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  • 2005-2009  (2)
  • 1995-1999  (4)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 65 (1995), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: We have reported previously that oxysterols inhibit astrogliosis and intracranial glioblastoma growth. To elucidate the mechanism of action of these molecules in vivo, we have investigated their effect on the cholesterol biosynthesis in the injured brain. In a bilateral lesion model, injection of liposomes containing 7β-hydroxycholesterol decreased [3H]acetate incorporation into neutral lipids and cholesterol by 30% and 40%, respectively. Structural analogues were tested using a unilateral lesion model. The injury did not significantly affect cholesterogenesis; injection of 7β-hydroxycholesterol or 7β-hydroxycholesteryl-3-oleate reduced acetate incorporation into cholesterol by 47% and 43%, respectively. Both 7-ketocholesteryl-3-oleate and 7α-hydroxycholesteryl-3-oleate inhibited cholesterogenesis by 32%. As cholesterol and by-products of the cholesterol pathway play a key role in cell division, we have assessed the effect of oxysterols on reactive astrocyte proliferation. The incorporation of bromodeoxyuridine showed that up to 46% of astrocytes were proliferating 24 h after the injury. Injection of 12 nmol of 7β-hydroxycholesterol or 7β-hydroxycholesteryl-3-oleate reduced the labelling index to 26%, whereas the labelling index in the 7-ketocholesteryl-3-oleate-treated cortex was 37%. These findings demonstrate that oxysterols are potent inhibitors of the endogenous cholesterol biosynthesis in brain and show a correlation between cholesterogenesis and reactive astrocyte proliferation.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 28 (1995), S. 174-179 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 436 (2005), S. 626-626 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sir Your News story “One in three scientists confesses to having sinned” (Nature 435, 718–719; 200510.1038/435718b) and the corresponding Commentary article, “Scientists behaving ...
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: A novel methodology which allows for fast and fully automatic structural analysis during preoperative planning for dental implant surgery is presented. This method integrates a fully automatic fast finite element solver within the framework of new concepts in computer-assisted preoperative planning for implant surgery. The planning system including optimized structural planning was validated by experimental results. Nine implants were placed in pig mandibles and mechanically loaded using a testing rig. The resulting displacements were measured and compared with those predicted by numerical analysis during planning. The results show that there were no statistically significant differences (P=0.65) between the results of the models and the experiments. The results show that fast structural analysis can be integrated with surgical planning software allowing the initial axial implant stability to be predicted in real time during planning. It is believed that such a system could be used to select patients for immediate implant loading and, when further developed, be useful in other areas of preoperative surgical planning.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 28 (1995), S. 417-422 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract The physiologic and clinicopathologic effects of weathered South Louisiana crude oil exposure were studied in the laboratory in juvenile loggerhead sea turtles. Sea turtles ingested oil incidentally, and oil was observed clinging to the nares, eyes, and upper esophagus, and was found in the feces. Oiled turtles had up to a four-fold increase in white blood cell counts, a 50% reduction in red blood cell counts, and red blood cell polychromasia. Most serum blood chemistries (e.g., BUN, protein) were within normal ranges, although glucose returned more slowly to baseline values than in the controls. Gross and histologic changes were present in the skin and mucosal surfaces of oiled turtles, including acute inflammatory cell infiltrates, dysplasia of epidermal epithelium, and a loss of cellular architectural organization of the skin layers. The cellular changes in the epidermis are of particular concern because they may increase susceptibility to infection. Although many of the observed physiological insults resolved within a 21-day recovery period, the long-term biological effects of oil on sea turtles remain completely unknown.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-2932
    Keywords: recovery ; acid lake ; smelter ; copper ; nickel ; sulphate ; Rhizosolenia ; Cosmarium ; Bosmina ; Chydorus ; Chaoborus ; rotifers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Studies are reported on two small lakes at Sudbury, Ontario located close to a nickel-copper smelter which closed in 1972. At that stage, Baby Lake had a pH of 4.0–4.2 while the adjacent Alice Lake had a pH 5.9–6.3. Both lakes were almost entirely devoid of algae and had neither Zooplankton nor fish. Soon after the closure of the smelter, with its large airborne volume of sulphur dioxide and of copper and nickel containing particulates, the chemistry of the lakes began to change. By 1985, Baby Lake had changed from pH 4.0 to 6.8 and is now at pH 7.2. The pH of Alice Lake increased from a low of 5.9 in the early 1970s to 6.9–7.4 in the mid 1980s and is now at 7.3. Copper and nickel concentrations also decreased in both lakes during this period. The first biota found in the lakes in the post-smelter stage in the early 1980s were benthic red chironomids, planktonic rotifers, and a limited number of phytoplankton species, of which Rhizosolenia was the most common. By the 1990s, 13 phytoplankton species were present in each lake, with a substantial Zooplankton fauna (14 species) of rotifers, copepods, and cladocerans. There are now numerous insect larvae in the sediment and some small fish in both lakes. The biological recovery, which followed substantial reductions in acidity and in soluble nickel and copper concentrations in the waters, is a slower process than chemical recovery and is initially characterized by the dominance of a few species.
    Type of Medium: Electronic Resource
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