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  • 2005-2009
  • 1985-1989  (2)
  • 1970-1974  (1)
  • Biochemistry and Biotechnology  (1)
  • Clinical Response  (1)
  • Colletotrichum lindemuthianum  (1)
Source
Material
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    The possible role of metabolites in therapeutic response to chlorpromazine treatment (1973)
    Springer
    Psychopharmacology 32 (1973), S. 279-284 
    Details
    ISSN: 1432-2072
    Keywords: Chlorpromazine ; 7-Hydroxychlorpromazine ; Chlorpromazine Sulphoxide ; Clinical Response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eight male adult schizophrenic patients undergoing chronic treatment with chlorpromazine were investigated. Clinical assessments were made weekly by a psychiatrist who was unaware of the biochemical findings. Blood samples were drawn 3 h after the first daily dose and the plasma concentrations of chlorpromazine and 11 of its metabolites were assessed by a direct scan technique employing quantitative thin layer chromatography. Patients that responded well to treatment had high plasma levels of chlorpromazine and 7-hydroxychlorpromazine; whereas non-responders had high plasma levels of chlorpromazine sulphoxide. These preliminary findings support the hypothesis that chlorpromazine metabolites play an important role in determining clinical response to treatment, which arose from the failure of previous investigators to show a statistically significant relationship between plasma levels of the parent compound and clinical response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422150
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Comparison of near-isogenic lines for anthracnoseAre are genes in common bean,Phaseolus vulgaris L. (1987)
    Springer
    Euphytica 36 (1987), S. 251-256 
    Details
    ISSN: 1573-5060
    Keywords: Phaseolus vulgaris ; bean, near-isogenic line ; Colletotrichum lindemuthianum ; bean anthracnose ; Are gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary This study was undertaken to determine whether the Are gene controlling anthracnose resistance had an adverse effect on maturity and yield because backcross-derived cultivars/lines had numerically lower yield and later maturity than the respective recurrent parent. Three pairs of common bean lines near-isogenic for theAre gene were developed fromAre are F2 plants of the sixth backcross of Seafarer, Fleetwood, and Ex Rico 23. The near-isogenic lines were tested along with the recurrent cultivars and backcross-derived cultivars/lines. The results showed no evidence of any adverse effect of theAre gene on the agronomic characteristics in 11 trails at 5 locations in 3 years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00730671
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Production of penicillin in a fluidized-bed bioreactor using a carrier-supported mycelial growth (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 28 (1986), S. 1838-1844 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A carrier-supported mycelial growth of Penicillium chrysogenum was applied to penicillin fermentation system using celite as a support material. Hyphal growth through the pore matrices of the material showed strong anchorages and provided highly stable biofilm growth. With bioparticles developed in such a manner, both cell growth and penicillin production were observed to increase significantly compared to the conventional dispersed filamentous cultures. Maximum values of specific penicillin production rate were found to be constant regardless of the growth form. A three-phase fluidized-bed fermentor was designed and tested for penicillin production using the bioparticles. Two modes of operation, semicontinuous and repeated fed batch, of the fermentor were tried. It was noted that the overgrowth of free mycelia and the development of fluffy loose bioparticles caused poor mixing and made the fermentor operation quite difficult. Control of the bioparticle size and the extension of production phase were therefore considered important to maintain the reactor productivity at a desired level. From the results of repeated fed-batch operation it was found that the control of bioparticle size could be successfully achieved by phosphate-limiting culture condition. Penicillin production under this condition was also observed to be maintained at a high level (about 80% of the maximum) for at least 1 month.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260281211
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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