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  • 11
    Electronic Resource
    Electronic Resource
    Chromosomal aberrations in squamous cell carcinomas of the upper aerodigestive tract: biologic insights and clinical opportunities (2005)
    Oxford, UK : Munksgaard International Publishers
    Journal of oral pathology & medicine 34 (2005), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Oncogenesis results from a progressive accumulation of genetic aberrations consequent to a complex interplay between carcinogenic factors and innate infidelity of DNA surveillance mechanisms. Although the development of genetic aberrations is random, those conferring survival advantages are selected for in a Darwinian manner, thus allowing continuous adaptation to selection pressures. Chromosomal aberrations are a prominent manifestation of genetic damage, which can be closely linked with tumor behavior and outcome as exemplified by curative treatment of chronic myelogenous leukemia resulting from targeting the BCR-ABL translocation. In the case of head and neck squamous cell carcinomas (HNSCC), chromosomal changes are detectable at all stages of tumor development, providing excellent opportunities for genomic prognostication and therapy. Several studies have shown that the overall genomic profile of HNSCC is highly consistent, but individual tumors vary significantly in their complement of genetic alterations, thereby confounding clinical correlation. The application of modern genetic and bioinformatic analytic approaches has facilitated the identification of critical genomic changes in HNSCC, many of which have been linked to clinical outcome. These genetic aberrations represent excellent targets for novel therapeutics, but require validation. The initiation of phase III trials evaluating the therapeutic utility of genetic aberrations suggests a promising future for genome-based treatment of HNSCC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.2005.00343.x
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  • 12
    Electronic Resource
    Electronic Resource
    Respiratory adaptations in the larvae of Monoptems cuchia (Ham.) (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 34 (1989), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1989.tb03343.x
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  • 13
    Electronic Resource
    Electronic Resource
    Oral epithelial cell lipid synthesis in the presence of retinoic acid or nitrosonornicotine (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 15 (1986), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The current study examines the effects of N-nitrosonornicotine (NNN) and all trans-retinoic acid (RA) on the synthesis and composition of lipids of oral epithelial cells grown in culture. Cells were exposed to NNN, RA or methylene chloride (the vehicle for the NNN and RA) and the lipids labelled with [14C]-acetate. Lipids were extracted from the cells, separated by paper chromatography, located by autoradiography, and acetate incorporation determined by liquid scintillation spectrometry. Cholesterol labelling was significantly decreased by the RA between 4 and 48 h when compared to the NNN-treated or control cells. After 48 h the incorporation levels in the presence of the two last compounds decreased. Free fatty acid labelling was also significantly less in cells exposed to RA, while labelling of triglycerides and phospholipids was increased. N-nitrosonornicotine seemed to produce a decreased labelling of cholesterol after 96 h continuous exposure. The results of these studies suggest that retinoid rapidly elevates the cell content of lipid formed from the glycerolipid pathway and membrane mechanisms may be modulated by this effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1986.tb00652.x
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  • 14
    Electronic Resource
    Electronic Resource
    A simplified method for culture of oral epithelial cells (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 14 (1985), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In order to facilitate studies on oral mucosa a simplified method for the culture of oral epithelial cells from adult hamsters was developed. Cheek pouches were excised and epithelial cells isolated by collagenase digestion. These were grown in CM-V medium containing spermine in order to inhibit overgrowth of the epithelial cells by fibroblasts. The epithelial cells were subcultured by routine tissue culture procedures. The cells isolated were examined by light microscopy and scanning and transmission electron microscopy. Morphologically the cells were typical of epithelial cells. Ultrastructural examination showed structures typical of epithelia including filaments, keratohyalin granules and desmosomal junctions. The culture system provides epithelial cells that can be used for a variety of biochemical and morphological studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1985.tb00501.x
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  • 15
    Electronic Resource
    Electronic Resource
