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  • 1
    Electronic Resource
    Electronic Resource
    Fully automated solid phase synthesis of protected peptide hydrazides on recycling hydroxymethyl resin (1976)
    s.l. : American Chemical Society
    The @journal of organic chemistry 41 (1976), S. 3255-3258 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00882a009
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  • 2
    Electronic Resource
    Electronic Resource
    A SENSITIVE FLUOROMETRIC METHOD FOR THE ESTIMATION OF 3,4-DIHYDROXYPHENYLETHYLENE GLYCOL SULPHATE IN BRAIN TISSUE (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— A simple fluorometric method for the estimation of endogenous 3,4-dihydroxyphenylethylene glycol sulphate (DOPEG-SO4) in brain tissue is described. DOPEG-SO4 was extracted from brain tissue with 0.4 n-perchloric acid and purified by column chromatography on QAE-Sephadex A-25, Cl− form. The isolated DOPEG-SO4 was hydrolysed by incubation with a purified preparation of sulphatase from Helix pomatia. The free DOPEG thus formed was further purified on a column of aluminium oxide and determined fluorometrically after conversion to a fluorescent compound by condensation with ethylenediamine.The sensitivity of this method was about 15 ng per perchloric acid extract applied on the column (3 ml) and the reproducibility was excellent, with a variation coefficient of 1.6% (n = 5). The concentration of DOPEG-SO4 in whole brains of rats, determined by the present method, was 79.3 ± 4.7 ng/g (mean ± S.D., n = 10) in terms of free DOPEG. No appreciable DOPEG-SO, was detected in the brains of mice and guinea-pigs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb10488.x
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  • 3
    Electronic Resource
    Electronic Resource
    D2–40 Expression in Hemangiomas and Lymphangiomas: Special Reference to its Differential Utility Between Kaposiform Hemangioendothelioma and Acquired Tufted Angioma (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Journal of cutaneous pathology 32 (2005), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Recent investigations have demonstrated the utility of D2–40 as a marker for lymphatic endothelium and can be used for formalin-fixed and paraffin-embedded materials. We studied 13 capillary hemangiomas: kaposiform hemangioendothelioma (KH, 2), acquired tufted angioma (ATA, 5), juvenile hemangioma (JH, 2), granuloma pyogenicum (GP, 4); 6 other hemangiomas: cavernous hemangioma (3), arterio-venous hemangioma (1), angiokeratoma (1), epithelioid hemangioma (1); Kaposi’s sarcoma (1); 12 lymphangiomas: lymphangioma circumscriptum (6), deep type of cutaneous lymphangioma (6). D2–40 monoclonal antibody, endothelial markers (CD31, CD34, Factor VIII related antigen) and juvenile hemangioma-associated marker GLUT-1 were applied. D2–40 was immunopositive for the peripheral area of proliferative capillaries and negative for surrounding dilated vessels in KH, but positive for surrounding dilated vessels and negative for tufted proliferative capillaries in ATA. KH and ATA were all positive for endothelial markers and negative for GLUT-1. Other hemangiomas were negative for D2–40. Eight of 12 cases were positive for lymphangiomas. Based on these results, D2–40 is a useful additional immunostain for the discrimination of KH and ATA. KH and ATA may originate from different stage of both the lymphatic and blood vessel endothelial lineages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0303-6987.2005.0320l.x
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  • 4
    Electronic Resource
    Electronic Resource
    Lymphoepithelioma-Like Carcinoma of the Skin: A Case Report (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Journal of cutaneous pathology 32 (2005), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Lymphoepithelioma-like carcinoma of the skin is a rare tumor with a microscopic resemblance to lymphoepitheliomatous carcinoma of the nasopharynx. We present a 93-year-old man with papules on the left auricle to the cheek that were gradually enlarged. By the time of a biopsy, it grew to a 5.0 × 3.0 × 2.8 cm dark red mass, and necrotic debris was attached to the surface. Histologically, a relatively well-demarcated, dermal-hypodermic multiple lobules were composed of irregular islands of atypical epithelial cells. The uniform tumor cells had moderate amounts of lightly eosinophilic cytoplasm and vesicular nuclei with one or two prominent nucleoli. A dense lymphocytic infiltrate was present within the neoplastic islands, obscuring the epithelial component. The neoplastic cells were unconnected to the overlying epidermis. Neither squamous nor glandular differentiation was present. Immunohistochemically, the neoplastic cells were positive for epithelial membrane antigen and cytokeratin, and negative for latent membrane protein 1. No Epstein-Barr virus-encoded RNA (EBER) was detected by in situ hybridization. The negativity for Epstein-Barr virus may be a help in the differential diagnosis from metastatic undifferentiated nasopharyngeal carcinoma, which is uniformly positive for EBER.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0303-6987.2005.320ev.x
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  • 5
    Electronic Resource
    Electronic Resource
    Clinicopathological and Immunohistochemical Study of Eccrine Porocarcinoma (Malignant Eccrine Poroma) (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Journal of cutaneous pathology 32 (2005), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Porocarcinomas are thought to be differentiated into the acrosyringeal portion of the sweat duct, and they are relatively rare. It may develop from a long standing eccrine poroma undergoing malignant transformation or may arise de novo. We evaluated pathological and immunohistocheimical findings of six cases of eccrine porocarcinoma. Special stains (PAS and PAS with diastase) and immunohistochemical stainings (CEA, CAM5.2, CK7, bcl-2, p53 protein, and MIB-1) were performed. We observed asymmetrical architecture, cytological pleomorphism, prominent nucleoli, ductal differentiation, intracytoplasmic lumina, mitotic activity, and melanin colonization. Three patients were male and four patients were female. The average age was 76 years. The time interval from tumor onset to treatment ranged from 6 months to 10 years. The mean size was 3.2 cm, and the mean depth of invasion was 1.0 cm. Four tumors were found on the head, one on the hip, and one on the foot. Regional lymph node metastases were noted in one case. Microscopically, luminal spaces and intracytoplasmic lumina were noted in all cases. Immunohistochemically, the mean MIB-1 index was 41%. P53 immunoreactivity was detected in five cases. Interestingly, a case of porocarcinoma with lymph node metastases showed high mitotic figures as well as less lymphocytic infiltration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0303-6987.2005.320fb.x
