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  • 2005-2009
  • 1985-1989  (1)
  • 1970-1974  (1)
  • Clinical Response  (1)
  • Colletotrichum lindemuthianum  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The possible role of metabolites in therapeutic response to chlorpromazine treatment (1973)
    Springer
    Psychopharmacology 32 (1973), S. 279-284 
    Details
    ISSN: 1432-2072
    Keywords: Chlorpromazine ; 7-Hydroxychlorpromazine ; Chlorpromazine Sulphoxide ; Clinical Response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eight male adult schizophrenic patients undergoing chronic treatment with chlorpromazine were investigated. Clinical assessments were made weekly by a psychiatrist who was unaware of the biochemical findings. Blood samples were drawn 3 h after the first daily dose and the plasma concentrations of chlorpromazine and 11 of its metabolites were assessed by a direct scan technique employing quantitative thin layer chromatography. Patients that responded well to treatment had high plasma levels of chlorpromazine and 7-hydroxychlorpromazine; whereas non-responders had high plasma levels of chlorpromazine sulphoxide. These preliminary findings support the hypothesis that chlorpromazine metabolites play an important role in determining clinical response to treatment, which arose from the failure of previous investigators to show a statistically significant relationship between plasma levels of the parent compound and clinical response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422150
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Comparison of near-isogenic lines for anthracnoseAre are genes in common bean,Phaseolus vulgaris L. (1987)
    Springer
    Euphytica 36 (1987), S. 251-256 
    Details
    ISSN: 1573-5060
    Keywords: Phaseolus vulgaris ; bean, near-isogenic line ; Colletotrichum lindemuthianum ; bean anthracnose ; Are gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary This study was undertaken to determine whether the Are gene controlling anthracnose resistance had an adverse effect on maturity and yield because backcross-derived cultivars/lines had numerically lower yield and later maturity than the respective recurrent parent. Three pairs of common bean lines near-isogenic for theAre gene were developed fromAre are F2 plants of the sixth backcross of Seafarer, Fleetwood, and Ex Rico 23. The near-isogenic lines were tested along with the recurrent cultivars and backcross-derived cultivars/lines. The results showed no evidence of any adverse effect of theAre gene on the agronomic characteristics in 11 trails at 5 locations in 3 years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00730671
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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