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  • 2005-2009
  • 1985-1989  (2)
  • R 113  (1)
  • insulitis  (1)
  • 1
    ISSN: 1432-0428
    Keywords: Cyclosporin ; NOD mice ; Type 1 diabetes ; insulitis ; autoimmunity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Non-obese diabetic mice aged 30 to 60 days were treated orally with Cyclosporin at doses of 25,15 and 2.5 mg/kg every 2 days until 160 days of age. Diabetes developed in 12 out of 18 oil-treated mice (67%), with partial to complete Langerhans' islet destruction associated with lymphocytic infiltration. The non-obese diabetic mice showed a plasma glucose concentration of 6.62 ± 0.92 mmol/l (mean ± SD) at 50 days of age. The plasma glucose level of oil-treated non-obese diabetic mice gradually increased after 130 days of age and reached 14.0 to 19.0 mmol/l at 160 days of age, while Cyclosporin-treated non-obese diabetic mice showed neither clear increase of plasma glucose levels nor development of insulitis. The cumulative incidence of diabetes in Cyclosporin-treated mice was significantly lower than that in oil-treated mice (p 〈 0.01). Subsequently, Cyclosporin treatment was started after development of glucose intolerance. Twenty-five mg/kg of Cyclosporin was administered every 2 days for 35 days. Cyclosporin appeared to have little therapeutic effect on diabetes in non-obese diabetic mice.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International journal of thermophysics 9 (1988), S. 409-424 
    ISSN: 1572-9567
    Keywords: adhesion ; interfacial tension ; n-pentane ; pendant drop method ; R 113 ; spreading coefficient ; surface tension ; water
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The surface and the interfacial tensions of mutually immiscible liquid systems were experimentally studied. The measured systems are n-pentane-water and R 113-water, which are proposed as heat transfer fluids for a direct-contact heat exchanger to be used for geothermal and waste heat recovery plants. The experimental apparatus was constructed based on the principle of the pendant drop method. Measurements were performed in the temperature range from 20 to 150°C. Based on the correlation of the surface and the interfacial tensions, the temperature dependences of the spreading coefficient, the film pressure, and the work of adhesion in each system were calculated.
    Type of Medium: Electronic Resource
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