on the face, scalp and extremities. Skin biopsy specimens showed an atypical lymphoreticular infiltrate with vasculitis in the dermis and subcutis. In situ hybridization demonstrated latent infection by Epstein-Barr virus (EBV) of the lymphoid cells in the dermis. The disease was diagnosed as an EBV-associated lymphoproliferative skin eruption presenting as recurrent necrotic papulovesicles. The patient subsequently developed large granular lymphocytic leukaemia of natural killer cell origin. Our observations suggest that a patient with an EBV-associated lymphoproliferative skin eruption presenting with recurrent necrotic papulovesicles might progress to develop leukaemia as well as lymphoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1997.18631933.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Peripheral T-cell lymphoma involving subcutaneous tissue (1995)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 132 (1995), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The peripheral T-cell lymphomas, presumably derived from various immunocompetent peripheral T-cell system components, form a heterogeneous group of non-Hodgkin's lymphomas. We describe two patients with peripheral T-cell lymphoma primarily involving subcutaneous tissue. They presented with multiple subcutaneous nodules. Skin biopsy specimens in both patients demonstrated a lobular subcutaneous infiltrate. The infiltrate consisted of small and medium-sized atypical lymphoid cells. Both patients had a protracted clinical course before they were diagnosed as having malignant lymphoma. We detected latent Epstein-Barr virus infection in the skin lesions of case 2. Latent Epstein-Barr virus infection might be related to the development of this variant of peripheral T-cell lymphoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1995.tb05030.x
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Alteration of signal-transducing molecules in tumor-infiltrating lymphocytes and peripheral blood T lymphocytes from human colorectal carcinoma patients (1998)
    Springer
    Cancer immunology immunotherapy 45 (1998), S. 299-305 
    Details
    ISSN: 1432-0851
    Keywords: Key words TCR-CD3 ; TIL ; Colorectal cancer ; Protein tyrosine kinase (PTK) ; Immune suppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Tumor development or growth is accompanied by impaired immune responses, such as a poor proliferative response or down-regulated cytolytic T lymphocyte activity. Although recent reports have suggested that modification of the signal-transducing molecule is responsible for impaired immune responses in tumor-bearing hosts, the causes of defective immune function are not yet completely understood. Furthermore, the clinical significance of the findings is not yet clear. In this study, we investigated the alteration of several signal-transducing molecules in peripheral blood T lymphocytes (T-PBL) as well as in tumor-infiltrating lymphocytes (TIL) from human colorectal carcinoma patients and their relationship with the impaired host immune responses. A greater reduction in CD3ζ chain level was observed in TIL than in T-PBL from tumor-bearing hosts. CD3ζ chain reduction in T-PBL correlated with the clinicopathological stage of a tumor, especially with the status of lymph node metastasis. The levels of p56 lck and p59 fyn protein tyrosine kinase in T-PBL were also compared between tumor-bearing hosts and normal healthy volunteers. In T-PBL from tumor-bearing hosts, expression of protein tyrosine kinase p59 fyn was significantly lower than that of p56 lck . However, the level of CD3ζ chain expression did not correlate with T lymphocyte functions such as T lymphocyte proliferative response or allogeneic target cell lysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050446
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    Paper (German National Licenses)
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