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  • 6
    Electronic Resource
    Electronic Resource
    Human gnathostomiasis (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 18 (1991), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Two patients became infested with Gnathostoma nipponicum after eating raw loach-fish they had caught in a rice field in central Japan. A fragment of Gnathostoma was found in a biopsy from one of them. The sera of both patients reacted with Gnathostoma antigen using indirect immunofluorescence. Scanning electron microscopy was performed on blocks of the paraffin-embedded parasite sample and the viscera of a fish from the same rice field. The risk of eating raw freshwater fish is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1991.tb00137.x
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  • 7
    Electronic Resource
    Electronic Resource
    Chronology of Cellular Blue Nevus (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Journal of cutaneous pathology 32 (2005), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cellular blue nevus is composed of dendritic melanocytes, together with islands of epithelioid and plump spindle cells. We examined 58 cases of blue nevi. Fourteen cases were common blue nevi. The remaining 44 blue nevi were divided into three types according to its silhouettes. These were nodular (type 1, 18 cases), nodular with notch (type 2, 16 cases), and rounded pushing patterns (type 3, 10 cases). Well circumscribed top heavy nodule was observed in type 1, and it was limited to the dermis. Type 2 showed budding appearance into the subcutaneous tissue. Type 3 revealed bottom heavy with downward pushing margin. Both type 2 and type 3 were demonstrated biphasic patterns of epithelioid and spindle cells. Perineural distribution of melanocytes was also observed in type 2 and 3. The size of these types was 3.3 mm in type 1, 4.7 mm in type 2, and 7.4 mm in type 3. The thickness of these types was 1.6 mm in type 1, 2.5 mm in type 2, and 5.2 mm in type 3. Our results suggest that cellular blue nevi may be divided into three stages. Type 1 is its early stage, and may be misinterpreted as common blue nevi.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0303-6987.2005.320di.x
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  • 8
    Electronic Resource
    Electronic Resource
    Vesiculo-Bullous Dermatomyositis Associated with Malignant Lymphoma (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Journal of cutaneous pathology 32 (2005), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Dermatomyositis is an inflammatory condition of the skin and muscles, and an underlying malignancy is noted in 10% or more of cases. Clinical features of dermatomyositis include increasing general fatigue and proximal (thighs and shoulders) muscle weakness accompanied by erythematous lesions of the skin. There have been several distinct types of dermatomyositis described. Here we describe a case of vesiculo-bullous dermatomyositis, which is a rare variant of dermatomyositis. A 49-year-old woman was admitted to our hospital with a painful erythematous vesicular eruption of the face, trunk and extremities. In addition, edema of the face and fever were observed. Clinically, dermatomyositis was considered because of typical skin rashes (Gottron’s papules, periorbital heliotrope rash and poikiloderma) and serum creatine phosphokinase level of 1,031 IU/L. A skin biopsy was performed. Microscopically, subepidermal vesiculation with marked edema was present. Lymphoplasmacytic infiltration was also observed in the upper dermis. So far only a few case reports of vesiculo-bullous dermatomyositis have been reported in the literature. It should be kept in mind that dermatomyositis may present subepidermal vesiculation in order to avoid a misdiagnosis and unnecessary delayed treatment. Furthermore, an internal malignancy should be considered in such a variant of dermatomyositis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0303-6987.2005.320fa.x
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  • 9
    Electronic Resource
    Electronic Resource
    THE ROLE OF PRIOR AUSTENITE GRAINS IN FATIGUE CRACK INITIATION AND PROPAGATION IN LOW CARBON MARTENSITE (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 2 (1979), S. 0 
    Details
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract— A study has been made of the role of Prior Austenite Grains (PAG) in fatigue crack initiation and propagation in low carbon martensite.The occurrence of ferrite precipitation along prior austenite grain boundaries during rapid cooling will lead to the formation of intergranular cracking. This intergranular cracking has a close relationship with the reduction of the endurance limit for fine grained low carbon martensite.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-2695.1979.tb01083.x
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  • 10
    Electronic Resource
    Electronic Resource
    Distribution, excretion and biotransformation of 14C-piromidic acid in goldfish Carassius aumtus (L.) (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 2 (1979), S. 0 
    Details
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Abstract. The pharmacokinetic and metabolic disposition of piromidic acid (PA) was studied in goldfish orally administered a single dose of 40 mg/kg of PA or 14C-PA with the following results. PA was rapidly absorbed from the alimentary tract and became widely distributed to give maximal organ and tissue levels mostly after 1 h post dosing. Organ and tissue levels of PA as measured by the radioactivity were 1.4–2.2 times as high as those obtained by the bioassay, though their distribution patterns were similar. PA was partly biotransformed to unconjugated antibacterial metabolites, i.e., α-OHPA and β-OHPA and partly to more hydrophilic glucuronides which were excreted into bile. Bioactive metabolites along with PA disappeared almost entirely from the fish within 48 h post dosing. The antibacterial activity of α-OHPA and β-OHPA against major pathogenic bacteria isolated from fish showed two to four-fold greater activity as compared with PA. This pharmacokinetic and metabolic disposition, together with the antibacterial activity of PA and its active metabolites, suggest a possible practical application of PA against bacterial fish diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2761.1979.tb00414.x
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