    In vivo effects of Sn-1,2-dioctanoylglycerol, TPA and A23187 on hamster cheek pouch epithelium (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 17 (1988), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cheek pouches of male Syrian golden hamsters were topically treated with a single dose of TPA (.5 μg), calcium ionophore A23187 (75 μgs) or Sn-1,2-dioctanoylglycerol (DiC8) (500 μg) dissolved in 0.25 ml acetone. Acetone-treated animals served as controls. After 48 h the mitotic index for the control group was 1.1 ± 0.1 per 1 mm of the basement membrane length. All the test congeners exhibited higher mitotic indices than controls: TPA (4.8 ± 0.4), A23187 (3.9 ± 0.3), DiC8 (2.1 ± 0.2). All groups exhibited an increase in the epithelial thickness manifested by cellular hyperplasia. The treatment of the pouches with the anti-inflammatory agent fluocinolone acetonide inhibited the milogenic and hyperplasiogenic affects on the epithelium induced by the various test chemicals. These studies indicate a possible role of calcium-phospholipid dependent protein kinase (protein kinase C) in the mediation of oral epithelial cell proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1988.tb01327.x
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  • 16
    Electronic Resource
    Electronic Resource
    North-East India: Demography, Culture and Identity Crisis (1987)
    Cambridge : Cambridge University Press
    Modern Asian studies 21 (1987), S. 257-282 
    Details
    ISSN: 0026-749X
    Source: Cambridge Journals Digital Archives
    Topics: Ethnic Sciences , History , Political Science , Economics
    Notes: The management of public affairs in northeast India has been in focus in the regional, national and world press in recent years. Much of the attention has been confined to insurgency, the ‘foreign nationals’ issue, tribal ‘uprisings’, ‘brutalities’ committed by the security forces, ‘involvement’ of foreign agencies in the area, political ‘horse-trading’ and floods. There has been no analysis of the economic, cultural and demographic factors which have acquired different nuances in the wake of the rapid modernization taking place in the region since the 1950s and which have a decisive say on the formulation of policies and the efficacy of institutions of governance in northeast India. This paper proposes to offer some facts and reflections on these aspects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1017/S0026749X00013809
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  • 17
    Electronic Resource
    Electronic Resource
    The geometrization of hydromagnetic fluid flows (1986)
    Springer
    Astrophysics and space science 124 (1986), S. 105-114 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract In this paper certain theorems of theoretical interest have been established with the help of the geometrical properties of Maxwellian surface (which is spanned by the flow and field lines). These theorems shed light on the behaviour of steady incompressible hydromagnetic flows. The complex-lamellar acceleration and simple geodesic motion admitted by such flows have also been studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00649753
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  • 18
    Electronic Resource
    Electronic Resource
    Boussinesq's problem for a debonded boundary (1989)
    Springer
    Zeitschrift für angewandte Mathematik und Physik 40 (1989), S. 1-14 
    Details
    ISSN: 1420-9039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract The present paper examines the problem of the axial loading of a rigid circular punch which is located at the debonded boundary of an elastic medium-rigid boundary interface. The mathematical analysis of the problem focusses primarily on the evaluation of the load-displacement response for the punch boundary of the debonded region. The numerical results presented in the paper illustrate the manner in which the axial stiffness of the punch is influenced by the Poisson's ratio of the elastic medium and the relative dimensions of the debonded region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00945306
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  • 19
    Electronic Resource
    Electronic Resource
    The Reissner-Sagoci problem for a half-space with a surface constraint (1989)
    Springer
    Zeitschrift für angewandte Mathematik und Physik 40 (1989), S. 762-768 
    Details
    ISSN: 1420-9039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract In this paper, the Reissner-Sagoci problem for a half-space with a surface constraint is considered. The problem is reduced to the triple integral equation by use of integral transforms. The triple integral equations are solved for small values of parameters characterizing the geometry of the problem. An expression for the torque required to rotate the disc through a fixed angle is obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00945876
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  • 20
    Electronic Resource
    Electronic Resource
    Modelling to Reduce the Configuration Phase Time of Machine Design (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 44-46 (June 2008), p. 659-668 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The configuration phase for a new machine design is expensive and time consuming forspecial purpose machine manufacturers. This papers presents a modelling approach that can aid suchcompanies reduce the configuration phase time and its respective costs. The approach isdemonstrated with an industrial case study
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/40/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.44-46.659.pdf
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