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  • 1
    Electronic Resource
    Electronic Resource
    Effects of carbamazepine on cerebrospinal fluid somatostatin (1985)
    Springer
    Psychopharmacology 85 (1985), S. 210-213 
    Details
    ISSN: 1432-2072
    Keywords: Carbamazepine ; Somatostatin ; Cerebrospinal fluid ; Affective illness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This paper reports the reduction of the concentration of the neuropeptide somatostatin in the CSF of patients with affective illness during treatment with the anticovulsant carbamazepine. None of the other psychotropic agents used in this study similarly affected CSF somatostatin, although zimelidine appeared to increase CSF somatostatin in a small number of patients. The potential mechanism and significance of the effects of carbamazepine on CSF somatostatin are discussed in relation to the psychotropic, anticonvulsant, and analgesic properties of carbamazepine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428416
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of carbamazepine on noradrenergic mechanisms in affectively ill patients (1985)
    Springer
    Psychopharmacology 87 (1985), S. 59-63 
    Details
    ISSN: 1432-2072
    Keywords: Norepinephrine ; 3-Methoxy-4-hydroxyphenylglycol ; Manic-depressive illness ; Carbamazepine ; Cerebrospinal fluid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Noradrenergic mechanisms have been postulated to account for the anticonvulsant and psychotropic effects of carbamazepine. In order to assess this possibility in man, cerebrospinal fluid (CSF) was obtained from affectively ill patients before and during treatment with carbamazepine (average duration 29 days) at doses averaging 860 mg/day, achieving blood levels of 8.86 μg/ml. Neither plasma nor CSF norepinephrine (NE) nor CSF 3-methoxy-4-hydroxyphenylgycol (MHPG) was significantly altered by carbamazepine. Baseline medication-free values in 21 depressed patients were not predictive of the degree of subsequent clinical antidepressant response. CSF NE decreased in four manic patients treated with carbamazepine. The many effects of carbamazepine on noradrenergic mechanisms in animals are discussed in relationship to these first studies of carbamazepine in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431779
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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